Sex-determining region Y protein

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Gene evolution and regulation

Gene duplication X chromosome SOX3 SOX family Monotremes

20 related topics

SRY disorders' influence on sex expression

Karyotype Klinefelter syndrome Genetic recombination Crossover Swyer syndrome

30 related topics

Function

Urogenital ridge Follicle Theca FGF9 Nuclear localization sequences

14 related topics

Overview

DNA-binding protein Transcription factor Gene Sex determination Therian

30 related topics

Key facts & relationships

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Aliases: SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HRY, 1HRZ, 1J46, 1J47, 2GZK
Band: Yp11.2 · Y|Ypter
Bgee: gonad · tendon of biceps brachii · right testis · left testis · skin of abdomen
BioGPS: More reference expression data
Chr.: Y chromosome (human) · Y chromosome (mouse)

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Overview

DNA-binding protein
Transcription factor
Gene
Sex determination Sex chromosome
Therian Theria
Mammals Mammal
Placentals
Marsupials Marsupial
Intronless Intron
Sex Biological sex
Y chromosome
Mutations Mutation
Disorders of sex development
Phenotype
Genotype
SOX (SRY-like box) gene SOX genes
DNA
Steroidogenic factor 1 (SF-1) protein Steroidogenic factor 1
Upregulation
SOX9
Expression Gene expression
Sex cords Sex cord
Seminiferous tubules Seminiferous tubule
Gonad
Testis
Leydig cells Leydig cell
Testosterone
Sertoli cells Sertoli cell
Anti-Müllerian hormone
Secondary sexual characteristics

Gene evolution and regulation

Function

Urogenital ridge
Follicle Ovarian follicle
Theca Theca of follicle
FGF9
Nuclear localization sequences Nuclear localization sequence
C-terminal C-terminus
N-terminal N-terminus
Nuclear localization
Acetylation
Importin β
Calmodulin
Prostaglandin D2 synthase
Prostaglandin D2
Positive feedback

SRY disorders' influence on sex expression

Karyotype
Klinefelter syndrome
Genetic recombination
Crossover Chromosomal crossover
Swyer syndrome
XX male syndrome
Interact Protein–protein interaction
Androgen receptor
Androgen insensitivity Androgen insensitivity syndrome
Dopamine
Schizophrenia
Parkinson's disease
Megacolon
Hirschsprung disease
Campomelic dysplasia
Chondrogenesis
Olympic Games
International Olympic Committee
1996 Summer Olympics
False positives Type I and type II errors
American Medical Association
2000 Summer Olympics
World Athletics
Cheek swabbing
CAIS Complete androgen insensitivity syndrome
Swyer's syndrome XY gonadal dysgenesis
Microarray Microarray analysis techniques
Chromatin immunoprecipitation
Knockout models Knockout model
CRISPR-Cas9

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Nodes99

Edges98

Triples106

Avg. degree1.98

Density0.020202

Components1

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Sex-determining region Y protein

Top relations

Gene ontology · 25

Sex-determining region Y protein → calmodulin binding, cell differentiation, central nervous system development, cytoplasm, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, male sex determination, negative regulation of transcription by RNA polymerase II, neuron differentiation, nuclear speck, nucleoplasm, nucleus, positive regulation of gene expression, positive regulation of male gonad development, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein binding, regulation of transcription by RNA polymerase II

Bgee · 20

Sex-determining region Y protein → Achilles tendon, ankle joint, aortic valve, ascending aorta, condyle, cumulus cell, epithelium of small intestine, gonad, Ileal epithelium, islet of Langerhans, lacrimal gland, left testis, right adrenal cortex, right testis, salivary gland, skin of abdomen, skin of leg, supraoptic nucleus, tendon of biceps brachii, ventricular zone

RNA expression pattern · 20

related to External links · 12

Sex-determining region Y protein → Genes, Human Sex-determining, Medicine Medical Subject Headings, MeSH, National Library, OMIM, PDB, Protein, Region, Sex DevelopmentPDBe-KB, Sex-Determining, XX Testicular Disorder

Band · 2

Sex-determining region Y protein → Yp11.2, Y|Ypter

Chr. · 2

Sex-determining region Y protein → Y chromosome (human), Y chromosome (mouse)

End · 2

Sex-determining region Y protein → 2,663,658 bp, 2,787,682 bp

Aliases · 1

Sex-determining region Y protein → SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y

Available structures · 1

Sex-determining region Y protein → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HRY, 1HRZ, 1J46, 1J47, 2GZK

BioGPS · 1

Sex-determining region Y protein → More reference expression data

Important terminology Word statistics

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Important terminology

sry gene sex sox9 transcription development male factor chromosome protein also testis region human female bp binding xx xy individuals

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Sex-determining region Y protein	Aliases	SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y	1.00	infobox
Sex-determining region Y protein	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HRY, 1HRZ, 1J46, 1J47, 2GZK	1.00	infobox
Sex-determining region Y protein	Band	Yp11.2	1.00	infobox
Sex-determining region Y protein	Band	Y\|Ypter	1.00	infobox
Sex-determining region Y protein	Bgee	gonad	1.00	infobox
Sex-determining region Y protein	Bgee	tendon of biceps brachii	1.00	infobox
Sex-determining region Y protein	Bgee	right testis	1.00	infobox
Sex-determining region Y protein	Bgee	left testis	1.00	infobox
Sex-determining region Y protein	Bgee	skin of abdomen	1.00	infobox
Sex-determining region Y protein	Bgee	islet of Langerhans	1.00	infobox
Sex-determining region Y protein	Bgee	Achilles tendon	1.00	infobox
Sex-determining region Y protein	Bgee	skin of leg	1.00	infobox
Sex-determining region Y protein	Bgee	ventricular zone	1.00	infobox
Sex-determining region Y protein	Bgee	right adrenal cortex	1.00	infobox
Sex-determining region Y protein	Bgee	ankle joint	1.00	infobox
Sex-determining region Y protein	Bgee	ascending aorta	1.00	infobox
Sex-determining region Y protein	Bgee	aortic valve	1.00	infobox
Sex-determining region Y protein	Bgee	epithelium of small intestine	1.00	infobox
Sex-determining region Y protein	Bgee	cumulus cell	1.00	infobox
Sex-determining region Y protein	Bgee	Ileal epithelium	1.00	infobox
Sex-determining region Y protein	Bgee	supraoptic nucleus	1.00	infobox
Sex-determining region Y protein	Bgee	salivary gland	1.00	infobox
Sex-determining region Y protein	Bgee	condyle	1.00	infobox
Sex-determining region Y protein	Bgee	lacrimal gland	1.00	infobox
Sex-determining region Y protein	BioGPS	More reference expression data	1.00	infobox
Sex-determining region Y protein	Chr.	Y chromosome (human)	1.00	infobox
Sex-determining region Y protein	Chr.	Y chromosome (mouse)	1.00	infobox
Sex-determining region Y protein	Databases	NCBI: entry; OMA: entry	1.00	infobox
Sex-determining region Y protein	End	2,787,682 bp	1.00	infobox
Sex-determining region Y protein	End	2,663,658 bp	1.00	infobox

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