LRP6

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Explore the main themes, entities and connections around LRP6. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Structure

Lipoprotein Receptor Amino-acid YWTD Β-propeller

9 related topics

Interactions

GSK3B Phosphorylation Catenin Dickkopf DKK1

6 related topics

Clinical significance

Anabolic Parathyroid hormone Mechanotransduction

3 related topics

Overview

Protein Gene LRP5 Frizzled Canonical Wnt pathway

5 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: LRP6, ADCAD2, STHAG7, LDL receptor related protein 6
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S2K, 3S8V, 3S8Z, 3S94, 3SOB, 3SOQ, 3SOV, 4A0P, 4DG6, 4NM5, 4NM7
Band: 12p13.2 · 6 G1|6 65.37 cM
Bgee: Achilles tendon · corpus callosum · ventricular zone · gonad · liver
BioGPS: More reference expression data
Chr.: Chromosome 12 (human) · Chromosome 6 (mouse)

Topics to explore

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Overview

Protein
Gene
LRP5
Frizzled
Canonical Wnt pathway Wnt signaling pathway

Structure

Interactions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes28

Edges27

Triples185

Avg. degree1.93

Density0.071429

Components1

How this topic connects Entity context

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LRP6

Top relations

Gene ontology · 88

LRP6 → anterior/posterior pattern specification, apolipoprotein binding, axis elongation involved in somitogenesis, beta-catenin destruction complex disassembly, bone morphogenesis, bone remodeling, branching involved in mammary gland duct morphogenesis, canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in neural crest cell differentiation, canonical Wnt signaling pathway involved in regulation of cell proliferation, caveola, cell surface, cell-cell adhesion, cellular response to cholesterol, cerebellum morphogenesis, cerebral cortex development, chemical synaptic transmission, convergent extension, coreceptor activity involved in canonical Wnt signaling pathway, coreceptor activity involved in Wnt signaling pathway

Bgee · 20

LRP6 → Achilles tendon, aortic valve, ascending aorta, choroid plexus of fourth ventricle, corpus callosum, cumulus cell, epithelium of colon, extraocular muscle, ganglionic eminence, gonad, Gonadal ridge, lactiferous gland, liver, placenta, secondary oocyte, stroma of bone marrow, stromal cell of endometrium, sural nerve, ventricular zone, zygote

RNA expression pattern · 20

related to Interactions · 13

LRP6 → Canonical WNT, Dickkopf, Dkk, DKK1, Frizzled, GSK3B, GSK3beta, LRP5, LRP5/LRP6, R-spondins, Reduction, Ser-9, Wnt

related to Clinical significance · 10

LRP6 → Alzheimer's, Common, LDL, Loss-of-function, LRP5, On, PTH, Sclerostin, Similarly, Wnt

related to Structure · 7

LRP6 → Each, EGF, In, LDLR, LRP5, Most, YWTD

related to Function · 3

LRP6 → Frizzled, LRP5, Wnt

Band · 2

LRP6 → 12p13.2, 6 G1|6 65.37 cM

Chr. · 2

LRP6 → Chromosome 12 (human), Chromosome 6 (mouse)

End · 2

LRP6 → 12,267,044 bp, 134,543,928 bp

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

lrp5 wnt protein bp chr human band gene canonical frizzled chromosome 12 receptor extracellular lipoprotein low-density involved pathway location end

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
LRP6	Aliases	LRP6, ADCAD2, STHAG7, LDL receptor related protein 6	1.00	infobox
LRP6	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S2K, 3S8V, 3S8Z, 3S94, 3SOB, 3SOQ, 3SOV, 4A0P, 4DG6, 4NM5, 4NM7	1.00	infobox
LRP6	Band	12p13.2	1.00	infobox
LRP6	Band	6 G1\|6 65.37 cM	1.00	infobox
LRP6	Bgee	Achilles tendon	1.00	infobox
LRP6	Bgee	corpus callosum	1.00	infobox
LRP6	Bgee	ventricular zone	1.00	infobox
LRP6	Bgee	gonad	1.00	infobox
LRP6	Bgee	liver	1.00	infobox
LRP6	Bgee	stromal cell of endometrium	1.00	infobox
LRP6	Bgee	ganglionic eminence	1.00	infobox
LRP6	Bgee	epithelium of colon	1.00	infobox
LRP6	Bgee	placenta	1.00	infobox
LRP6	Bgee	sural nerve	1.00	infobox
LRP6	Bgee	ascending aorta	1.00	infobox
LRP6	Bgee	aortic valve	1.00	infobox
LRP6	Bgee	stroma of bone marrow	1.00	infobox
LRP6	Bgee	cumulus cell	1.00	infobox
LRP6	Bgee	choroid plexus of fourth ventricle	1.00	infobox
LRP6	Bgee	lactiferous gland	1.00	infobox
LRP6	Bgee	secondary oocyte	1.00	infobox
LRP6	Bgee	extraocular muscle	1.00	infobox
LRP6	Bgee	zygote	1.00	infobox
LRP6	Bgee	Gonadal ridge	1.00	infobox
LRP6	BioGPS	More reference expression data	1.00	infobox
LRP6	Chr.	Chromosome 12 (human)	1.00	infobox
LRP6	Chr.	Chromosome 6 (mouse)	1.00	infobox
LRP6	Databases	NCBI: entry; OMA: entry	1.00	infobox
LRP6	End	12,267,044 bp	1.00	infobox
LRP6	End	134,543,928 bp	1.00	infobox

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