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Folate

Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Folate is required for the body to make DNA and RNA and metabolize amino acids necessary for cell division and maturation of blood cells. As the human body cannot make folate, it is required in the diet, making it an essential nutrient. It occurs naturally in many foods. The…

History, Health effects & Absorption, metabolism and excretion

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
B03BB01 (WHO) V04CX02 (WHO) B03AE02 (WHO) B03AE01 (WHO) B03BB51 (WHO)
Bioavailability
50–100%
CAS Number
59-30-3 · as salt: 6484-89-5
ChEBI
CHEBI:27470

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Overview

Definition

Function

Health effects

Absorption, metabolism and excretion

Drug interference

Dietary recommendations

Deficiency

Sources

Food fortification

History

Advanced semantic analysis

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Map overview Semantic statistics

Folate

Nodes172
Edges171
Triples311
Avg. degree1.99
Density0.011628
Components1

How this topic connects Entity context

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Folate

Top relations

related to Dietary recommendations · 37
Folate → Adequate Intakes, AI, AIs, Authority, Average Requirement, Because, Committee, DFE, Dietary Reference Intakes, Dietary Reference Values, DRIs, EAR, EARs, EFSA, Estimated Average Requirements, Food, For, Institute, Medical Aspects, Medicine
related to history · 25
Folate → American Cyanamid Company, Bc, Bob Stokstad, Director, Esmond, Herschel, Historic, In, It, Latin, Lederle Lab, Lederle Laboratories, Lucy Wills, Mitchell, New York, Pearl River, Research Dr, Roger, Sidney Farber, Snell
related to Safety · 17
Folate → B12, B12-deficient, Evidence, Excessive, Health, In, Long-term, Nutrition, One, Reviews, The, The EFSA, The Japan National Institute, This, UL, ULs, United States
related to Bioactivation · 16
Folate → All, B3, B6, C6, CH2-THF, Each, Folic, Hence, Mechanistically, MTHFD2, NADP, NADPH, PLP, SHMT, THF, This
related to Food labeling · 16
Folate → As, Compliance, Daily Value, Daily Values, DV, European Union, For, Instead, January, May, Reference Daily Intake, Reference Intakes, RI, RIs, US, Voluntary
related to Absorption, metabolism and excretion · 13
Folate → In, It, PCFT, Production, RFC, SLC19A1, SLC46A1, Subsequently, The, THF, This, Tolerable Upper Intake Level, When
related to Birth defects · 13
Folate → CDC, Deficiency, Disease Control, Many, NTDs, One, Prenatal, Prevention, Services Task Force, Some, The Center, The United States Preventive, There
related to External links · 13
Folate → Biochemical, Biochemistry, Current, Enzyme Nomenclature, International Union, Miscellaneous Reaction Schemes, Molecular Biology's Recommendations, Organic Nomenclature, Pterins, Queen Mary College, Riboflavins, Symbols, Terminology
related to Neurological disorders · 13
Folate → Alzheimer's, American, ASD, Asian, B12, Cerebral, Conversion, Elevated, European, However, Maternal, Supplementing, Treatment
related to Australia and New Zealand · 12
Folate → Australia, Bakers, Food Safety Minister Kate, Food Standards Australia New, Green Party, In, July, New Zealand, The, The Association, Wilkinson, Zealand

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Important terminology

acid folic fortification deficiency food dietary μg risk vitamin supplementation may blood intake foods also used b12 cancer countries defects

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Folate3D model (JSmol)Interactive image1.00infobox
FolateAHFS/Drugs.comMonograph1.00infobox
FolateATC codeB03BB01 (WHO) V04CX02 (WHO) B03AE02 (WHO) B03AE01 (WHO) B03BB51 (WHO)1.00infobox
FolateBioavailability50–100%1.00infobox
FolateCAS Number59-30-31.00infobox
FolateCAS Numberas salt: 6484-89-51.00infobox
FolateChEBICHEBI:274701.00infobox
FolateChEMBLChEMBL16221.00infobox
FolateChemSpider58151.00infobox
FolateChemSpideras salt: 215121.00infobox
FolateCompTox Dashboard (EPA)DTXSID00225191.00infobox
FolateDensity1.6±0.1 g/cm31.00infobox
FolateDrugBankDB001581.00infobox
FolateDrugBankas salt: DBSALT0019181.00infobox
FolateECHA InfoCard100.000.3811.00infobox
FolateExcretionUrine1.00infobox
FolateFormulaC19H19N7O61.00infobox
FolateIUPHAR/BPS45631.00infobox
FolateKEGGD000701.00infobox
FolateKEGGas salt: D079851.00infobox
FolateLegal statusAU: S4 (Prescription only) / S21.00infobox
FolateLegal statusUS: ℞-only / OTC1.00infobox
FolateLicense dataUS DailyMed: Folic acid1.00infobox
FolateMedlinePlusa6825911.00infobox
FolateMelting point250 °C (482 °F) (decomposition)1.00infobox
FolateMetabolismLiver1.00infobox
FolateMolar mass441.404 g·mol−11.00infobox
FolateOther namesWills factor, FA, N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid, pteroyl-L-glutamic acid (PteGlu), folacin, vitamin B9; formerly, vitamin…1.00infobox
FolatePDB ligandFOL (PDBe, RCSB PDB)1.00infobox
FolatePregnancy categoryAU: A1.00infobox

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