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Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.
The analysis highlights Structure, Interactions and Clinical significance as prominent areas in the source structure around LRP6.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around LRP6 shows recurring relationship patterns in the source. For example, LRP6 → anterior/posterior pattern specification, apolipoprotein binding, axis elongation involved in somitogenesis, beta-catenin destruction complex disassembly, bone morphogenesis, bone remodeling, branching involved in mammary gland duct morphogenesis, canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in neural crest cell differentiation, canonical Wnt signaling pathway involved in regulation of cell proliferation, caveola, cell surface, cell-cell adhesion, cellular response to cholesterol, cerebellum morphogenesis, cerebral cortex development, chemical synaptic transmission, convergent extension, coreceptor activity involved in canonical Wnt signaling pathway, coreceptor activity involved in Wnt signaling pathway Another extracted example is LRP6 → Achilles tendon, aortic valve, ascending aorta, choroid plexus of fourth ventricle, corpus callosum, cumulus cell, epithelium of colon, extraocular muscle, ganglionic eminence, gonad, Gonadal ridge, lactiferous gland, liver, placenta, secondary oocyte, stroma of bone marrow, stromal cell of endometrium, sural nerve, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
lrp5 wnt protein bp chr human band gene canonical frizzled chromosome 12 receptor extracellular lipoprotein low-density involved pathway location end
TTTA extracted 185 structured relationships around LRP6. Examples in this analysis include LRP6 → Aliases → LRP6, ADCAD2, STHAG7, LDL receptor related protein 6 and LRP6 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S2K, 3S8V, 3S8Z, 3S94, 3SOB, 3SOQ, 3SOV, 4A0P, 4DG6, 4NM5, 4NM7. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| LRP6 | Aliases | LRP6, ADCAD2, STHAG7, LDL receptor related protein 6 | 1.00 | infobox |
| LRP6 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S2K, 3S8V, 3S8Z, 3S94, 3SOB, 3SOQ, 3SOV, 4A0P, 4DG6, 4NM5, 4NM7 | 1.00 | infobox |
| LRP6 | Band | 12p13.2 | 1.00 | infobox |
| LRP6 | Band | 6 G1|6 65.37 cM | 1.00 | infobox |
| LRP6 | Bgee | Achilles tendon | 1.00 | infobox |
| LRP6 | Bgee | corpus callosum | 1.00 | infobox |
| LRP6 | Bgee | ventricular zone | 1.00 | infobox |
| LRP6 | Bgee | gonad | 1.00 | infobox |
| LRP6 | Bgee | liver | 1.00 | infobox |
| LRP6 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| LRP6 | Bgee | ganglionic eminence | 1.00 | infobox |
| LRP6 | Bgee | epithelium of colon | 1.00 | infobox |
| LRP6 | Bgee | placenta | 1.00 | infobox |
| LRP6 | Bgee | sural nerve | 1.00 | infobox |
| LRP6 | Bgee | ascending aorta | 1.00 | infobox |
| LRP6 | Bgee | aortic valve | 1.00 | infobox |
| LRP6 | Bgee | stroma of bone marrow | 1.00 | infobox |
| LRP6 | Bgee | cumulus cell | 1.00 | infobox |
| LRP6 | Bgee | choroid plexus of fourth ventricle | 1.00 | infobox |
| LRP6 | Bgee | lactiferous gland | 1.00 | infobox |
| LRP6 | Bgee | secondary oocyte | 1.00 | infobox |
| LRP6 | Bgee | extraocular muscle | 1.00 | infobox |
| LRP6 | Bgee | zygote | 1.00 | infobox |
| LRP6 | Bgee | Gonadal ridge | 1.00 | infobox |
| LRP6 | BioGPS | More reference expression data | 1.00 | infobox |
| LRP6 | Chr. | Chromosome 12 (human) | 1.00 | infobox |
| LRP6 | Chr. | Chromosome 6 (mouse) | 1.00 | infobox |
| LRP6 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| LRP6 | End | 12,267,044 bp | 1.00 | infobox |
| LRP6 | End | 134,543,928 bp | 1.00 | infobox |
The concept neighborhoods around LRP6 bring nearby vocabulary together. In this analysis, examples include Lrp5, Wnt and Canonical. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For LRP6, one of the stronger structural bridges in this analysis connects LRP6 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around LRP6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — LRP6 · EN edition · Analysis: TopicsToTalkAbout