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Cytotoxic T-lymphocyte associated protein 4: History, Clinical significance & Function

Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is…

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Cytotoxic T-lymphocyte associated protein 4 topic overview

The analysis highlights History, Clinical significance and Function as prominent areas in the source structure around Cytotoxic T-lymphocyte associated protein 4.

Related topics
92
Source areas
6
Connected nodes
98
Extracted relationships
94
Concept neighborhoods
29
Bridge connections
98

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 29 topics
Overview · 24 topics
Function · 16 topics
Structure · 15 topics
History · 4 topics
Interactions · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7
Band
2q33.2 · 1 C2|1 30.58 cM
Bgee
lymph node · appendix · buccal mucosa cell · gonad · pancreatic epithelial cell
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Function

Structure

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Cytotoxic T-lymphocyte associated protein 4 connects Entity context

The extracted context around Cytotoxic T-lymphocyte associated protein 4 shows recurring relationship patterns in the source. For example, Cytotoxic T-lymphocyte associated protein 4 → adaptive immune response, B cell receptor signaling pathway, cellular response to DNA damage stimulus, clathrin-coated endocytic vesicle, external side of plasma membrane, Golgi apparatus, immune response, immune system process, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of B cell proliferation, negative regulation of immune response, negative regulation of regulatory T cell differentiation, negative regulation of T cell proliferation, perinuclear region of cytoplasm, plasma membrane, positive regulation of apoptotic process, protein binding, protein complex involved in cell adhesion Another extracted example is Cytotoxic T-lymphocyte associated protein 4 → appendix, buccal mucosa cell, colon, esophagus, gallbladder, gonad, granulocyte, ileum, jejunum, lymph node, pancreatic ductal cell, pancreatic epithelial cell, primary oocyte, secondary oocyte, spleen, superficial temporal artery, testicle, thymus, zone of skin, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Cytotoxic T-lymphocyte associated protein 4

Top relations

Gene ontology · 24
Cytotoxic T-lymphocyte associated protein 4 → adaptive immune response, B cell receptor signaling pathway, cellular response to DNA damage stimulus, clathrin-coated endocytic vesicle, external side of plasma membrane, Golgi apparatus, immune response, immune system process, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of B cell proliferation, negative regulation of immune response, negative regulation of regulatory T cell differentiation, negative regulation of T cell proliferation, perinuclear region of cytoplasm, plasma membrane, positive regulation of apoptotic process, protein binding, protein complex involved in cell adhesion
Bgee · 20
Cytotoxic T-lymphocyte associated protein 4 → appendix, buccal mucosa cell, colon, esophagus, gallbladder, gonad, granulocyte, ileum, jejunum, lymph node, pancreatic ductal cell, pancreatic epithelial cell, primary oocyte, secondary oocyte, spleen, superficial temporal artery, testicle, thymus, zone of skin, zygote
RNA expression pattern · 20
Cytotoxic T-lymphocyte associated protein 4 → appendix, buccal mucosa cell, colon, esophagus, gallbladder, gonad, granulocyte, ileum, jejunum, lymph node, pancreatic ductal cell, pancreatic epithelial cell, primary oocyte, secondary oocyte, spleen, superficial temporal artery, testicle, thymus, zone of skin, zygote
Band · 2
Cytotoxic T-lymphocyte associated protein 4 → 1 C2|1 30.58 cM, 2q33.2
Chr. · 2
Cytotoxic T-lymphocyte associated protein 4 → Chromosome 1 (mouse), Chromosome 2 (human)
End · 2
Cytotoxic T-lymphocyte associated protein 4 → 203,873,965 bp, 60,954,991 bp
Aliases · 1
Cytotoxic T-lymphocyte associated protein 4 → CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
Available structures · 1
Cytotoxic T-lymphocyte associated protein 4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7
BioGPS · 1
Cytotoxic T-lymphocyte associated protein 4 → More reference expression data
Databases · 1
Cytotoxic T-lymphocyte associated protein 4 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ctla-4 immune cells protein gene cd28 cd80 cell also bp cd86 regulatory ctla4 human function may dr chr band disease

Cytotoxic T-lymphocyte associated protein 4 relationships Subject–Predicate–Object triples

