Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Interleukin 1-alpha: Applications & Products

Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. In general, interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1α inhibitors are being developed to interrupt those processes and treat diseases.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

Interleukin 1-alpha topic overview

The analysis highlights Applications and Products as prominent areas in the source structure around Interleukin 1-alpha.

Related topics
99
Source areas
8
Connected nodes
107
Extracted relationships
97
Concept neighborhoods
31
Bridge connections
107

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Biological activity · 31 topics
Production and cellular sources · 29 topics
Interactions · 16 topics
Overview · 9 topics
Synthesis and structure · 9 topics
Applications · 2 topics
Regulatory molecules · 2 topics
Discovery · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha, IL-1α
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ILA, 2KKI, 2L5X
Band
2q14.1 · 2 F1|2 62.9 cM
Bgee
periodontal fiber · oral cavity · buccal mucosa cell · mucosa of urinary bladder · testicle
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Synthesis and structure

Production and cellular sources

Interactions

Regulatory molecules

Biological activity

Applications

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Interleukin 1-alpha connects Entity context

The extracted context around Interleukin 1-alpha shows recurring relationship patterns in the source. For example, Interleukin 1-alpha → apoptotic process, cell population proliferation, cellular response to heat, connective tissue replacement involved in inflammatory response wound healing, copper ion binding, cytokine activity, cytokine-mediated signaling pathway, cytoplasm, cytosol, ectopic germ cell programmed cell death, extracellular region, extracellular space, extrinsic apoptotic signaling pathway in absence of ligand, fever generation, immune response, inflammatory response, interleukin-1 receptor binding, interleukin-1-mediated signaling pathway, negative regulation of cell population proliferation, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Another extracted example is Interleukin 1-alpha → buccal mucosa cell, cornea, corneal stroma, embryo, epidermis, esophagus, gingival epithelium, gums, islet of Langerhans, left testis, lip, liver, mucosa of urinary bladder, oral cavity, periodontal fiber, placenta, right testis, skin of back, spermatocyte, testicle. Use these groups to spot repeated connection types before inspecting the individual relationships.

Interleukin 1-alpha

Top relations

Gene ontology · 33
Interleukin 1-alpha → apoptotic process, cell population proliferation, cellular response to heat, connective tissue replacement involved in inflammatory response wound healing, copper ion binding, cytokine activity, cytokine-mediated signaling pathway, cytoplasm, cytosol, ectopic germ cell programmed cell death, extracellular region, extracellular space, extrinsic apoptotic signaling pathway in absence of ligand, fever generation, immune response, inflammatory response, interleukin-1 receptor binding, interleukin-1-mediated signaling pathway, negative regulation of cell population proliferation, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Bgee · 20
Interleukin 1-alpha → buccal mucosa cell, cornea, corneal stroma, embryo, epidermis, esophagus, gingival epithelium, gums, islet of Langerhans, left testis, lip, liver, mucosa of urinary bladder, oral cavity, periodontal fiber, placenta, right testis, skin of back, spermatocyte, testicle
RNA expression pattern · 20
Interleukin 1-alpha → buccal mucosa cell, cornea, corneal stroma, embryo, epidermis, esophagus, gingival epithelium, gums, islet of Langerhans, left testis, lip, liver, mucosa of urinary bladder, oral cavity, periodontal fiber, placenta, right testis, skin of back, spermatocyte, testicle
Band · 2
Interleukin 1-alpha → 2 F1|2 62.9 cM, 2q14.1
Chr. · 2
Interleukin 1-alpha → Chromosome 2 (human), Chromosome 2 (mouse)
End · 2
Interleukin 1-alpha → 112,784,493 bp, 129,151,892 bp
Aliases · 1
Interleukin 1-alpha → IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha, IL-1α
Available structures · 1
Interleukin 1-alpha → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ILA, 2KKI, 2L5X
BioGPS · 1
Interleukin 1-alpha → More reference expression data
Databases · 1
Interleukin 1-alpha → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

il-1α cells production human activity interleukin bp chr band gene keratinocytes interleukin-1 fever precursor chromosome cytokine synthesis endothelial immune skin

