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ERCC2

TFIIH subunit XPD is a protein that in humans is encoded by the ERCC2 (ERCC excision repair 2) gene. It is a component of the general transcription and DNA repair factor IIH (TFIIH) core complex involved in transcription-coupled nucleotide excision repair.

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5.6.2.3
Aliases
ERCC2, excision repair cross-complementation group 2, COFS2, EM9, TFIIH, TTD, XPD, TTD1, ERCC excision repair 2, TFIIH core complex helicase subunit
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IY9, 5IVW, 5IY7, 5IY8, 5IY6
Band
19q13.32 · 7 A3|7 9.62 cM
Bgee
stromal cell of endometrium · right adrenal gland · left adrenal gland · right adrenal cortex · ganglionic eminence
BioGPS
More reference expression data

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ERCC2

Nodes31
Edges30
Triples189
Avg. degree1.94
Density0.064516
Components1

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ERCC2

Top relations

Gene ontology · 85
ERCC2 → 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, 7-methylguanosine mRNA capping, ageing, apoptotic process, ATP binding, ATP-dependent activity, acting on DNA, bone mineralization, CAK-ERCC2 complex, cell population proliferation, cellular response to DNA damage stimulus, central nervous system myelin formation, chromosome segregation, cyclin-dependent protein kinase activating kinase holoenzyme complex, cytoplasm, cytoskeleton, cytosol, damaged DNA binding, DNA binding, DNA duplex unwinding
Bgee · 19
ERCC2 → epiblast, ganglionic eminence, Ileal epithelium, left adrenal cortex, left adrenal gland, left testis, lip, muscle of thigh, neural layer of retina, prefrontal cortex, right adrenal cortex, right adrenal gland, right testis, spermatid, spermatocyte, stromal cell of endometrium, superior frontal gyrus, ventricular zone, yolk sac
RNA expression pattern · 19
ERCC2 → epiblast, ganglionic eminence, Ileal epithelium, left adrenal cortex, left adrenal gland, left testis, lip, muscle of thigh, neural layer of retina, prefrontal cortex, right adrenal cortex, right adrenal gland, right testis, spermatid, spermatocyte, stromal cell of endometrium, superior frontal gyrus, ventricular zone, yolk sac
related to Function · 13
ERCC2 → DNA, ERCC3, IIH, Nucleotide, Such, TFIIH, The, The ERCC2/XPD, The XPD, With, XDP, XPB, XPD
related to Mutations · 10
ERCC2 → Cockayne, CS, DNA, ERCC2/XPD, Mutations, These, TTD, XP, XPCS, XPTTD
related to Xeroderma pigmentosum · 9
ERCC2 → DNA, Some, TFIIH, The, The XPD, United States, Various, Xeroderma, XP
related to External links · 6
ERCC2 → GeneReviews/NIH/NCBI/UW, Medicine Medical Subject Headings, MeSH, National Library, Protein, Xeroderma PigmentosumERCC2
related to Interactions · 3
ERCC2 → ERCC5, GTF2H1, GTF2H2
Band · 2
ERCC2 → 19q13.32, 7 A3|7 9.62 cM
Chr. · 2
ERCC2 → Chromosome 19 (human), Chromosome 7 (mouse)

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Important terminology

dna xpd gene repair tfiih protein xeroderma pigmentosum excision complex human nucleotide bp helicase transcription damage factor chr band damaged

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ERCC25.6.2.31.00infobox
ERCC2AliasesERCC2, excision repair cross-complementation group 2, COFS2, EM9, TFIIH, TTD, XPD, TTD1, ERCC excision repair 2, TFIIH core complex helicase subunit1.00infobox
ERCC2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IY9, 5IVW, 5IY7, 5IY8, 5IY61.00infobox
ERCC2Band19q13.321.00infobox
ERCC2Band7 A3|7 9.62 cM1.00infobox
ERCC2Bgeestromal cell of endometrium1.00infobox
ERCC2Bgeeright adrenal gland1.00infobox
ERCC2Bgeeleft adrenal gland1.00infobox
ERCC2Bgeeright adrenal cortex1.00infobox
ERCC2Bgeeganglionic eminence1.00infobox
ERCC2Bgeeleft adrenal cortex1.00infobox
ERCC2Bgeeventricular zone1.00infobox
ERCC2Bgeeright testis1.00infobox
ERCC2Bgeeleft testis1.00infobox
ERCC2Bgeeprefrontal cortex1.00infobox
ERCC2Bgeespermatocyte1.00infobox
ERCC2BgeeIleal epithelium1.00infobox
ERCC2Bgeeneural layer of retina1.00infobox
ERCC2Bgeeepiblast1.00infobox
ERCC2Bgeeyolk sac1.00infobox
ERCC2Bgeelip1.00infobox
ERCC2Bgeemuscle of thigh1.00infobox
ERCC2Bgeesuperior frontal gyrus1.00infobox
ERCC2Bgeespermatid1.00infobox
ERCC2BioGPSMore reference expression data1.00infobox
ERCC2Chr.Chromosome 19 (human)1.00infobox
ERCC2Chr.Chromosome 7 (mouse)1.00infobox
ERCC2DatabasesNCBI: entry; OMA: entry1.00infobox
ERCC2End45,370,918 bp1.00infobox
ERCC2End19,129,619 bp1.00infobox

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