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Circular RNA: Characters, Characteristics of circular RNA & Plausible functions

In molecular biology, circular ribonucleic acid (or circRNA) is a type of single-stranded RNA which, unlike linear RNA, forms a covalently closed continuous loop. In circular RNA, the 3' and 5' ends normally present in an RNA molecule have been joined together. This feature confers numerous properties to circular RNA, many of which have only recently…

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Circular RNA topic overview

The analysis highlights Characters, Characteristics of circular RNA and Plausible functions as prominent areas in the source structure around Circular RNA.

Related topics
109
Source areas
10
Connected nodes
119
Extracted relationships
75
Related term clusters
27
Bridge connections
119

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 53 topics
Plausible functions · 19 topics
Characteristics of circular RNA · 17 topics
Splicing · 7 topics
Disease · 5 topics
Myogenesis regulation · 3 topics
Origin · 2 topics
Immune response · 1 topics
Impact of RNA editing · 1 topics
Viroids · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Splicing

Impact of RNA editing

Characteristics of circular RNA

Plausible functions

Disease

Immune response

Myogenesis regulation

Viroids

Origin

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Circular RNA connects Entity context

The extracted context around Circular RNA shows recurring relationship patterns in the source. For example, Circular RNA → ANRIL, Circular ANRIL, Circular RNAs, Expression, Given, HIV, HIV-1, INK4/ARF, Parkinson's, Perhaps CiRS-7's, RNA, SRSF1, SRSF1's, Subsequently, Vpr Another extracted example is Circular RNA → AGO, Argonaut, Argonaute, CDR1as/CiRS-7, Certain, Detail, Family, HITS-CLIP, MicroRNAs, Protein, RNA, RNAs, Two. Use these groups to spot repeated connection types before inspecting the individual relationships.

Circular RNA

Top relations

related to Disease · 15
Circular RNA → ANRIL, Circular ANRIL, Circular RNAs, Expression, Given, HIV, HIV-1, INK4/ARF, Parkinson's, Perhaps CiRS-7's, RNA, SRSF1, SRSF1's, Subsequently, Vpr
related to CDR1as/CiRS-7 as a miR-7 sponge · 13
Circular RNA → AGO, Argonaut, Argonaute, CDR1as/CiRS-7, Certain, Detail, Family, HITS-CLIP, MicroRNAs, Protein, RNA, RNAs, Two
related to Early discoveries · 8
Circular RNA → CircRNA, DCC, ETS-1, P450, RNA ANRIL, RNAs, Shbg, Sry
related to Immune response · 7
Circular RNA → CD8, IL-1β, IL-6, Plasma, RNA, TNFa, Treatment
related to Myogenesis regulation · 7
Circular RNA → CaMKIId, CircSVIL, HDAC4, MEF2A, SRF, Wnt, Wnt5a
related to Evolutionary conservation of circularization mechanisms and signals · 5
Circular RNA → Archaea, CircRNAs, Danan, RNA, RNase
related to Length · 4
Circular RNA → Alu, Compared, Introns, RNAs
related to Location in the cell · 3
Circular RNA → CiRS-7/CDR1as, RNA, RNAs
related to Origin · 2
Circular RNA → RNA, Thus
related to Classes · 1
Circular RNA → Circular RNAs

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

rna circular circrnas circrna found rnas exons genes protein disease expression human expressed cell also linear alu role gene cancer