Interleukin 1-alpha relationships Subject–Predicate–Object triples

TTTA extracted 97 structured relationships around Interleukin 1-alpha. Examples in this analysis include Interleukin 1-alpha → Aliases → IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha, IL-1α and Interleukin 1-alpha → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ILA, 2KKI, 2L5X. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Interleukin 1-alphaAliasesIL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha, IL-1α1.00infobox
Interleukin 1-alphaAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ILA, 2KKI, 2L5X1.00infobox
Interleukin 1-alphaBand2q14.11.00infobox
Interleukin 1-alphaBand2 F1|2 62.9 cM1.00infobox
Interleukin 1-alphaBgeeperiodontal fiber1.00infobox
Interleukin 1-alphaBgeeoral cavity1.00infobox
Interleukin 1-alphaBgeebuccal mucosa cell1.00infobox
Interleukin 1-alphaBgeemucosa of urinary bladder1.00infobox
Interleukin 1-alphaBgeetesticle1.00infobox
Interleukin 1-alphaBgeegums1.00infobox
Interleukin 1-alphaBgeeright testis1.00infobox
Interleukin 1-alphaBgeeleft testis1.00infobox
Interleukin 1-alphaBgeegingival epithelium1.00infobox
Interleukin 1-alphaBgeeislet of Langerhans1.00infobox
Interleukin 1-alphaBgeeesophagus1.00infobox
Interleukin 1-alphaBgeeskin of back1.00infobox
Interleukin 1-alphaBgeeembryo1.00infobox
Interleukin 1-alphaBgeeepidermis1.00infobox
Interleukin 1-alphaBgeecornea1.00infobox
Interleukin 1-alphaBgeespermatocyte1.00infobox
Interleukin 1-alphaBgeeliver1.00infobox
Interleukin 1-alphaBgeecorneal stroma1.00infobox
Interleukin 1-alphaBgeelip1.00infobox
Interleukin 1-alphaBgeeplacenta1.00infobox
Interleukin 1-alphaBioGPSMore reference expression data1.00infobox
Interleukin 1-alphaChr.Chromosome 2 (human)1.00infobox
Interleukin 1-alphaChr.Chromosome 2 (mouse)1.00infobox
Interleukin 1-alphaDatabasesNCBI: entry; OMA: entry1.00infobox
Interleukin 1-alphaEnd112,784,493 bp1.00infobox
Interleukin 1-alphaEnd129,151,892 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Interleukin 1-alpha bring nearby vocabulary together. In this analysis, examples include Gene, Interleukin-1 and Biological. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Interleukin 1-alpha
    • Gene
    • Interleukin-1
    • Biological
    • Il1a
    • Location
    • Production
    • Chromosome
    • Fever
    • Bp
    • Chr
    • Human
    • Activity
  • interleukin 1-alpha
    • Gene
    • Interleukin-1
    • Biological
    • Il1a
    • Location
    • Production
    • Chromosome
    • Fever
    • Bp
    • Chr
    • Human
    • Activity
  • cytokine
    • Gene
    • Interleukin-1
    • Known
    • Interleukin
    • Biological
    • Epidermis
    • Il-1
    • Il1a
    • Location
    • Mrna
    • Proliferation
    • Receptor
  • interleukin 1 family
    • Gene
    • Interleukin-1
    • Biological
    • Il1a
    • Location
    • Production
    • Chromosome
    • Fever
    • Bp
    • Chr
    • Human
    • Activity
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Interleukin
    • Human
    • Biological
    • Il-1
    • Il1a
    • Band
    • Interleukin-1
    • Activity
  • interleukin-1 receptor
    • Interleukin
    • Receptor
    • Cytokine
    • Gene
    • Mrna
    • Proliferation
    • Biological
    • Epidermis
    • Factor
    • Il1a
    • Immune
    • Location
  • interleukin-1 beta
    • Interleukin
    • Receptor
    • Cytokine
    • Gene
    • Biological
    • Epidermis
    • Il1a
    • Location
    • Mrna
    • Proliferation
    • Band
    • Chromosome
  • skin
    • Epidermis
    • Mrna
    • Endothelial
    • Immune
    • Keratinocytes
    • Precursor
    • Activity
    • Production
    • Biological
    • Location
    • Macrophages
    • Neutrophils

Connections between topic areas Semantic bridges

For Interleukin 1-alpha, one of the stronger structural bridges in this analysis connects Interleukin 1-alpha with Biological activity. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Interleukin 1-alpha — Biological activity · splits 76 ⟂ 32
Interleukin 1-alpha — Production and cellular sources · splits 78 ⟂ 30
Interleukin 1-alpha — Interactions · splits 91 ⟂ 17
Interleukin 1-alpha — Overview · splits 98 ⟂ 10
Interleukin 1-alpha — Synthesis and structure · splits 98 ⟂ 10
Interleukin 1-alpha — Regulatory molecules · splits 105 ⟂ 3
Interleukin 1-alpha — Applications · splits 105 ⟂ 3

Map overview Semantic statistics

Interleukin 1-alpha

Nodes108
Edges107
Triples97
Avg. degree1.98
Density0.018519
Components1

Source & methodology

TTTA analyzes the structure around Interleukin 1-alpha to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Interleukin 1-alpha · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.