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Doxycycline: History, Applications & Research

Doxycycline, sold under the brand names Vibramycin and Doryx, among others, is a broad-spectrum antibiotic of the tetracycline class used in the treatment of infections caused by bacteria and certain parasites. It is used to treat bacterial pneumonia, acne, chlamydia infections, Lyme disease, cholera, typhus, and syphilis, and is sometimes used to…

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Doxycycline topic overview

The analysis highlights History, Applications and Research as prominent areas in the source structure around Doxycycline.

Related topics
317
Source areas
9
Connected nodes
326
Extracted relationships
138
Concept neighborhoods
40
Bridge connections
326

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 130 topics
Medical uses · 60 topics
Research · 50 topics
Pharmacology · 26 topics
Contraindications · 15 topics
Chemistry · 13 topics
History · 11 topics
Adverse effects · 9 topics
Interactions · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J01AA02 (WHO) A01AB22 (WHO)
Bioavailability
~100%
CAS Number
564-25-0
ChEBI
CHEBI:60648

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Adverse effects

Interactions

Pharmacology

Chemistry

History

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Doxycycline connects Entity context

The extracted context around Doxycycline shows recurring relationship patterns in the source. For example, Doxycycline → After, American Cyanamid, As, Both, Charlie Stephens, Drug Administration, FDA, Instead, International Rectifier, International Rectifier's, Lloyd Conover, Pfizer, Rachelle Laboratories, Scientists, Shortly, US, US Food, World War II Another extracted example is Doxycycline → Cytokines, ECM, IL-1, IL-10, IL-6, MMP7, MMPs, NF-κB, Some, TNF-α. Use these groups to spot repeated connection types before inspecting the individual relationships.

Doxycycline

Top relations

related to history · 18
Doxycycline → After, American Cyanamid, As, Both, Charlie Stephens, Drug Administration, FDA, Instead, International Rectifier, International Rectifier's, Lloyd Conover, Pfizer, Rachelle Laboratories, Scientists, Shortly, US, US Food, World War II
related to Anti-inflammatory agent · 10
Doxycycline → Cytokines, ECM, IL-1, IL-10, IL-6, MMP7, MMPs, NF-κB, Some, TNF-α
related to Pregnancy and lactation · 9
Doxycycline → CDC, Disease Control, FDA, However, Other, Prevention, The, The FDA, The US Centers
has effect · 6
Doxycycline → Adverse, An, Clostridioides, One, Oral, The
related to Absorption and excretion · 6
Doxycycline → About, By, CSF, It, The, Very
related to Antimalarial · 6
Doxycycline → As, By, For, Plasmodium, These, This
related to Dosing · 6
Doxycycline → Although, As, Compared, For, Lyme, Therefore
related to Medical uses · 6
Doxycycline → Beyond, Gram-negative, Gram-positive, Like, Lyme, The
related to Spectrum of susceptibility · 6
Doxycycline → Chlamydia, Mycoplasma, Representative, Streptococcus, The, Ureaplasma
related to Chemistry · 5
Doxycycline → C-6, Expired, Fanconi, In, Nevertheless

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

used tetracycline treatment disease infections bacteria acne anti-inflammatory rosacea also malaria antibiotic drug including effects use treat may lyme conditions

