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Thalidomide

Thalidomide, sold under the brand names Contergan, Distaval and Thalomid among others, is an oral administered medication currently used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications of leprosy such as skin lesions). Thalidomide has been used to treat conditions associated…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L04AX02 (WHO)
Bioavailability
90%
CAS Number
50-35-1 Y
ChEBI
CHEBI:9513 N

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Overview

Medical uses

Contraindications

Adverse effects

Pharmacology

Chemistry

History

Society and culture

Research

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Map overview Semantic statistics

Thalidomide

Nodes180
Edges179
Triples166
Avg. degree1.99
Density0.011111
Components1

How this topic connects Entity context

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Thalidomide

Top relations

related to Thalidomide analogs · 19
Thalidomide → Additionally, Another, August, Celgene, Europe, European Commission, FDA, FDA-approved, February, Further, Imnovid, In, Interest, It, March, Pomalidomide, Revlimid, The, These
related to history · 18
Thalidomide → Chemical Industry Basel, Chemie Grünenthal, Contergan, German, Germany, Heinrich Mückter, Herbert Keller, In, It, Mueckter's, October, On, Researchers, The, The German, While, Wilhelm Kunz, World War II
related to Birth defect crisis · 14
Thalidomide → British Medical Journal, Concerns, December, Düsseldorf, Europe, In, In November, It, June, Leslie Florence, November, The, West Germany, Widukind Lenz
has treatment · 12
Thalidomide → Brazil, Brazilian, Despite, ENL, In, Israeli, Jacob Sheskin, Little, Nearly, Shortly, Since, The
related to Chemistry · 10
Thalidomide → As, Celgene Corporation, Celgene Corporation's, Cyclization, L-glutamic, L-glutamine, N-carbethoxyphthalimide, N-phthaloyl-L-glutamine, S-thalidomide, The
related to Quality of life · 10
Thalidomide → Access, Due, However, In, Individuals, Of, TE, The, These, When
has impact · 7
Thalidomide → FDA, Health, In, National Institute, This, US, US Federal Drug Administration
Legal status · 6
Thalidomide → AU: S4 (Prescription only), BR: Class C3 (Immunosuppressive drugs), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
has effect · 5
Thalidomide → Drug Administration, FDA, Food, The, There
related to Clinical research · 5
Thalidomide → Crohn's, Kaposi's, KSHV, Phase II, There

Important terminology Word statistics

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Important terminology

drug effects birth pregnancy born use fda treatment women people us market defects teratogenic risk used many clinical cancer leprosy

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Thalidomide3D model (JSmol)Interactive image1.00infobox
ThalidomideAHFS/Drugs.comMonograph1.00infobox
ThalidomideATC codeL04AX02 (WHO)1.00infobox
ThalidomideBioavailability90%1.00infobox
ThalidomideCAS Number50-35-1 Y1.00infobox
ThalidomideChEBICHEBI:9513 N1.00infobox
ThalidomideChEMBLChEMBL468 Y1.00infobox
ThalidomideChemSpider5233 Y1.00infobox
ThalidomideChiralityRacemic mixture1.00infobox
ThalidomideCompTox Dashboard (EPA)DTXSID90225241.00infobox
ThalidomideDrugBankDB01041 Y1.00infobox
ThalidomideECHA InfoCard100.000.0291.00infobox
ThalidomideElimination half-life5–7.5 hours (dose-dependent)1.00infobox
ThalidomideExcretionUrine, feces and semen1.00infobox
ThalidomideFormulaC13H10N2O41.00infobox
ThalidomideIUPHAR/BPS73271.00infobox
ThalidomideKEGGD00754 Y1.00infobox
ThalidomideLegal statusAU: S4 (Prescription only)1.00infobox
ThalidomideLegal statusBR: Class C3 (Immunosuppressive drugs)1.00infobox
ThalidomideLegal statusCA: ℞-only1.00infobox
ThalidomideLegal statusUK: POM (Prescription only)1.00infobox
ThalidomideLegal statusUS: ℞-only1.00infobox
ThalidomideLegal statusEU: Rx-only1.00infobox
ThalidomideLicense dataEU EMA: by INN1.00infobox
ThalidomideLicense dataUS DailyMed: Thalidomide1.00infobox
ThalidomideLicense dataUS FDA: Thalidomide1.00infobox
ThalidomideMedlinePlusa6990321.00infobox
ThalidomideMelting point270 °C (518 °F)1.00infobox
ThalidomideMetabolismLiver (minimally via CYP2C19-mediated 5-hydroxylation; mostly via non-enzymatic hydrolysis at the four amide sites)1.00infobox
ThalidomideMolar mass258.233 g·mol−11.00infobox

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