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Developmental toxicity

Developmental toxicity is any developmental malformation that is caused by the toxicity of a chemical or pathogen. It is the structural or functional alteration, reversible or irreversible, which interferes with homeostasis, normal growth, differentiation, development or behavior. Developmental toxicity is caused by environmental factors, things like…

History, Major developmental toxicants & Overview

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Overview

History

Testing and risk assessment

Examples

Major developmental toxicants

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  • ISBN ISBN (identifier)

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Map overview Semantic statistics

Developmental toxicity

Nodes113
Edges112
Triples84
Avg. degree1.98
Density0.017699
Components1

How this topic connects Entity context

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Developmental toxicity

Top relations

has effect · 21
Developmental toxicity → ACE, Alcohol, Anticonvulsant, DES, Developmental, Epigenetic, It, LeadDeath, Minor, Neural Tube Defects, Neurulation, NTD, Phenobarbitol, Polychlorinated Biphenyls, Polychlorinated BiphenylsFunctional, Retardation, Retinoic Acid, Rubella, The, This
related to Environmental endocrine disruptors · 12
Developmental toxicity → Another, Bisphenol, Both BPA, BPA, Endocrine, Many, More, One, Prenatal BPA, These, This, Vinclozolin
related to Dose Response · 7
Developmental toxicity → Benchmark, However, Human, It, LOAEL, NOAEL, The
related to Exposure Assessment · 5
Developmental toxicity → Exposure Assessment, Finally, First, Second, There
related to Hazard Identification · 4
Developmental toxicity → In, Route, The, There
related to Risk Characterization · 3
Developmental toxicity → Integration, Risk, To

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Important terminology

developmental exposure toxicity development effects pregnancy fetus chemicals cause thalidomide first known malformations human used study time toxicants lead also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
testicular developmentinstance ofsexual maturity0.80text
vaginal openinginstance ofsexual maturity0.80text
and the ability to reproduceinstance ofsexual maturity0.80text
weightinstance ofthe substance being studied is commonly introduced to pregnant animals appropriate to the study in different dosage during major organogenesis via oral route of exposure and mat…0.80text
ageinstance ofthe substance being studied is commonly introduced to pregnant animals appropriate to the study in different dosage during major organogenesis via oral route of exposure and mat…0.80text
and health status to reduces biasinstance ofthe substance being studied is commonly introduced to pregnant animals appropriate to the study in different dosage during major organogenesis via oral route of exposure and mat…0.80text
the endpoint of maternal toxicity can includes fertility indexinstance ofThe data are then used to interpret the endpoints of the manifestations above0.80text
mortalityinstance ofThe data are then used to interpret the endpoints of the manifestations above0.80text
gestation lengthinstance ofThe data are then used to interpret the endpoints of the manifestations above0.80text
and body weight changeinstance ofThe data are then used to interpret the endpoints of the manifestations above0.80text
and endpoint of developmental toxicityinstance ofThe data are then used to interpret the endpoints of the manifestations above0.80text
only focusing on one experimental doseinstance ofdue to limitation from both NOAEL and LOAEL0.80text

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