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LRP5

Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis pseudoglioma syndrome…

Clinical significance, Transcription & Interactions

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Aliases
LRP5, BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2, LDL receptor related protein 5, PCLD4, LRP-7
Band
11q13.2 · 19|19 A
Bgee
right lobe of liver · mucosa of transverse colon · ascending aorta · apex of heart · minor salivary glands
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 19 (mouse)
Databases
NCBI: entry; OMA: entry

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Clinical significance

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LRP5

Nodes51
Edges50
Triples168
Avg. degree1.96
Density0.039216
Components1

How this topic connects Entity context

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LRP5

Top relations

Gene ontology · 64
LRP5 → adipose tissue development, anatomical structure regression, anterior/posterior pattern specification, apoptotic process involved in blood vessel morphogenesis, beta-catenin destruction complex disassembly, bone development, bone marrow development, bone morphogenesis, bone remodeling, branching involved in mammary gland duct morphogenesis, canonical Wnt signaling pathway, cell migration involved in gastrulation, cell-cell signaling involved in mammary gland development, cholesterol homeostasis, cholesterol metabolic process, coreceptor activity involved in canonical Wnt signaling pathway, coreceptor activity involved in Wnt signaling pathway, embryonic digit morphogenesis, endocytosis, endoplasmic reticulum
Bgee · 20
LRP5 → apex of heart, ascending aorta, Descending thoracic aorta, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, genital tubercle, lip, male urethra, minor salivary glands, mucosa of transverse colon, muscle layer of urethra, olfactory zone of nasal mucosa, popliteal artery, right coronary artery, right lobe of liver, spermatid, tibial arteries, yolk sac
RNA expression pattern · 20
LRP5 → apex of heart, ascending aorta, Descending thoracic aorta, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, genital tubercle, lip, male urethra, minor salivary glands, mucosa of transverse colon, muscle layer of urethra, olfactory zone of nasal mucosa, popliteal artery, right coronary artery, right lobe of liver, spermatid, tibial arteries, yolk sac
related to Clinical significance · 13
LRP5 → An, Another, Bone, Many, Mice, Mutations, Shortly, The, The Wnt, There, TPH1, Tph1-inhibitor, Wnt
related to Interactions · 10
LRP5 → AXIN1, Canonical WNT, Frizzled, GSK3B, GSK3beta, LRP5/LRP6, LRP6, Reduction, Ser-9, Wnt
related to Transcription · 7
LRP5 → In, KLF15, On, RUNX2, SP1, The LRP5, TPH1
related to Structure · 5
LRP5 → Each, EGF, In, LRP6, Most
related to Function · 4
LRP5 → Frizzled, LRP6, This, Wnt
Band · 2
LRP5 → 11q13.2, 19|19 A
Chr. · 2
LRP5 → Chromosome 11 (human), Chromosome 19 (mouse)

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Important terminology

bone protein wnt gene mass bp lrp6 human expression pathway chr band mutations receptor canonical chromosome 11 mrna mice also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
LRP5AliasesLRP5, BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2, LDL receptor related protein 5, PCLD4, LRP-71.00infobox
LRP5Band11q13.21.00infobox
LRP5Band19|19 A1.00infobox
LRP5Bgeeright lobe of liver1.00infobox
LRP5Bgeemucosa of transverse colon1.00infobox
LRP5Bgeeascending aorta1.00infobox
LRP5Bgeeapex of heart1.00infobox
LRP5Bgeeminor salivary glands1.00infobox
LRP5BgeeDescending thoracic aorta1.00infobox
LRP5Bgeepopliteal artery1.00infobox
LRP5Bgeetibial arteries1.00infobox
LRP5Bgeeolfactory zone of nasal mucosa1.00infobox
LRP5Bgeeright coronary artery1.00infobox
LRP5Bgeeepithelium of urethra1.00infobox
LRP5Bgeemale urethra1.00infobox
LRP5Bgeeyolk sac1.00infobox
LRP5Bgeeepithelium of male urethra1.00infobox
LRP5Bgeefemale urethra1.00infobox
LRP5Bgeeepithelium of female urethra1.00infobox
LRP5Bgeemuscle layer of urethra1.00infobox
LRP5Bgeelip1.00infobox
LRP5Bgeespermatid1.00infobox
LRP5Bgeegenital tubercle1.00infobox
LRP5BioGPSMore reference expression data1.00infobox
LRP5Chr.Chromosome 11 (human)1.00infobox
LRP5Chr.Chromosome 19 (mouse)1.00infobox
LRP5DatabasesNCBI: entry; OMA: entry1.00infobox
LRP5End68,449,275 bp1.00infobox
LRP5End3,736,564 bp1.00infobox
LRP5EnsemblENSG000001623371.00infobox

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