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TFIIH subunit XPD is a protein that in humans is encoded by the ERCC2 (ERCC excision repair 2) gene. It is a component of the general transcription and DNA repair factor IIH (TFIIH) core complex involved in transcription-coupled nucleotide excision repair.
The analysis highlights Measurement, Overview and Interactions as prominent areas in the source structure around ERCC2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around ERCC2 shows recurring relationship patterns in the source. For example, ERCC2 → 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, 7-methylguanosine mRNA capping, ageing, apoptotic process, ATP binding, ATP-dependent activity, acting on DNA, bone mineralization, CAK-ERCC2 complex, cell population proliferation, cellular response to DNA damage stimulus, central nervous system myelin formation, chromosome segregation, cyclin-dependent protein kinase activating kinase holoenzyme complex, cytoplasm, cytoskeleton, cytosol, damaged DNA binding, DNA binding, DNA duplex unwinding Another extracted example is ERCC2 → epiblast, ganglionic eminence, Ileal epithelium, left adrenal cortex, left adrenal gland, left testis, lip, muscle of thigh, neural layer of retina, prefrontal cortex, right adrenal cortex, right adrenal gland, right testis, spermatid, spermatocyte, stromal cell of endometrium, superior frontal gyrus, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
dna xpd gene repair tfiih protein xeroderma pigmentosum excision complex human nucleotide bp helicase transcription damage factor chr band damaged
TTTA extracted 189 structured relationships around ERCC2. Examples in this analysis include ERCC2 → 5.6.2.3 → ↗ and ERCC2 → Aliases → ERCC2, excision repair cross-complementation group 2, COFS2, EM9, TFIIH, TTD, XPD, TTD1, ERCC excision repair 2, TFIIH core complex helicase subunit. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ERCC2 | 5.6.2.3 | ↗ | 1.00 | infobox |
| ERCC2 | Aliases | ERCC2, excision repair cross-complementation group 2, COFS2, EM9, TFIIH, TTD, XPD, TTD1, ERCC excision repair 2, TFIIH core complex helicase subunit | 1.00 | infobox |
| ERCC2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IY9, 5IVW, 5IY7, 5IY8, 5IY6 | 1.00 | infobox |
| ERCC2 | Band | 19q13.32 | 1.00 | infobox |
| ERCC2 | Band | 7 A3|7 9.62 cM | 1.00 | infobox |
| ERCC2 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| ERCC2 | Bgee | right adrenal gland | 1.00 | infobox |
| ERCC2 | Bgee | left adrenal gland | 1.00 | infobox |
| ERCC2 | Bgee | right adrenal cortex | 1.00 | infobox |
| ERCC2 | Bgee | ganglionic eminence | 1.00 | infobox |
| ERCC2 | Bgee | left adrenal cortex | 1.00 | infobox |
| ERCC2 | Bgee | ventricular zone | 1.00 | infobox |
| ERCC2 | Bgee | right testis | 1.00 | infobox |
| ERCC2 | Bgee | left testis | 1.00 | infobox |
| ERCC2 | Bgee | prefrontal cortex | 1.00 | infobox |
| ERCC2 | Bgee | spermatocyte | 1.00 | infobox |
| ERCC2 | Bgee | Ileal epithelium | 1.00 | infobox |
| ERCC2 | Bgee | neural layer of retina | 1.00 | infobox |
| ERCC2 | Bgee | epiblast | 1.00 | infobox |
| ERCC2 | Bgee | yolk sac | 1.00 | infobox |
| ERCC2 | Bgee | lip | 1.00 | infobox |
| ERCC2 | Bgee | muscle of thigh | 1.00 | infobox |
| ERCC2 | Bgee | superior frontal gyrus | 1.00 | infobox |
| ERCC2 | Bgee | spermatid | 1.00 | infobox |
| ERCC2 | BioGPS | More reference expression data | 1.00 | infobox |
| ERCC2 | Chr. | Chromosome 19 (human) | 1.00 | infobox |
| ERCC2 | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| ERCC2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ERCC2 | End | 45,370,918 bp | 1.00 | infobox |
| ERCC2 | End | 19,129,619 bp | 1.00 | infobox |
The concept neighborhoods around ERCC2 bring nearby vocabulary together. In this analysis, examples include Gene, Xpd and Pigmentosum. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For ERCC2, one of the stronger structural bridges in this analysis connects ERCC2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around ERCC2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Overview & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — ERCC2 · EN edition · Analysis: TopicsToTalkAbout