Circular RNA relationships Subject–Predicate–Object triples

TTTA extracted 75 structured relationships around Circular RNA. Examples in this analysis include circ-ITCH which regulates lung cancer associated with oncogenic sponges miR7 → instance of → some CircRNAs show positive effects and Epstein Barr virus → instance of → Some viruses. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
circ-ITCH which regulates lung cancer associated with oncogenic sponges miR7instance ofsome CircRNAs show positive effects0.80text
miR214instance ofsome CircRNAs show positive effects0.80text
overexpression of circ-ITCH inhibits cell proliferation in lung cancerinstance ofsome CircRNAs show positive effects0.80text
Epstein Barr virusinstance ofSome viruses0.80text
human papillomavirus can encode circular RNAs such asinstance ofSome viruses0.80text
circRBFOX2instance ofMyogenesis regulationCircular RNA plays an important role in myogenesis mechanisms0.80text
circLMO7 acts as a negative regulatorinstance ofMyogenesis regulationCircular RNA plays an important role in myogenesis mechanisms0.80text
CircSVIL acts as a positive regulator. circRBFOX2 regulates miR-206 expressioninstance ofMyogenesis regulationCircular RNA plays an important role in myogenesis mechanisms0.80text
induces myoblast proliferation in a negative effect on the myogenesis process. circLMO7 is involved in overexpression of HDAC4instance ofMyogenesis regulationCircular RNA plays an important role in myogenesis mechanisms0.80text
downregulates MEF2A expression by upregulating miR-378a-3p leading to myoblast differentiationinstance ofMyogenesis regulationCircular RNA plays an important role in myogenesis mechanisms0.80text
Circular RNArelated to CDR1as/CiRS-7 as a miR-7 spongeRNAs0.60section
Circular RNArelated to CDR1as/CiRS-7 as a miR-7 spongeMicroRNAs0.60section

Related concept clusters Related term clusters

The concept neighborhoods around Circular RNA bring nearby vocabulary together. In this analysis, examples include Rna, Rnas and Found. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Circular RNA
    • Rna
    • Rnas
    • Found
    • Role
    • Human
    • Disease
    • Used
    • Linear
    • Mirna
    • Sponge
    • Also
    • Cell
  • circular rna
    • Rna
    • Rnas
    • Found
    • Human
    • Disease
    • Role
    • Formation
    • Used
    • Linear
    • Mirna
    • Sponge
    • Also
  • rna
    • Human
    • Disease
    • Formation
    • Role
    • Found
    • Rnas
    • Cell
    • Protein
    • Circrnas
    • Biomarker
    • Elements
    • Splicing
  • gene regulators
    • Linear
    • Cells
    • Cirs-7
    • Sponge
    • Rna
    • Protein
    • Expression
    • Human
    • Cdr1as
    • Biomarker
    • Introns
    • Potential
  • cancer
    • Biomarker
    • Cells
    • Cirs-7
    • Exon
    • Cell
    • Found
    • Rna
    • Disease
    • Circrnas
    • Circular
    • Cdr1as
    • Circularization
  • cdr1as
    • Cirs-7
    • Mir-7
    • Sponge
    • Potential
    • Mirna
    • Protein
    • Circrnas
    • Rnas
    • Circularization
    • Elements
    • Introns
    • Splicing
  • breast cancer
    • Biomarker
    • Cells
    • Cirs-7
    • Exon
    • Cell
    • Found
    • Rna
    • Disease
    • Circrnas
    • Circular
    • Cdr1as
    • Circularization
  • messenger rna
    • Human
    • Disease
    • Formation
    • Role
    • Found
    • Rnas
    • Cell
    • Protein
    • Circrnas
    • Biomarker
    • Elements
    • Splicing

Connections between topic areas Semantic bridges

For Circular RNA, one of the stronger structural bridges in this analysis connects Circular RNA with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Circular RNA — Overview · splits 66 ⟂ 54
Circular RNA — Plausible functions · splits 100 ⟂ 20
Circular RNA — Characteristics of circular RNA · splits 102 ⟂ 18
Circular RNA — Splicing · splits 112 ⟂ 8
Circular RNA — Disease · splits 114 ⟂ 6
Circular RNA — Myogenesis regulation · splits 116 ⟂ 4
Circular RNA — Origin · splits 117 ⟂ 3

Map overview Semantic statistics

Circular RNA

Nodes120
Edges119
Triples75
Avg. degree1.98
Density0.016667
Components1

Source & methodology

TTTA analyzes the structure around Circular RNA to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Characters, Characteristics of circular RNA & Plausible functions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Circular RNA · EN edition · Analysis: TopicsToTalkAbout

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