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Fibronectin

Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).

Structure, Function & Role in cancer

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Key facts & relationships

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Aliases
FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF
Available structures
Available structuresPDBOrtholog search: H0Y7Z1%20or%20B7ZLE5 PDBe H0Y7Z1,B7ZLE5 RCSB List of PDB id codes1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6,…
Band
2q35 · 1 C3|1 36.05 cM
Bgee
synovial joint · right coronary artery · decidua · Descending thoracic aorta · synovial membrane
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)

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Overview

Structure

Function

Matrix assembly

Role in cancer

Role in wound healing

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Fibronectin

Nodes135
Edges134
Triples186
Avg. degree1.99
Density0.014815
Components1

How this topic connects Entity context

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Fibronectin

Top relations

Gene ontology · 42
Fibronectin → acute-phase response, angiogenesis, apical plasma membrane, basement membrane, blood microparticle, calcium-independent cell-matrix adhesion, cell adhesion, cell-matrix adhesion, cell-substrate junction assembly, collagen binding, endodermal cell differentiation, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, extracellular fluid, extracellular matrix, extracellular matrix disassembly, extracellular matrix organization, extracellular region, fibrinogen complex, heparin binding
Bgee · 20
Fibronectin → ankle, ascending aorta, atrium, calvaria, decidua, Descending thoracic aorta, endothelial cell of lymphatic vessel, left coronary artery, left lung lobe, right coronary artery, stroma of bone marrow, stromal cell of endometrium, synovial joint, synovial membrane, tail of embryo, tendon of biceps brachii, tibia, tibiofemoral joint, tunica media of zone of aorta, umbilical cord
RNA expression pattern · 20
Fibronectin → ankle, ascending aorta, atrium, calvaria, decidua, Descending thoracic aorta, endothelial cell of lymphatic vessel, left coronary artery, left lung lobe, right coronary artery, stroma of bone marrow, stromal cell of endometrium, synovial joint, synovial membrane, tail of embryo, tendon of biceps brachii, tibia, tibiofemoral joint, tunica media of zone of aorta, umbilical cord
related to Structure · 15
Fibronectin → All, Beta-sandwich, C-terminal, Each, EIIIA, EIIIB, II, III, III14, It, One, The, The V-region, Three, V-region
related to External links · 13
Fibronectin → Extracellular Adhesion MoleculeThe Fibronectin, Human Fibronectin, Medicine Medical Subject Headings, MeSH, Mouse Fibronectin, National Library, Overview, P02751, P11276, PDB, PDBe-KB, ProteinFibronectin, UniProt
related to Role in wound healing · 11
Fibronectin → An, Based, Collagen, During, Factor XIII, Fibroblast, Fibroblasts, III, Patients, Plasma, The
related to Function · 9
Fibronectin → Along, As, Cellular, Fibroblasts, Fragmentation, Fragmenting, It, These, V-region
related to Interactions · 8
Fibronectin → Besides, BMP-1, FBP-A, FBP-B, For, N-terminal, NSP-4, TNF-α
related to Matrix assembly · 8
Fibronectin → As, Cells, Cellular, Fibronectin's, Short, The, These, This
related to Role in cancer · 4
Fibronectin → In, Several, The, These

Important terminology Word statistics

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Important terminology

matrix protein fibroblasts insoluble wound cell extracellular cells healing soluble plasma cellular human fibrin gene modules type iii collagen adhesion

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FibronectinAliasesFN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF1.00infobox
FibronectinAvailable structuresAvailable structuresPDBOrtholog search: H0Y7Z1%20or%20B7ZLE5 PDBe H0Y7Z1,B7ZLE5 RCSB List of PDB id codes1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6,…1.00infobox
FibronectinBand2q351.00infobox
FibronectinBand1 C3|1 36.05 cM1.00infobox
FibronectinBgeesynovial joint1.00infobox
FibronectinBgeeright coronary artery1.00infobox
FibronectinBgeedecidua1.00infobox
FibronectinBgeeDescending thoracic aorta1.00infobox
FibronectinBgeesynovial membrane1.00infobox
FibronectinBgeeascending aorta1.00infobox
FibronectinBgeetibia1.00infobox
FibronectinBgeetendon of biceps brachii1.00infobox
FibronectinBgeestromal cell of endometrium1.00infobox
FibronectinBgeeleft coronary artery1.00infobox
FibronectinBgeecalvaria1.00infobox
FibronectinBgeestroma of bone marrow1.00infobox
FibronectinBgeetunica media of zone of aorta1.00infobox
FibronectinBgeeumbilical cord1.00infobox
FibronectinBgeeleft lung lobe1.00infobox
FibronectinBgeeankle1.00infobox
FibronectinBgeetail of embryo1.00infobox
FibronectinBgeetibiofemoral joint1.00infobox
FibronectinBgeeendothelial cell of lymphatic vessel1.00infobox
FibronectinBgeeatrium1.00infobox
FibronectinBioGPSMore reference expression data1.00infobox
FibronectinChr.Chromosome 2 (human)1.00infobox
FibronectinChr.Chromosome 1 (mouse)1.00infobox
FibronectinDatabasesNCBI: entry; OMA: entry1.00infobox
FibronectinEnd215,436,073 bp1.00infobox
FibronectinEnd71,692,359 bp1.00infobox

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