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LRP5: Clinical significance, Transcription & Interactions

Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis pseudoglioma syndrome…

Language: English [EN]
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LRP5 topic overview

The analysis highlights Clinical significance, Transcription and Interactions as prominent areas in the source structure around LRP5.

Related topics
44
Source areas
6
Connected nodes
50
Extracted relationships
168
Concept neighborhoods
13
Bridge connections
50

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 19 topics
Overview · 8 topics
Transcription · 7 topics
Interactions · 5 topics
Structure · 4 topics
Function · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
LRP5, BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2, LDL receptor related protein 5, PCLD4, LRP-7
Band
11q13.2 · 19|19 A
Bgee
right lobe of liver · mucosa of transverse colon · ascending aorta · apex of heart · minor salivary glands
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 19 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Transcription

Interactions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How LRP5 connects Entity context

The extracted context around LRP5 shows recurring relationship patterns in the source. For example, LRP5 → adipose tissue development, anatomical structure regression, anterior/posterior pattern specification, apoptotic process involved in blood vessel morphogenesis, beta-catenin destruction complex disassembly, bone development, bone marrow development, bone morphogenesis, bone remodeling, branching involved in mammary gland duct morphogenesis, canonical Wnt signaling pathway, cell migration involved in gastrulation, cell-cell signaling involved in mammary gland development, cholesterol homeostasis, cholesterol metabolic process, coreceptor activity involved in canonical Wnt signaling pathway, coreceptor activity involved in Wnt signaling pathway, embryonic digit morphogenesis, endocytosis, endoplasmic reticulum Another extracted example is LRP5 → apex of heart, ascending aorta, Descending thoracic aorta, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, genital tubercle, lip, male urethra, minor salivary glands, mucosa of transverse colon, muscle layer of urethra, olfactory zone of nasal mucosa, popliteal artery, right coronary artery, right lobe of liver, spermatid, tibial arteries, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

LRP5

Top relations

Gene ontology · 64
LRP5 → adipose tissue development, anatomical structure regression, anterior/posterior pattern specification, apoptotic process involved in blood vessel morphogenesis, beta-catenin destruction complex disassembly, bone development, bone marrow development, bone morphogenesis, bone remodeling, branching involved in mammary gland duct morphogenesis, canonical Wnt signaling pathway, cell migration involved in gastrulation, cell-cell signaling involved in mammary gland development, cholesterol homeostasis, cholesterol metabolic process, coreceptor activity involved in canonical Wnt signaling pathway, coreceptor activity involved in Wnt signaling pathway, embryonic digit morphogenesis, endocytosis, endoplasmic reticulum
Bgee · 20
LRP5 → apex of heart, ascending aorta, Descending thoracic aorta, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, genital tubercle, lip, male urethra, minor salivary glands, mucosa of transverse colon, muscle layer of urethra, olfactory zone of nasal mucosa, popliteal artery, right coronary artery, right lobe of liver, spermatid, tibial arteries, yolk sac
RNA expression pattern · 20
LRP5 → apex of heart, ascending aorta, Descending thoracic aorta, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, genital tubercle, lip, male urethra, minor salivary glands, mucosa of transverse colon, muscle layer of urethra, olfactory zone of nasal mucosa, popliteal artery, right coronary artery, right lobe of liver, spermatid, tibial arteries, yolk sac
related to Clinical significance · 13
LRP5 → An, Another, Bone, Many, Mice, Mutations, Shortly, The, The Wnt, There, TPH1, Tph1-inhibitor, Wnt
related to Interactions · 10
LRP5 → AXIN1, Canonical WNT, Frizzled, GSK3B, GSK3beta, LRP5/LRP6, LRP6, Reduction, Ser-9, Wnt
related to Transcription · 7
LRP5 → In, KLF15, On, RUNX2, SP1, The LRP5, TPH1
related to Structure · 5
LRP5 → Each, EGF, In, LRP6, Most
related to Function · 4
LRP5 → Frizzled, LRP6, This, Wnt
Band · 2
LRP5 → 11q13.2, 19|19 A
Chr. · 2
LRP5 → Chromosome 11 (human), Chromosome 19 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bone protein wnt gene mass bp lrp6 human expression pathway chr band mutations receptor canonical chromosome 11 mrna mice also

