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Two-photon excitation microscopy (TPEF or 2PEF) is a fluorescence imaging technique that is particularly well-suited to image scattering living tissue of up to about one millimeter in thickness. Unlike traditional fluorescence microscopy, where the excitation wavelength is shorter than the emission wavelength, two-photon excitation requires simultaneous…
Applications & Art
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two-photon excitation microscopy laser fluorescence imaging also used photons absorption tissue light confocal multiphoton due 2pef using image dyes optical
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| laser scanning confocal microscopy | instance of | Isaac Abella showed in 1962 in caesium vapor that two-photon excitation of single atoms is possible.Two-photon excitation fluorescence microscopy has similarities to other confo… | 0.80 | text |
| Raman microscopy | instance of | Isaac Abella showed in 1962 in caesium vapor that two-photon excitation of single atoms is possible.Two-photon excitation fluorescence microscopy has similarities to other confo… | 0.80 | text |
| pinholes to reject out-of-focus fluorescence | instance of | which need to employ elements | 0.80 | text |
| isolated cells | instance of | For very thin objects | 0.80 | text |
| single-photon | instance of | For very thin objects | 0.80 | text |
| glutamate | instance of | for photopharmacology including localized uncaging of components | 0.80 | text |
| GABA or isomerization of photoswitchable drugs | instance of | for photopharmacology including localized uncaging of components | 0.80 | text |
| and for the imaging of other genetically encoded sensors that report the concentration of neurotransmitters.Currently | instance of | for photopharmacology including localized uncaging of components | 0.80 | text |
| two-photon microscopy is widely used to image the live firing of neurons in model organisms including fruit flies | instance of | for photopharmacology including localized uncaging of components | 0.80 | text |
| Seta-670 | instance of | squaraine dyes | 0.80 | text |
| Seta-700 | instance of | squaraine dyes | 0.80 | text |
| Seta-660 exhibit very high 2-photon absorption | instance of | squaraine dyes | 0.80 | text |
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