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Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is…
The analysis highlights History, Clinical significance and Function as prominent areas in the source structure around Cytotoxic T-lymphocyte associated protein 4.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Cytotoxic T-lymphocyte associated protein 4 shows recurring relationship patterns in the source. For example, Cytotoxic T-lymphocyte associated protein 4 → adaptive immune response, B cell receptor signaling pathway, cellular response to DNA damage stimulus, clathrin-coated endocytic vesicle, external side of plasma membrane, Golgi apparatus, immune response, immune system process, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of B cell proliferation, negative regulation of immune response, negative regulation of regulatory T cell differentiation, negative regulation of T cell proliferation, perinuclear region of cytoplasm, plasma membrane, positive regulation of apoptotic process, protein binding, protein complex involved in cell adhesion Another extracted example is Cytotoxic T-lymphocyte associated protein 4 → appendix, buccal mucosa cell, colon, esophagus, gallbladder, gonad, granulocyte, ileum, jejunum, lymph node, pancreatic ductal cell, pancreatic epithelial cell, primary oocyte, secondary oocyte, spleen, superficial temporal artery, testicle, thymus, zone of skin, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
ctla-4 immune cells protein gene cd28 cd80 cell also bp cd86 regulatory ctla4 human function may dr chr band disease
TTTA extracted 94 structured relationships around Cytotoxic T-lymphocyte associated protein 4. Examples in this analysis include Cytotoxic T-lymphocyte associated protein 4 → Aliases → CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4 and Cytotoxic T-lymphocyte associated protein 4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Cytotoxic T-lymphocyte associated protein 4 | Aliases | CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4 | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7 | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Band | 2q33.2 | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Band | 1 C2|1 30.58 cM | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | lymph node | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | appendix | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | buccal mucosa cell | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | gonad | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | pancreatic epithelial cell | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | testicle | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | granulocyte | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | pancreatic ductal cell | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | superficial temporal artery | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | gallbladder | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | secondary oocyte | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | zygote | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | thymus | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | primary oocyte | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | spleen | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | ileum | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | zone of skin | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | jejunum | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | esophagus | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Bgee | colon | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | BioGPS | More reference expression data | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | End | 203,873,965 bp | 1.00 | infobox |
| Cytotoxic T-lymphocyte associated protein 4 | End | 60,954,991 bp | 1.00 | infobox |
The concept neighborhoods around Cytotoxic T-lymphocyte associated protein 4 bring nearby vocabulary together. In this analysis, examples include Cytotoxic, T-lymphocyte and Associated. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Cytotoxic T-lymphocyte associated protein 4, one of the stronger structural bridges in this analysis connects Cytotoxic T-lymphocyte associated protein 4 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Cytotoxic T-lymphocyte associated protein 4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Cytotoxic T-lymphocyte associated protein 4 · EN edition · Analysis: TopicsToTalkAbout