LRP5 relationships Subject–Predicate–Object triples

TTTA extracted 168 structured relationships around LRP5. Examples in this analysis include LRP5 → Aliases → LRP5, BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2, LDL receptor related protein 5, PCLD4, LRP-7 and LRP5 → Band → 11q13.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
LRP5AliasesLRP5, BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2, LDL receptor related protein 5, PCLD4, LRP-71.00infobox
LRP5Band11q13.21.00infobox
LRP5Band19|19 A1.00infobox
LRP5Bgeeright lobe of liver1.00infobox
LRP5Bgeemucosa of transverse colon1.00infobox
LRP5Bgeeascending aorta1.00infobox
LRP5Bgeeapex of heart1.00infobox
LRP5Bgeeminor salivary glands1.00infobox
LRP5BgeeDescending thoracic aorta1.00infobox
LRP5Bgeepopliteal artery1.00infobox
LRP5Bgeetibial arteries1.00infobox
LRP5Bgeeolfactory zone of nasal mucosa1.00infobox
LRP5Bgeeright coronary artery1.00infobox
LRP5Bgeeepithelium of urethra1.00infobox
LRP5Bgeemale urethra1.00infobox
LRP5Bgeeyolk sac1.00infobox
LRP5Bgeeepithelium of male urethra1.00infobox
LRP5Bgeefemale urethra1.00infobox
LRP5Bgeeepithelium of female urethra1.00infobox
LRP5Bgeemuscle layer of urethra1.00infobox
LRP5Bgeelip1.00infobox
LRP5Bgeespermatid1.00infobox
LRP5Bgeegenital tubercle1.00infobox
LRP5BioGPSMore reference expression data1.00infobox
LRP5Chr.Chromosome 11 (human)1.00infobox
LRP5Chr.Chromosome 19 (mouse)1.00infobox
LRP5DatabasesNCBI: entry; OMA: entry1.00infobox
LRP5End68,449,275 bp1.00infobox
LRP5End3,736,564 bp1.00infobox
LRP5EnsemblENSG000001623371.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around LRP5 bring nearby vocabulary together. In this analysis, examples include Bone, Wnt and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • LRP5
    • Bone
    • Wnt
    • Protein
    • Lrp6
    • Expression
    • Canonical
    • Mutations
    • Pathway
    • Binding
    • Plasma
    • Receptor
    • Also
  • lrp5
    • Bone
    • Wnt
    • Protein
    • Lrp6
    • Expression
    • Canonical
    • Mutations
    • Pathway
    • Binding
    • Plasma
    • Receptor
    • Also
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Human
    • Lipoprotein
    • Structure
    • End
    • Mouse
    • Band
    • Binding
    • Receptor
  • canonical wnt pathway
    • Lrp6
    • Pathway
    • Wnt
    • Frizzled
    • Canonical
    • Involved
    • Signaling
    • Receptor
    • Lrp5
    • Human
    • Mrna
    • Binding
  • lipoprotein
    • Structure
    • Gene
    • End
    • Humans
    • Involved
    • Location
    • Membrane
    • Mouse
    • Band
    • Binding
    • Chromosome
    • Extracellular
  • wnt proteins
    • Pathway
    • Canonical
    • Lrp6
    • Frizzled
    • Signaling
    • Lrp5
    • Involved
    • Binding
    • Receptor
    • Protein
    • Human
    • Mrna
  • lrp6
    • Wnt
    • Pathway
    • Extracellular
    • Receptor
    • Structure
    • Protein
    • End
    • Location
    • Membrane
    • Mouse
    • Band
    • Binding
  • protein
    • Membrane
    • Extracellular
    • Receptor
    • Mrna
    • Expression
    • Structure
    • Wnt
    • Location
    • Binding
    • Chromosome
    • Signaling
    • Bp

Connections between topic areas Semantic bridges

For LRP5, one of the stronger structural bridges in this analysis connects LRP5 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
LRP5Clinical significance · splits 31 ⟂ 20
LRP5Overview · splits 42 ⟂ 9
LRP5Transcription · splits 43 ⟂ 8
LRP5Interactions · splits 45 ⟂ 6
LRP5Structure · splits 46 ⟂ 5

Map overview Semantic statistics

LRP5

Nodes51
Edges50
Triples168
Avg. degree1.96
Density0.039216
Components1

Source & methodology

TTTA analyzes the structure around LRP5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Transcription & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — LRP5 · EN edition · Analysis: TopicsToTalkAbout

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