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CCR5

C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines.

Clinical significance, Function & Structure

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Aliases
CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, C-C motif chemokine receptor 5 (gene/pseudogene), C-C motif chemokine receptor 5
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L87, 2RLL, 2RRS, 2MZX, 4MBS
Band
3p21.31 · 9 F4|9 75.05 cM
Bgee
epithelium of nasopharynx · parietal pleura · visceral pleura · palpebral conjunctiva · granulocyte
BioGPS
n/a
Chr.
Chromosome 3 (human) · Chromosome 9 (mouse)

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Overview

Tissue distribution

Structure

Function

Clinical significance

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Map overview Semantic statistics

CCR5

Nodes57
Edges56
Triples235
Avg. degree1.96
Density0.035088
Components1

How this topic connects Entity context

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CCR5

Top relations

Gene ontology · 44
CCR5 → actin binding, C-C chemokine binding, C-C chemokine receptor activity, calcium ion transport, calcium-mediated signaling, cell chemotaxis, cell surface, cell surface receptor signaling pathway, cell-cell signaling, cellular defense response, cellular response to lipopolysaccharide, chemokine (C-C motif) ligand 5 binding, chemokine binding, chemokine receptor activity, chemokine-mediated signaling pathway, chemotaxis, coreceptor activity, cytokine-mediated signaling pathway, cytoplasm, defense response
related to HIV · 29
CCR5 → Although, Because, CCR5-using, CD4, CXCR4, During HIV-1, Following, Gp120, Gp120-Gp41, Gp160, Gp41, HIV, HIV-1, In, MIP-1α, MIP-1β, Moreover, N-linked, RANTES, The
related to Structure · 24
CCR5 → CC, CCR5's, CXCR4, Cys101, Cys178, Cys20, Cys269, ECL1, ECL2, Glu283, GPCR, HIV-1, ICL1, III, MIP-1α, N-terminus, On, RANTES, The, The N-terminal
related to External links · 23
CCR5 → Archived, Basic, C-C, Chemokine Receptors, Clinical Pharmacology, HIV, HIVcoPred, International Union, Ion Channels, IUPHAR Database, January, July, Overview, P51681, PBS, PDB, PDBe-KB, PLoS ONE, Receptors, Retrieved
Bgee · 19
CCR5 → appendix, blastocyst, blood, embryo, epithelium of nasopharynx, germinal epithelium, granulocyte, jejunal mucosa, lumbar spinal ganglion, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, morula, mucosa of urinary bladder, palpebral conjunctiva, parietal pleura, submandibular gland, superficial temporal artery, visceral pleura
RNA expression pattern · 19
CCR5 → appendix, blastocyst, blood, embryo, epithelium of nasopharynx, germinal epithelium, granulocyte, jejunal mucosa, lumbar spinal ganglion, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, morula, mucosa of urinary bladder, palpebral conjunctiva, parietal pleura, submandibular gland, superficial temporal artery, visceral pleura
related to CCR5-Δ32 · 11
CCR5 → Caucasians, CCR5-Δ32, Despite, HIV, HIV-1, HIV-resistant, Individuals, Northern Europe, The, This, West Nile
related to Function · 10
CCR5 → CC, CCL3, CCL3L1, CCL4, CCL5, CCR5's, It, MIP, RANTES, The CCR5
related to Clinical significance · 8
CCR5 → African, CD4, HIV, It, Modulation, Regions, SIV, These
related to Stroke · 6
CCR5 → After, Blocking CCR5, HIV, In, Increased, Maraviroc

Important terminology Word statistics

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Important terminology

chemokine protein co-receptor receptor gene hiv-1 cells immune hiv also human infection cell expressed gp120 bp cancer binding virus receptors

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CCR5AliasesCCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, C-C motif chemokine receptor 5 (gene/pseudogene), C-C motif chemokine receptor 51.00infobox
CCR5Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L87, 2RLL, 2RRS, 2MZX, 4MBS1.00infobox
CCR5Band3p21.311.00infobox
CCR5Band9 F4|9 75.05 cM1.00infobox
CCR5Bgeeepithelium of nasopharynx1.00infobox
CCR5Bgeeparietal pleura1.00infobox
CCR5Bgeevisceral pleura1.00infobox
CCR5Bgeepalpebral conjunctiva1.00infobox
CCR5Bgeegranulocyte1.00infobox
CCR5Bgeegerminal epithelium1.00infobox
CCR5Bgeemucosa of urinary bladder1.00infobox
CCR5Bgeeappendix1.00infobox
CCR5Bgeesuperficial temporal artery1.00infobox
CCR5Bgeejejunal mucosa1.00infobox
CCR5Bgeelumbar subsegment of spinal cord1.00infobox
CCR5Bgeemorula1.00infobox
CCR5Bgeelumbar spinal ganglion1.00infobox
CCR5Bgeeblood1.00infobox
CCR5Bgeeembryo1.00infobox
CCR5Bgeelymph node1.00infobox
CCR5Bgeemesenteric lymph nodes1.00infobox
CCR5Bgeesubmandibular gland1.00infobox
CCR5Bgeeblastocyst1.00infobox
CCR5BioGPSn/a1.00infobox
CCR5Chr.Chromosome 3 (human)1.00infobox
CCR5Chr.Chromosome 9 (mouse)1.00infobox
CCR5DatabasesNCBI: entry; OMA: entry1.00infobox
CCR5End46,376,206 bp1.00infobox
CCR5End123,947,736 bp1.00infobox
CCR5EnsemblENSG000001607911.00infobox

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