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Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase which in humans is encoded by the TPH1 gene.
The analysis highlights Standards, Clinical significance and Function as prominent areas in the source structure around TPH1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around TPH1 shows recurring relationship patterns in the source. For example, TPH1 → ascending aorta, buccal mucosa cell, Descending thoracic aorta, duodenum, embryo, extraocular muscle, jejunal mucosa, jejunum, lactiferous gland, left colon, mucosa of sigmoid colon, muscle of thigh, pineal gland, pyloric antrum, pylorus, rectum, testicle, tibial arteries Another extracted example is TPH1 → aromatic amino acid family metabolic process, bone remodeling, circadian rhythm, cytoplasm, cytosol, indolalkylamine biosynthetic process, iron ion binding, mammary gland alveolus development, metal ion binding, monooxygenase activity, negative regulation of ossification, neuron projection, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen, positive regulation of fat cell differentiation, response to immobilization stress, serotonin biosynthetic process, tryptophan 5-monooxygenase activity. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene tryptophan human bp serotonin chr band chromosome 11 mouse hydroxylase tph brain location found intron 5-hydroxytryptophan tph2 one amino
TTTA extracted 88 structured relationships around TPH1. Examples in this analysis include TPH1 → 1.14.16.4 → ↗ and TPH1 → Aliases → TPH1, TPRH, TRPH, tryptophan hydroxylase 1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TPH1 | 1.14.16.4 | ↗ | 1.00 | infobox |
| TPH1 | Aliases | TPH1, TPRH, TRPH, tryptophan hydroxylase 1 | 1.00 | infobox |
| TPH1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MLW, 3HF6, 3HF8, 3HFB, 5J6D | 1.00 | infobox |
| TPH1 | Band | 11p15.1 | 1.00 | infobox |
| TPH1 | Band | 7 B3|7 30.43 cM | 1.00 | infobox |
| TPH1 | Bgee | buccal mucosa cell | 1.00 | infobox |
| TPH1 | Bgee | rectum | 1.00 | infobox |
| TPH1 | Bgee | ascending aorta | 1.00 | infobox |
| TPH1 | Bgee | Descending thoracic aorta | 1.00 | infobox |
| TPH1 | Bgee | mucosa of sigmoid colon | 1.00 | infobox |
| TPH1 | Bgee | testicle | 1.00 | infobox |
| TPH1 | Bgee | pylorus | 1.00 | infobox |
| TPH1 | Bgee | tibial arteries | 1.00 | infobox |
| TPH1 | Bgee | jejunal mucosa | 1.00 | infobox |
| TPH1 | Bgee | duodenum | 1.00 | infobox |
| TPH1 | Bgee | pineal gland | 1.00 | infobox |
| TPH1 | Bgee | lactiferous gland | 1.00 | infobox |
| TPH1 | Bgee | pyloric antrum | 1.00 | infobox |
| TPH1 | Bgee | embryo | 1.00 | infobox |
| TPH1 | Bgee | jejunum | 1.00 | infobox |
| TPH1 | Bgee | muscle of thigh | 1.00 | infobox |
| TPH1 | Bgee | left colon | 1.00 | infobox |
| TPH1 | Bgee | extraocular muscle | 1.00 | infobox |
| TPH1 | BioGPS | More reference expression data | 1.00 | infobox |
| TPH1 | Chr. | Chromosome 11 (human) | 1.00 | infobox |
| TPH1 | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| TPH1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TPH1 | End | 18,046,269 bp | 1.00 | infobox |
| TPH1 | End | 46,321,961 bp | 1.00 | infobox |
| TPH1 | Ensembl | ENSG00000129167 | 1.00 | infobox |
The concept neighborhoods around TPH1 bring nearby vocabulary together. In this analysis, examples include Human, Tryptophan and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TPH1, one of the stronger structural bridges in this analysis connects TPH1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TPH1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TPH1 · EN edition · Analysis: TopicsToTalkAbout