Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Tissue transglutaminase

Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC 2.3.2.13) of the protein-glutamine γ-glutamyltransferases family (or simply transglutaminase family). Like other transglutaminases, it crosslinks proteins between an ε-amino group of a lysine residue and a γ-carboxamide group of glutamine residue, creating an…

Clinical significance, Function & Structure

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around Tissue transglutaminase. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.2.13
3.5.1.44
Aliases
TGM2, G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h), hTG2, tTG
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PYG, 1KV3, 2Q3Z, 3LY6, 3S3J, 3S3P, 3S3S
Band
20q11.23 · 2 H1|2 78.72 cM
Bgee
beta cell · right coronary artery · left coronary artery · canal of the cervix · popliteal artery

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Structure

Mechanism

Regulation

Function

Clinical significance

Interactions

Erp57

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Tissue transglutaminase

Nodes101
Edges100
Triples101
Avg. degree1.98
Density0.019802
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Tissue transglutaminase

Top relations

Gene ontology · 33
Tissue transglutaminase → acyltransferase activity, apoptotic cell clearance, blood vessel remodeling, branching involved in salivary gland morphogenesis, collagen-containing extracellular matrix, cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, extracellular matrix, focal adhesion, GTP binding, intrinsic component of plasma membrane, isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine, metal ion binding, mitochondrion, negative regulation of endoplasmic reticulum calcium ion concentration, peptide cross-linking, phospholipase C-activating G protein-coupled receptor signaling pathway, plasma membrane
Bgee · 20
Tissue transglutaminase → ascending aorta, beta cell, canal of the cervix, carotid body, ciliary body, conjunctival fornix, decidua, efferent ductule, external carotid artery, left coronary artery, mesenteric lymph nodes, Paneth cell, popliteal artery, right auricle of heart, right coronary artery, right lung lobe, right uterine tube, tibial arteries, tunica media of zone of aorta, upper lobe of left lung
RNA expression pattern · 20
Tissue transglutaminase → ascending aorta, beta cell, canal of the cervix, carotid body, ciliary body, conjunctival fornix, decidua, efferent ductule, external carotid artery, left coronary artery, mesenteric lymph nodes, Paneth cell, popliteal artery, right auricle of heart, right coronary artery, right lung lobe, right uterine tube, tibial arteries, tunica media of zone of aorta, upper lobe of left lung
Band · 2
Tissue transglutaminase → 2 H1|2 78.72 cM, 20q11.23
Chr. · 2
Tissue transglutaminase → Chromosome 2 (mouse), Chromosome 20 (human)
End · 2
Tissue transglutaminase → 157,988,356 bp, 38,166,578 bp
2.3.2.13 · 1
Tissue transglutaminase → ↗
3.5.1.44 · 1
Tissue transglutaminase → ↗
Aliases · 1
Tissue transglutaminase → TGM2, G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h), hTG2, tTG
Available structures · 1
Tissue transglutaminase → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PYG, 1KV3, 2Q3Z, 3LY6, 3S3J, 3S3P, 3S3S

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ttg activity tg2 extracellular protein also enzyme disulfide disease proteins transglutaminase including calcium cell human gtp bond crosslinking diseases binding

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Tissue transglutaminase2.3.2.131.00infobox
Tissue transglutaminase3.5.1.441.00infobox
Tissue transglutaminaseAliasesTGM2, G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h), hTG2, tTG1.00infobox
Tissue transglutaminaseAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PYG, 1KV3, 2Q3Z, 3LY6, 3S3J, 3S3P, 3S3S1.00infobox
Tissue transglutaminaseBand20q11.231.00infobox
Tissue transglutaminaseBand2 H1|2 78.72 cM1.00infobox
Tissue transglutaminaseBgeebeta cell1.00infobox
Tissue transglutaminaseBgeeright coronary artery1.00infobox
Tissue transglutaminaseBgeeleft coronary artery1.00infobox
Tissue transglutaminaseBgeecanal of the cervix1.00infobox
Tissue transglutaminaseBgeepopliteal artery1.00infobox
Tissue transglutaminaseBgeetibial arteries1.00infobox
Tissue transglutaminaseBgeeright auricle of heart1.00infobox
Tissue transglutaminaseBgeeright uterine tube1.00infobox
Tissue transglutaminaseBgeeupper lobe of left lung1.00infobox
Tissue transglutaminaseBgeedecidua1.00infobox
Tissue transglutaminaseBgeeconjunctival fornix1.00infobox
Tissue transglutaminaseBgeePaneth cell1.00infobox
Tissue transglutaminaseBgeetunica media of zone of aorta1.00infobox
Tissue transglutaminaseBgeeascending aorta1.00infobox
Tissue transglutaminaseBgeeright lung lobe1.00infobox
Tissue transglutaminaseBgeeciliary body1.00infobox
Tissue transglutaminaseBgeemesenteric lymph nodes1.00infobox
Tissue transglutaminaseBgeeefferent ductule1.00infobox
Tissue transglutaminaseBgeecarotid body1.00infobox
Tissue transglutaminaseBgeeexternal carotid artery1.00infobox
Tissue transglutaminaseBioGPSMore reference expression data1.00infobox
Tissue transglutaminaseChr.Chromosome 20 (human)1.00infobox
Tissue transglutaminaseChr.Chromosome 2 (mouse)1.00infobox
Tissue transglutaminaseDatabasesNCBI: entry; OMA: entry1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.