TTTA extracted 94 structured relationships around Cytotoxic T-lymphocyte associated protein 4. Examples in this analysis include Cytotoxic T-lymphocyte associated protein 4 → Aliases → CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4 and Cytotoxic T-lymphocyte associated protein 4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Cytotoxic T-lymphocyte associated protein 4AliasesCTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 41.00infobox
Cytotoxic T-lymphocyte associated protein 4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX71.00infobox
Cytotoxic T-lymphocyte associated protein 4Band2q33.21.00infobox
Cytotoxic T-lymphocyte associated protein 4Band1 C2|1 30.58 cM1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeelymph node1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeeappendix1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeebuccal mucosa cell1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeegonad1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeepancreatic epithelial cell1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeetesticle1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeegranulocyte1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeepancreatic ductal cell1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeesuperficial temporal artery1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeegallbladder1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeesecondary oocyte1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeezygote1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeethymus1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeeprimary oocyte1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeespleen1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeeileum1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeezone of skin1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeejejunum1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeeesophagus1.00infobox
Cytotoxic T-lymphocyte associated protein 4Bgeecolon1.00infobox
Cytotoxic T-lymphocyte associated protein 4BioGPSMore reference expression data1.00infobox
Cytotoxic T-lymphocyte associated protein 4Chr.Chromosome 2 (human)1.00infobox
Cytotoxic T-lymphocyte associated protein 4Chr.Chromosome 1 (mouse)1.00infobox
Cytotoxic T-lymphocyte associated protein 4DatabasesNCBI: entry; OMA: entry1.00infobox
Cytotoxic T-lymphocyte associated protein 4End203,873,965 bp1.00infobox
Cytotoxic T-lymphocyte associated protein 4End60,954,991 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Cytotoxic T-lymphocyte associated protein 4 bring nearby vocabulary together. In this analysis, examples include Cytotoxic, T-lymphocyte and Associated. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Cytotoxic T-lymphocyte associated protein 4
    • Cytotoxic
    • T-lymphocyte
    • Associated
    • Autoimmune
    • Protein
    • External
    • Disease
    • Chromosome
    • Location
    • Receptor
    • Bp
    • Chr
  • cytotoxic t-lymphocyte associated protein 4
    • Cytotoxic
    • T-lymphocyte
    • Associated
    • Autoimmune
    • Gene
    • Protein
    • External
    • Disease
    • Immune
    • Chromosome
    • Location
    • Receptor
  • protein receptor
    • Cell
    • T-lymphocyte
    • Immune
    • External
    • Chromosome
    • Expressed
    • Location
    • Receptor
    • Bp
    • Chr
    • Ctla4
    • Human
  • immune checkpoint
    • System
    • Protein
    • Ctla4
    • External
    • T-lymphocyte
    • Chromosome
    • Location
    • Negative
    • Receptor
    • Bp
    • Chr
    • Human
  • immune responses
    • System
    • Protein
    • Ctla4
    • External
    • T-lymphocyte
    • Chromosome
    • Location
    • Negative
    • Receptor
    • Bp
    • Chr
    • Human
  • fusion protein
    • T-lymphocyte
    • Immune
    • External
    • Chromosome
    • Location
    • Receptor
    • Bp
    • Chr
    • Ctla4
    • Human
    • Function
    • Regulatory
  • t cell receptor
    • Cell
    • Receptor
    • External
    • Expressed
    • First
    • System
    • T-lymphocyte
    • Ctla-4
    • Function
    • Regulatory
    • Band
    • Binding
  • immune checkpoint blockade
    • System
    • Protein
    • Ctla4
    • External
    • T-lymphocyte
    • Chromosome
    • Location
    • Negative
    • Receptor
    • Bp
    • Chr
    • Human

Connections between topic areas Semantic bridges

For Cytotoxic T-lymphocyte associated protein 4, one of the stronger structural bridges in this analysis connects Cytotoxic T-lymphocyte associated protein 4 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Cytotoxic T-lymphocyte associated protein 4Clinical significance · splits 69 ⟂ 30
Cytotoxic T-lymphocyte associated protein 4Overview · splits 74 ⟂ 25
Cytotoxic T-lymphocyte associated protein 4Function · splits 82 ⟂ 17
Cytotoxic T-lymphocyte associated protein 4Structure · splits 83 ⟂ 16
Cytotoxic T-lymphocyte associated protein 4History · splits 94 ⟂ 5
Cytotoxic T-lymphocyte associated protein 4Interactions · splits 94 ⟂ 5

Map overview Semantic statistics

Cytotoxic T-lymphocyte associated protein 4

Nodes99
Edges98
Triples94
Avg. degree1.98
Density0.020202
Components1

Source & methodology

TTTA analyzes the structure around Cytotoxic T-lymphocyte associated protein 4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Cytotoxic T-lymphocyte associated protein 4 · EN edition · Analysis: TopicsToTalkAbout

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