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Platelet factor 4

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is…

Clinical significance, Function & Genomics

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Aliases
PF4, CXCL4, PF-4, SCYB4, platelet factor 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU
Band
4q13.3 · 5|5 E1
Bgee
monocyte · trabecular bone · granulocyte · blood · gonad
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 5 (mouse)

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Platelet factor 4

Nodes32
Edges31
Triples107
Avg. degree1.94
Density0.0625
Components1

How this topic connects Entity context

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Platelet factor 4

Top relations

Gene ontology · 40
Platelet factor 4 → adenylate cyclase-activating G protein-coupled receptor signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, cellular response to lipopolysaccharide, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, collagen-containing extracellular matrix, CXCR3 chemokine receptor binding, cytokine activity, cytokine-mediated signaling pathway, cytoplasm, defense response, extracellular region, extracellular space, G protein-coupled receptor signaling pathway, heparin binding, immune response, inflammatory response, leukocyte chemotaxis, negative regulation of angiogenesis
Bgee · 18
Platelet factor 4 → ankle, blood, bone marrow, bone marrow cell, carotid body, dermis, fetal liver hematopoietic progenitor cell, gonad, granulocyte, monocyte, periodontal fiber, sciatic nerve, spleen, stroma of bone marrow, testicle, tibiofemoral joint, trabecular bone, vestibular sensory epithelium
RNA expression pattern · 18
Platelet factor 4 → ankle, blood, bone marrow, bone marrow cell, carotid body, dermis, fetal liver hematopoietic progenitor cell, gonad, granulocyte, monocyte, periodontal fiber, sciatic nerve, spleen, stroma of bone marrow, testicle, tibiofemoral joint, trabecular bone, vestibular sensory epithelium
related to Antibodies · 7
Platelet factor 4 → At, HIT, Monoclonal, PF4, Platelet, The, There
Band · 2
Platelet factor 4 → 4q13.3, 5|5 E1
Chr. · 2
Platelet factor 4 → Chromosome 4 (human), Chromosome 5 (mouse)
End · 2
Platelet factor 4 → 73,982,027 bp, 90,921,242 bp
Aliases · 1
Platelet factor 4 → PF4, CXCL4, PF-4, SCYB4, platelet factor 4
Available structures · 1
Platelet factor 4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU
BioGPS · 1
Platelet factor 4 → More reference expression data

Important terminology Word statistics

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Important terminology

pf4 platelet human bp factor chr band chemokine chromosome gene also heparin blood location expression thrombocytopenia role cytokine antibodies mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Platelet factor 4AliasesPF4, CXCL4, PF-4, SCYB4, platelet factor 41.00infobox
Platelet factor 4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU1.00infobox
Platelet factor 4Band4q13.31.00infobox
Platelet factor 4Band5|5 E11.00infobox
Platelet factor 4Bgeemonocyte1.00infobox
Platelet factor 4Bgeetrabecular bone1.00infobox
Platelet factor 4Bgeegranulocyte1.00infobox
Platelet factor 4Bgeeblood1.00infobox
Platelet factor 4Bgeegonad1.00infobox
Platelet factor 4Bgeebone marrow1.00infobox
Platelet factor 4Bgeetesticle1.00infobox
Platelet factor 4Bgeebone marrow cell1.00infobox
Platelet factor 4Bgeeperiodontal fiber1.00infobox
Platelet factor 4Bgeespleen1.00infobox
Platelet factor 4Bgeetibiofemoral joint1.00infobox
Platelet factor 4Bgeesciatic nerve1.00infobox
Platelet factor 4Bgeestroma of bone marrow1.00infobox
Platelet factor 4Bgeefetal liver hematopoietic progenitor cell1.00infobox
Platelet factor 4Bgeedermis1.00infobox
Platelet factor 4Bgeeankle1.00infobox
Platelet factor 4Bgeevestibular sensory epithelium1.00infobox
Platelet factor 4Bgeecarotid body1.00infobox
Platelet factor 4BioGPSMore reference expression data1.00infobox
Platelet factor 4Chr.Chromosome 4 (human)1.00infobox
Platelet factor 4Chr.Chromosome 5 (mouse)1.00infobox
Platelet factor 4DatabasesNCBI: entry; OMA: entry1.00infobox
Platelet factor 4End73,982,027 bp1.00infobox
Platelet factor 4End90,921,242 bp1.00infobox
Platelet factor 4EnsemblENSG000001637371.00infobox
Platelet factor 4Entrez51961.00infobox

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