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Factor V

Coagulation factor V (Factor V), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by F5 gene. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. Factor V deficiency leads to predisposition for hemorrhage, while some mutations (most…

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Aliases
F5, FVL, PCCF, RPRGL1, THPH2, coagulation factor V
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S9C, 1CZS, 1CZV, 3P6Z, 3P70
Band
1q24.2 · 1 H2.2|1 71.46 cM
Bgee
right lobe of liver · Epithelium of choroid plexus · pancreatic ductal cell · placenta · optic nerve
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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Factor V

Nodes58
Edges57
Triples133
Avg. degree1.97
Density0.034483
Components1

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Factor V

Top relations

Gene ontology · 24
Factor V → blood circulation, blood coagulation, COPII vesicle coating, COPII-coated ER to Golgi transport vesicle, copper ion binding, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular region, extracellular space, extracellular vesicle, Golgi apparatus, Golgi membrane, hemostasis, membrane, metal ion binding, plasma membrane, platelet alpha granule, platelet alpha granule lumen
related to history · 19
Factor V → However, II, III, IV, Mary, Morawitz, Most, Norway, Norwegian, Owren, Paul Morawitz, Paul Owren, Second World War, She, The, The Lancet, They, Until, Using Mary's
Bgee · 17
Factor V → blood, choroid plexus of fourth ventricle, ciliary body, Epithelium of choroid plexus, gallbladder, granulocyte, iris, lacrimal gland, left lobe of liver, monocyte, olfactory zone of nasal mucosa, optic nerve, pancreatic ductal cell, parotid gland, placenta, right lobe of liver, tibiofemoral joint
RNA expression pattern · 17
Factor V → blood, choroid plexus of fourth ventricle, ciliary body, Epithelium of choroid plexus, gallbladder, granulocyte, iris, lacrimal gland, left lobe of liver, monocyte, olfactory zone of nasal mucosa, optic nerve, pancreatic ductal cell, parotid gland, placenta, right lobe of liver, tibiofemoral joint
related to Role in disease · 11
Factor V → Amsterdam, Deficiency, FV, It, Karen, Owren, Texas, There, This, Various, Zimowski
related to External links · 7
Factor V → Coagulation, P12259, PDB, PDBe-KB, ProteinOverview, The Coagulation Factor, UniProt
related to Physiology · 5
Factor V → Factor, FVa, FXa, On, The
related to Structure · 5
Factor V → A1-A2-B-A3-C1-C2, A1-A3, A3, Factor, The
related to Genetics · 3
Factor V → It, The, VIII
Band · 2
Factor V → 1 H2.2|1 71.46 cM, 1q24.2

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Important terminology

factor protein coagulation gene bp thrombin chr human band chromosome prothrombin activated f5 form owren leiden cofactor mutations thrombosis plasma

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Factor VAliasesF5, FVL, PCCF, RPRGL1, THPH2, coagulation factor V1.00infobox
Factor VAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S9C, 1CZS, 1CZV, 3P6Z, 3P701.00infobox
Factor VBand1q24.21.00infobox
Factor VBand1 H2.2|1 71.46 cM1.00infobox
Factor VBgeeright lobe of liver1.00infobox
Factor VBgeeEpithelium of choroid plexus1.00infobox
Factor VBgeepancreatic ductal cell1.00infobox
Factor VBgeeplacenta1.00infobox
Factor VBgeeoptic nerve1.00infobox
Factor VBgeemonocyte1.00infobox
Factor VBgeeolfactory zone of nasal mucosa1.00infobox
Factor VBgeeblood1.00infobox
Factor VBgeegallbladder1.00infobox
Factor VBgeegranulocyte1.00infobox
Factor VBgeechoroid plexus of fourth ventricle1.00infobox
Factor VBgeeleft lobe of liver1.00infobox
Factor VBgeeciliary body1.00infobox
Factor VBgeelacrimal gland1.00infobox
Factor VBgeeiris1.00infobox
Factor VBgeetibiofemoral joint1.00infobox
Factor VBgeeparotid gland1.00infobox
Factor VBioGPSMore reference expression data1.00infobox
Factor VChr.Chromosome 1 (human)1.00infobox
Factor VChr.Chromosome 1 (mouse)1.00infobox
Factor VDatabasesNCBI: entry; OMA: entry1.00infobox
Factor VEnd169,586,588 bp1.00infobox
Factor VEnd164,047,846 bp1.00infobox
Factor VEnsemblENSG000001987341.00infobox
Factor VEntrez21531.00infobox
Factor VExternal IDsOMIM: 612309; MGI: 88382; GeneCards: F51.00infobox

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