Thalidomide

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Thalidomide topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Thalidomide.

Related topics: 170
Source areas: 9
Connected nodes: 179
Extracted relationships: 166
Concept neighborhoods: 25
Bridge connections: 179

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 46 topics

History · 30 topics

Adverse effects · 27 topics

Research · 23 topics

Chemistry · 15 topics

Medical uses · 10 topics

Pharmacology · 10 topics

Society and culture · 8 topics

Contraindications · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
AHFS/Drugs.com: Monograph
ATC code: L04AX02 (WHO)
Bioavailability: 90%
CAS Number: 50-35-1 Y
ChEBI: CHEBI:9513 N

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Pharmacology

Chemistry

Society and culture

Research

Antiangiogenic
Analogs Functional analog (chemistry)
Lenalidomide
Myelosuppression
Pomalidomide
Apremilast
Thalidomide analogs Discovery and development of thalidomide and its analogs
Derivative Derivative (chemistry)
Immunomodulator
European Commission
Kaposi's sarcoma-associated herpesvirus
Renal cell carcinoma
Glioblastoma multiforme
Prostate cancer
Melanoma
Colorectal cancer
Crohn's disease
Rheumatoid arthritis
Behcet's syndrome
Breast cancer
Head and neck cancer
Ovarian cancer
Tuberculous meningitis

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Thalidomide connects Entity context

The extracted context around Thalidomide shows recurring relationship patterns in the source. For example, Thalidomide → Additionally, Another, August, Celgene, Europe, European Commission, FDA, FDA-approved, February, Further, Imnovid, In, Interest, It, March, Pomalidomide, Revlimid, The, These Another extracted example is Thalidomide → Chemical Industry Basel, Chemie Grünenthal, Contergan, German, Germany, Heinrich Mückter, Herbert Keller, In, It, Mueckter's, October, On, Researchers, The, The German, While, Wilhelm Kunz, World War II. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Thalidomide analogs · 19

Thalidomide → Additionally, Another, August, Celgene, Europe, European Commission, FDA, FDA-approved, February, Further, Imnovid, In, Interest, It, March, Pomalidomide, Revlimid, The, These

related to history · 18

Thalidomide → Chemical Industry Basel, Chemie Grünenthal, Contergan, German, Germany, Heinrich Mückter, Herbert Keller, In, It, Mueckter's, October, On, Researchers, The, The German, While, Wilhelm Kunz, World War II

related to Birth defect crisis · 14

Thalidomide → British Medical Journal, Concerns, December, Düsseldorf, Europe, In, In November, It, June, Leslie Florence, November, The, West Germany, Widukind Lenz

has treatment · 12

Thalidomide → Brazil, Brazilian, Despite, ENL, In, Israeli, Jacob Sheskin, Little, Nearly, Shortly, Since, The

related to Chemistry · 10

Thalidomide → As, Celgene Corporation, Celgene Corporation's, Cyclization, L-glutamic, L-glutamine, N-carbethoxyphthalimide, N-phthaloyl-L-glutamine, S-thalidomide, The

related to Quality of life · 10

Thalidomide → Access, Due, However, In, Individuals, Of, TE, The, These, When

has impact · 7

Thalidomide → FDA, Health, In, National Institute, This, US, US Federal Drug Administration

Legal status · 6

Thalidomide → AU: S4 (Prescription only), BR: Class C3 (Immunosuppressive drugs), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only

has effect · 5

Thalidomide → Drug Administration, FDA, Food, The, There

related to Clinical research · 5

Thalidomide → Crohn's, Kaposi's, KSHV, Phase II, There

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

drug effects birth pregnancy born use fda treatment women people us market defects teratogenic risk used many clinical cancer leprosy

