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PER2

PER2 is a protein in mammals encoded by the PER2 gene. PER2 is noted for its major role in circadian rhythms.

Function, Discovery & Clinical significance

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Function

17 related topics

Discovery

6 related topics

Clinical significance

1 related topics

Overview

2 related topics

Key facts & relationships

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Aliases
PER2, FASPS, FASPS1, period circadian clock 2, period circadian regulator 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3GDI, 4CT0, 4U8H
Band
2q37.3 · 1|1 D
Bgee
oocyte · mucosa of paranasal sinus · secondary oocyte · bronchial epithelial cell · palpebral conjunctiva
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)

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Overview

Discovery

Function

Clinical significance

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Map overview Semantic statistics

PER2

Nodes31
Edges30
Triples157
Avg. degree1.94
Density0.064516
Components1

How this topic connects Entity context

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PER2

Top relations

Gene ontology · 38
PER2 → circadian regulation of gene expression, circadian regulation of translation, circadian rhythm, cytoplasm, entrainment of circadian clock by photoperiod, fatty acid metabolic process, gluconeogenesis, glycogen biosynthetic process, histone H3 deacetylation, lactate biosynthetic process, negative regulation of circadian rhythm, negative regulation of fat cell proliferation, negative regulation of protein ubiquitination, negative regulation of transcription by RNA polymerase II, negative regulation of transcription regulatory region DNA binding, negative regulation of transcription, DNA-templated, nucleolus, nucleus, perinuclear region of cytoplasm, positive regulation of cold-induced thermogenesis
Bgee · 20
PER2 → adrenal gland, bronchial epithelial cell, caput epididymis, granulocyte, lacrimal gland, left lung lobe, lobe of cerebellum, median eminence, mucosa of paranasal sinus, nasal epithelium, oocyte, palpebral conjunctiva, primary motor cortex, rectum, respiratory epithelium, secondary oocyte, skin of thigh, suprachiasmatic nucleus, tail of epididymis, urethra
RNA expression pattern · 20
PER2 → adrenal gland, bronchial epithelial cell, caput epididymis, granulocyte, lacrimal gland, left lung lobe, lobe of cerebellum, median eminence, mucosa of paranasal sinus, nasal epithelium, oocyte, palpebral conjunctiva, primary motor cortex, rectum, respiratory epithelium, secondary oocyte, skin of thigh, suprachiasmatic nucleus, tail of epididymis, urethra
related to External links · 14
PER2 → Human Period, Medicine, Medicine Medical Subject Headings, MeSH, Mouse Period, National Library, O15055, O54943, Overview, PDB, PDBe-KB, This, UniProt, United States National Library
related to Function · 8
PER2 → Circadian, Genes, GRE, GREs, Human PER2, Lowered PER2, Mice, Period
related to Discovery · 7
PER2 → Drosophila, Drosophilla, It, Later, Mammalian Per2, PER1, The
related to Gene · 7
PER2 → An, Northern, PER1, Predicted, SCN, The PER2, ZT
related to Main interactions · 7
PER2 → CLOCK/BMAL1, In, Molecular, PAS, PER, The, This
related to Familial advanced sleep phase · 6
PER2 → CK1d, Familial, FASP, S662G, The, The S662G
related to Interactions with CK1e · 4
PER2 → CK1e, FASPS, In Syrian, Mutations

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Important terminology

circadian gene human protein clock bp mouse period expression chr band chromosome also ck1e levels mice mutation nucleus sleep expressed

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PER2AliasesPER2, FASPS, FASPS1, period circadian clock 2, period circadian regulator 21.00infobox
PER2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3GDI, 4CT0, 4U8H1.00infobox
PER2Band2q37.31.00infobox
PER2Band1|1 D1.00infobox
PER2Bgeeoocyte1.00infobox
PER2Bgeemucosa of paranasal sinus1.00infobox
PER2Bgeesecondary oocyte1.00infobox
PER2Bgeebronchial epithelial cell1.00infobox
PER2Bgeepalpebral conjunctiva1.00infobox
PER2Bgeenasal epithelium1.00infobox
PER2Bgeetail of epididymis1.00infobox
PER2Bgeeurethra1.00infobox
PER2Bgeecaput epididymis1.00infobox
PER2Bgeeskin of thigh1.00infobox
PER2Bgeeadrenal gland1.00infobox
PER2Bgeeleft lung lobe1.00infobox
PER2Bgeesuprachiasmatic nucleus1.00infobox
PER2Bgeegranulocyte1.00infobox
PER2Bgeerectum1.00infobox
PER2Bgeelacrimal gland1.00infobox
PER2Bgeemedian eminence1.00infobox
PER2Bgeeprimary motor cortex1.00infobox
PER2Bgeelobe of cerebellum1.00infobox
PER2Bgeerespiratory epithelium1.00infobox
PER2BioGPSMore reference expression data1.00infobox
PER2Chr.Chromosome 2 (human)1.00infobox
PER2Chr.Chromosome 1 (mouse)1.00infobox
PER2DatabasesNCBI: entry; OMA: entry1.00infobox
PER2End238,290,102 bp1.00infobox
PER2End91,387,046 bp1.00infobox

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