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Duffy antigen system

Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is encoded by the ACKR1 gene.

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Genetics and genomics

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Molecular biology

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Population genetics

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Clinical significance

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Aliases
ACKR1, atypical chemokine receptor 1 (Duffy blood group), CCBP1, CD234, Dfy, FY, GPD, GpFy, WBCQ1, DARC, DARC/ACKR1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NUU, 4NUV
Band
1q23.2 · 1 H3|1 80.33 cM
Bgee
vena cava · left uterine tube · gastric mucosa · subcutaneous adipose tissue · pericardium
BioGPS
n/a
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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Overview

History

Genetics and genomics

Molecular biology

Population genetics

Clinical significance

Clinical diagnostic

Transfusion data

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Map overview Semantic statistics

Duffy antigen system

Nodes157
Edges156
Triples85
Avg. degree1.99
Density0.012739
Components1

How this topic connects Entity context

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Duffy antigen system

Top relations

Bgee · 20
Duffy antigen system → bone marrow, canal of the cervix, cerebellar cortex, coronary artery, ectocervix, gastric mucosa, hippocampus proper, hypothalamus, layer of retina, left uterine tube, neural layer of retina, olfactory bulb, olfactory zone of nasal mucosa, pericardium, primary visual cortex, striatum of neuraxis, subcutaneous adipose tissue, superior frontal gyrus, tibial nerve, vena cava
RNA expression pattern · 20
Duffy antigen system → bone marrow, canal of the cervix, cerebellar cortex, coronary artery, ectocervix, gastric mucosa, hippocampus proper, hypothalamus, layer of retina, left uterine tube, neural layer of retina, olfactory bulb, olfactory zone of nasal mucosa, pericardium, primary visual cortex, striatum of neuraxis, subcutaneous adipose tissue, superior frontal gyrus, tibial nerve, vena cava
Gene ontology · 19
Duffy antigen system → C-C chemokine binding, chemokine binding, chemokine-mediated signaling pathway, defense response, early endosome, endosome, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, inflammatory response, integral component of membrane, membrane, plasma membrane, protein binding, recycling endosome, regulation of chemokine production, signal transducer activity, signal transduction, signaling receptor activity, transmembrane signaling receptor activity
Band · 2
Duffy antigen system → 1 H3|1 80.33 cM, 1q23.2
Chr. · 2
Duffy antigen system → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
Duffy antigen system → 159,206,500 bp, 173,161,317 bp
Aliases · 1
Duffy antigen system → ACKR1, atypical chemokine receptor 1 (Duffy blood group), CCBP1, CD234, Dfy, FY, GPD, GpFy, WBCQ1, DARC, DARC/ACKR1
Available structures · 1
Duffy antigen system → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NUU, 4NUV
BioGPS · 1
Duffy antigen system → n/a
Databases · 1
Duffy antigen system → NCBI: entry; OMA: entry

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Important terminology

duffy antigen gene fy darc receptor blood protein also vivax allele appears malaria mutation erythrocytes human found cells binding associated

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Duffy antigen systemAliasesACKR1, atypical chemokine receptor 1 (Duffy blood group), CCBP1, CD234, Dfy, FY, GPD, GpFy, WBCQ1, DARC, DARC/ACKR11.00infobox
Duffy antigen systemAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NUU, 4NUV1.00infobox
Duffy antigen systemBand1q23.21.00infobox
Duffy antigen systemBand1 H3|1 80.33 cM1.00infobox
Duffy antigen systemBgeevena cava1.00infobox
Duffy antigen systemBgeeleft uterine tube1.00infobox
Duffy antigen systemBgeegastric mucosa1.00infobox
Duffy antigen systemBgeesubcutaneous adipose tissue1.00infobox
Duffy antigen systemBgeepericardium1.00infobox
Duffy antigen systemBgeetibial nerve1.00infobox
Duffy antigen systemBgeeolfactory zone of nasal mucosa1.00infobox
Duffy antigen systemBgeeectocervix1.00infobox
Duffy antigen systemBgeecoronary artery1.00infobox
Duffy antigen systemBgeecanal of the cervix1.00infobox
Duffy antigen systemBgeecerebellar cortex1.00infobox
Duffy antigen systemBgeelayer of retina1.00infobox
Duffy antigen systemBgeeneural layer of retina1.00infobox
Duffy antigen systemBgeebone marrow1.00infobox
Duffy antigen systemBgeeprimary visual cortex1.00infobox
Duffy antigen systemBgeesuperior frontal gyrus1.00infobox
Duffy antigen systemBgeestriatum of neuraxis1.00infobox
Duffy antigen systemBgeehippocampus proper1.00infobox
Duffy antigen systemBgeeolfactory bulb1.00infobox
Duffy antigen systemBgeehypothalamus1.00infobox
Duffy antigen systemBioGPSn/a1.00infobox
Duffy antigen systemChr.Chromosome 1 (human)1.00infobox
Duffy antigen systemChr.Chromosome 1 (mouse)1.00infobox
Duffy antigen systemDatabasesNCBI: entry; OMA: entry1.00infobox
Duffy antigen systemEnd159,206,500 bp1.00infobox
Duffy antigen systemEnd173,161,317 bp1.00infobox

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