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TPH1

Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase which in humans is encoded by the TPH1 gene.

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1.14.16.4
Aliases
TPH1, TPRH, TRPH, tryptophan hydroxylase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MLW, 3HF6, 3HF8, 3HFB, 5J6D
Band
11p15.1 · 7 B3|7 30.43 cM
Bgee
buccal mucosa cell · rectum · ascending aorta · Descending thoracic aorta · mucosa of sigmoid colon
BioGPS
More reference expression data

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Map overview Semantic statistics

TPH1

Nodes33
Edges32
Triples88
Avg. degree1.94
Density0.060606
Components1

How this topic connects Entity context

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TPH1

Top relations

Bgee · 18
TPH1 → ascending aorta, buccal mucosa cell, Descending thoracic aorta, duodenum, embryo, extraocular muscle, jejunal mucosa, jejunum, lactiferous gland, left colon, mucosa of sigmoid colon, muscle of thigh, pineal gland, pyloric antrum, pylorus, rectum, testicle, tibial arteries
Gene ontology · 18
TPH1 → aromatic amino acid family metabolic process, bone remodeling, circadian rhythm, cytoplasm, cytosol, indolalkylamine biosynthetic process, iron ion binding, mammary gland alveolus development, metal ion binding, monooxygenase activity, negative regulation of ossification, neuron projection, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen, positive regulation of fat cell differentiation, response to immobilization stress, serotonin biosynthetic process, tryptophan 5-monooxygenase activity
RNA expression pattern · 18
TPH1 → ascending aorta, buccal mucosa cell, Descending thoracic aorta, duodenum, embryo, extraocular muscle, jejunal mucosa, jejunum, lactiferous gland, left colon, mucosa of sigmoid colon, muscle of thigh, pineal gland, pyloric antrum, pylorus, rectum, testicle, tibial arteries
related to Clinical significance · 9
TPH1 → A218C, Alzheimer's, DNA, For, Introns, Nevertheless, One, The, Tryptophan
Band · 2
TPH1 → 11p15.1, 7 B3|7 30.43 cM
Chr. · 2
TPH1 → Chromosome 11 (human), Chromosome 7 (mouse)
End · 2
TPH1 → 18,046,269 bp, 46,321,961 bp
1.14.16.4 · 1
TPH1 → ↗
Aliases · 1
TPH1 → TPH1, TPRH, TRPH, tryptophan hydroxylase 1
Available structures · 1
TPH1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MLW, 3HF6, 3HF8, 3HFB, 5J6D

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Important terminology

gene tryptophan human bp serotonin chr band chromosome 11 mouse hydroxylase tph brain location found intron 5-hydroxytryptophan tph2 one amino

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TPH11.14.16.41.00infobox
TPH1AliasesTPH1, TPRH, TRPH, tryptophan hydroxylase 11.00infobox
TPH1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MLW, 3HF6, 3HF8, 3HFB, 5J6D1.00infobox
TPH1Band11p15.11.00infobox
TPH1Band7 B3|7 30.43 cM1.00infobox
TPH1Bgeebuccal mucosa cell1.00infobox
TPH1Bgeerectum1.00infobox
TPH1Bgeeascending aorta1.00infobox
TPH1BgeeDescending thoracic aorta1.00infobox
TPH1Bgeemucosa of sigmoid colon1.00infobox
TPH1Bgeetesticle1.00infobox
TPH1Bgeepylorus1.00infobox
TPH1Bgeetibial arteries1.00infobox
TPH1Bgeejejunal mucosa1.00infobox
TPH1Bgeeduodenum1.00infobox
TPH1Bgeepineal gland1.00infobox
TPH1Bgeelactiferous gland1.00infobox
TPH1Bgeepyloric antrum1.00infobox
TPH1Bgeeembryo1.00infobox
TPH1Bgeejejunum1.00infobox
TPH1Bgeemuscle of thigh1.00infobox
TPH1Bgeeleft colon1.00infobox
TPH1Bgeeextraocular muscle1.00infobox
TPH1BioGPSMore reference expression data1.00infobox
TPH1Chr.Chromosome 11 (human)1.00infobox
TPH1Chr.Chromosome 7 (mouse)1.00infobox
TPH1DatabasesNCBI: entry; OMA: entry1.00infobox
TPH1End18,046,269 bp1.00infobox
TPH1End46,321,961 bp1.00infobox
TPH1EnsemblENSG000001291671.00infobox

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