Doxycycline relationships Subject–Predicate–Object triples

TTTA extracted 138 structured relationships around Doxycycline. Examples in this analysis include Doxycycline → 3D model (JSmol) → Interactive image and Doxycycline → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Doxycycline3D model (JSmol)Interactive image1.00infobox
DoxycyclineAHFS/Drugs.comMonograph1.00infobox
DoxycyclineATC codeJ01AA02 (WHO) A01AB22 (WHO)1.00infobox
DoxycyclineBioavailability~100%1.00infobox
DoxycyclineCAS Number564-25-01.00infobox
DoxycyclineChEBICHEBI:606481.00infobox
DoxycyclineChEMBLChEMBL14331.00infobox
DoxycyclineChemSpider104821061.00infobox
DoxycyclineCompTox Dashboard (EPA)DTXSID00376531.00infobox
DoxycyclineDrugBankDB002541.00infobox
DoxycyclineECHA InfoCard100.008.4291.00infobox
DoxycyclineElimination half-life10–22 hours1.00infobox
DoxycyclineExcretionMainly feces, 40% urine1.00infobox
DoxycyclineFormulaC22H24N2O81.00infobox
DoxycyclineKEGGD078761.00infobox
DoxycyclineLegal statusAU: S4 (Prescription only)1.00infobox
DoxycyclineLegal statusUK: POM (Prescription only)1.00infobox
DoxycyclineLegal statusUS: ℞-only1.00infobox
DoxycyclineLicense dataUS DailyMed: Doxycycline1.00infobox
DoxycyclineMedlinePlusa6820631.00infobox
DoxycyclineMetabolismNegligible1.00infobox
DoxycyclineMolar mass444.440 g·mol−11.00infobox
DoxycyclinePregnancy categoryAU: D1.00infobox
DoxycyclinePronunciation/ˌdɒksɪˈsaɪkliːn/ DOKS-ih-SYE-kleen1.00infobox
DoxycyclineProtein binding80–90%1.00infobox
DoxycyclinePubChem CIDDoxycycline1.00infobox
DoxycyclineRoutes of administrationBy mouth, intravenous1.00infobox
DoxycyclineTrade namesVibramycin, Doryx, others1.00infobox
DoxycyclineUNII334895S8621.00infobox
Doxycyclineis ainhibitor of matrix metalloproteases0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Doxycycline bring nearby vocabulary together. In this analysis, examples include Used, Treatment and Disease. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Doxycycline
    • Used
    • Treatment
    • Disease
    • Infections
    • Tetracycline
    • Conditions
    • May
    • Treat
    • Including
    • Also
    • Anti-inflammatory
    • Research
  • doxycycline
    • Used
    • Treatment
    • Disease
    • Infections
    • Tetracycline
    • Conditions
    • May
    • Treat
    • Including
    • Also
    • Anti-inflammatory
    • Research
  • tetracycline class
    • Antibiotics
    • Tetracycline
    • Absorption
    • Bacteria
    • Protein
    • Pregnancy
    • Research
    • Used
    • Use
    • Infections
    • Caused
    • Production
  • bacteria
    • Protein
    • Infections
    • Including
    • Class
    • Drug
    • Caused
    • Bacterial
    • However
    • Effects
    • Tetracycline
    • Used
    • Antibiotics
  • acne
    • Rosacea
    • Anti-inflammatory
    • Inflammation
    • Treat
    • Conditions
    • Effects
    • Used
    • Properties
    • Disease
    • Lyme
    • Antibiotic
    • Including
  • chlamydia infections
    • Used
    • Treat
    • Bacterial
    • Lyme
    • Chlamydia
    • Infections
    • Prevent
    • Prophylaxis
    • Disease
    • Including
    • Drug
    • Antibiotics
  • sexually transmitted infections
    • Used
    • Treat
    • Bacterial
    • Lyme
    • Chlamydia
    • Prevent
    • Prophylaxis
    • Disease
    • Including
    • Drug
    • Antibiotics
    • Due
  • respiratory tract infections
    • Used
    • Treat
    • Bacterial
    • Lyme
    • Chlamydia
    • Prevent
    • Prophylaxis
    • Disease
    • Including
    • Drug
    • Antibiotics
    • Due

Connections between topic areas Semantic bridges

For Doxycycline, one of the stronger structural bridges in this analysis connects Doxycycline with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Doxycycline — Overview · splits 196 ⟂ 131
Doxycycline — Medical uses · splits 266 ⟂ 61
Doxycycline — Research · splits 276 ⟂ 51
Doxycycline — Pharmacology · splits 300 ⟂ 27
Doxycycline — Contraindications · splits 311 ⟂ 16
Doxycycline — Chemistry · splits 313 ⟂ 14
Doxycycline — History · splits 315 ⟂ 12
Doxycycline — Adverse effects · splits 317 ⟂ 10
Doxycycline — Interactions · splits 323 ⟂ 4

Map overview Semantic statistics

Doxycycline

Nodes327
Edges326
Triples138
Avg. degree1.99
Density0.006116
Components1

Source & methodology

TTTA analyzes the structure around Doxycycline to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Doxycycline · EN edition · Analysis: TopicsToTalkAbout

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