Thalidomide relationships Subject–Predicate–Object triples

TTTA extracted 166 structured relationships around Thalidomide. Examples in this analysis include Thalidomide → 3D model (JSmol) → Interactive image and Thalidomide → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Thalidomide	3D model (JSmol)	Interactive image	1.00	infobox
Thalidomide	AHFS/Drugs.com	Monograph	1.00	infobox
Thalidomide	ATC code	L04AX02 (WHO)	1.00	infobox
Thalidomide	Bioavailability	90%	1.00	infobox
Thalidomide	CAS Number	50-35-1 Y	1.00	infobox
Thalidomide	ChEBI	CHEBI:9513 N	1.00	infobox
Thalidomide	ChEMBL	ChEMBL468 Y	1.00	infobox
Thalidomide	ChemSpider	5233 Y	1.00	infobox
Thalidomide	Chirality	Racemic mixture	1.00	infobox
Thalidomide	CompTox Dashboard (EPA)	DTXSID9022524	1.00	infobox
Thalidomide	DrugBank	DB01041 Y	1.00	infobox
Thalidomide	ECHA InfoCard	100.000.029	1.00	infobox
Thalidomide	Elimination half-life	5–7.5 hours (dose-dependent)	1.00	infobox
Thalidomide	Excretion	Urine, feces and semen	1.00	infobox
Thalidomide	Formula	C13H10N2O4	1.00	infobox
Thalidomide	IUPHAR/BPS	7327	1.00	infobox
Thalidomide	KEGG	D00754 Y	1.00	infobox
Thalidomide	Legal status	AU: S4 (Prescription only)	1.00	infobox
Thalidomide	Legal status	BR: Class C3 (Immunosuppressive drugs)	1.00	infobox
Thalidomide	Legal status	CA: ℞-only	1.00	infobox
Thalidomide	Legal status	UK: POM (Prescription only)	1.00	infobox
Thalidomide	Legal status	US: ℞-only	1.00	infobox
Thalidomide	Legal status	EU: Rx-only	1.00	infobox
Thalidomide	License data	EU EMA: by INN	1.00	infobox
Thalidomide	License data	US DailyMed: Thalidomide	1.00	infobox
Thalidomide	License data	US FDA: Thalidomide	1.00	infobox
Thalidomide	MedlinePlus	a699032	1.00	infobox
Thalidomide	Melting point	270 °C (518 °F)	1.00	infobox
Thalidomide	Metabolism	Liver (minimally via CYP2C19-mediated 5-hydroxylation; mostly via non-enzymatic hydrolysis at the four amide sites)	1.00	infobox
Thalidomide	Molar mass	258.233 g·mol−1	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Thalidomide bring nearby vocabulary together. In this analysis, examples include Birth, Pregnancy and Drug. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Thalidomide
- Birth
- Pregnancy
- Drug
- Use
- Born
- Cause
- Defects
- Used
- Risk
- Women
- Celgene
- Multiple
thalidomide
- Birth
- Pregnancy
- Drug
- Use
- Born
- Cause
- Defects
- Used
- Risk
- Women
- Celgene
- Multiple
multiple myeloma
- Myeloma
- Treatment
- Clinical
- Names
- People
- Leprosy
- Cancer
- Used
- Us
- Fda
- High
- Celgene
over-the-counter drug
- Women
- Us
- People
- Fda
- Thalidomide
- Drugs
- Time
- Clinical
- Used
- Market
- Pregnancy
- Treatment
thalidomide was found to cause birth defects
- Defects
- Pregnancy
- Risk
- Cancer
- Cause
- Use
- High
- Birth
- Thalidomide
- Drug
- Born
- Used
drug regulation
- Women
- Us
- People
- Fda
- Thalidomide
- Drugs
- Time
- Clinical
- Used
- Market
- Pregnancy
- Treatment
thalidomide trust
- Birth
- Pregnancy
- Drug
- Use
- Born
- Cause
- Defects
- Used
- Risk
- Women
- Celgene
- Multiple
causes birth defects
- Defects
- Pregnancy
- Risk
- Cause
- Use
- High
- Thalidomide
- Drug
- Women
- Children
- Names
- Many

Connections between topic areas Semantic bridges

For Thalidomide, one of the stronger structural bridges in this analysis connects Thalidomide with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Thalidomide — Overview · splits 133 ⟂ 47

Thalidomide — History · splits 149 ⟂ 31

Thalidomide — Adverse effects · splits 152 ⟂ 28

Thalidomide — Research · splits 156 ⟂ 24

Thalidomide — Chemistry · splits 164 ⟂ 16

Thalidomide — Medical uses · splits 169 ⟂ 11

Thalidomide — Pharmacology · splits 169 ⟂ 11

Thalidomide — Society and culture · splits 171 ⟂ 9

Map overview Semantic statistics

Thalidomide

Nodes180

Edges179

Triples166

Avg. degree1.99

Density0.011111

Components1

Source & methodology

TTTA analyzes the structure around Thalidomide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Thalidomide · EN edition · Analysis: TopicsToTalkAbout