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Cyclin-dependent kinase 8

Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.

Interactions, Clinical significance & Function

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Interactions

15 related topics

Clinical significance

12 related topics

Function

8 related topics

As a potential drug target

8 related topics

Key facts & relationships

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2.7.11.22
2.7.11.23
Aliases
CDK8, K35, cyclin-dependent kinase 8, cyclin dependent kinase 8, IDDHBA
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3RGF, 4F6S, 4F6U, 4F6W, 4F70, 4F7J, 4F7L, 4F7N, 4F7S, 4G6L, 4CRL, 5HBH, 5CEI, 5FGK, 5HBE, 5BNJ, 5HBJ, 5HVY,…
Band
13q12.13 · 5|5 G3
Bgee
buccal mucosa cell · secondary oocyte · sperm · parietal pleura · endothelial cell

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Overview

Function

Clinical significance

As a potential drug target

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Cyclin-dependent kinase 8

Nodes51
Edges50
Triples88
Avg. degree1.96
Density0.039216
Components1

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Cyclin-dependent kinase 8

Top relations

Gene ontology · 22
Cyclin-dependent kinase 8 → ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, mediator complex, nucleolus, nucleoplasm, nucleotide binding, nucleus, phosphorylation, positive regulation of transcription by RNA polymerase II, protein binding, protein kinase activity, protein phosphorylation, protein serine/threonine kinase activity, protein-containing complex, regulation of cell cycle, regulation of mitotic cell cycle, regulation of transcription, DNA-templated, RNA polymerase II CTD heptapeptide repeat kinase activity, transcription initiation from RNA polymerase II promoter
Bgee · 19
Cyclin-dependent kinase 8 → amniotic fluid, buccal mucosa cell, endothelial cell, ganglionic eminence, jejunal mucosa, mandibular prominence, maxillary prominence, medullary collecting duct, muscle layer of sigmoid colon, Paneth cell, parietal pleura, primitive streak, secondary oocyte, somite, sperm, ureter, vestibular sensory epithelium, visceral pleura, zygote
RNA expression pattern · 19
Cyclin-dependent kinase 8 → amniotic fluid, buccal mucosa cell, endothelial cell, ganglionic eminence, jejunal mucosa, mandibular prominence, maxillary prominence, medullary collecting duct, muscle layer of sigmoid colon, Paneth cell, parietal pleura, primitive streak, secondary oocyte, somite, sperm, ureter, vestibular sensory epithelium, visceral pleura, zygote
Band · 2
Cyclin-dependent kinase 8 → 13q12.13, 5|5 G3
Chr. · 2
Cyclin-dependent kinase 8 → Chromosome 13 (human), Chromosome 5 (mouse)
End · 2
Cyclin-dependent kinase 8 → 146,239,684 bp, 26,405,238 bp
related to Interactions · 2
Cyclin-dependent kinase 8 → CCNCCREB, Cyclin-dependent
2.7.11.22 · 1
Cyclin-dependent kinase 8 → ↗
2.7.11.23 · 1
Cyclin-dependent kinase 8 → ↗
Aliases · 1
Cyclin-dependent kinase 8 → CDK8, K35, cyclin-dependent kinase 8, cyclin dependent kinase 8, IDDHBA

Important terminology Word statistics

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Important terminology

cdk8 gene human bp kinase chr band cell protein notch chromosome 13 location transcription cyclin-dependent binding mediator complex function activity

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Cyclin-dependent kinase 82.7.11.221.00infobox
Cyclin-dependent kinase 82.7.11.231.00infobox
Cyclin-dependent kinase 8AliasesCDK8, K35, cyclin-dependent kinase 8, cyclin dependent kinase 8, IDDHBA1.00infobox
Cyclin-dependent kinase 8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3RGF, 4F6S, 4F6U, 4F6W, 4F70, 4F7J, 4F7L, 4F7N, 4F7S, 4G6L, 4CRL, 5HBH, 5CEI, 5FGK, 5HBE, 5BNJ, 5HBJ, 5HVY,…1.00infobox
Cyclin-dependent kinase 8Band13q12.131.00infobox
Cyclin-dependent kinase 8Band5|5 G31.00infobox
Cyclin-dependent kinase 8Bgeebuccal mucosa cell1.00infobox
Cyclin-dependent kinase 8Bgeesecondary oocyte1.00infobox
Cyclin-dependent kinase 8Bgeesperm1.00infobox
Cyclin-dependent kinase 8Bgeeparietal pleura1.00infobox
Cyclin-dependent kinase 8Bgeeendothelial cell1.00infobox
Cyclin-dependent kinase 8Bgeemuscle layer of sigmoid colon1.00infobox
Cyclin-dependent kinase 8Bgeevisceral pleura1.00infobox
Cyclin-dependent kinase 8Bgeeamniotic fluid1.00infobox
Cyclin-dependent kinase 8Bgeejejunal mucosa1.00infobox
Cyclin-dependent kinase 8Bgeeganglionic eminence1.00infobox
Cyclin-dependent kinase 8Bgeeureter1.00infobox
Cyclin-dependent kinase 8Bgeeprimitive streak1.00infobox
Cyclin-dependent kinase 8Bgeezygote1.00infobox
Cyclin-dependent kinase 8Bgeemedullary collecting duct1.00infobox
Cyclin-dependent kinase 8Bgeemandibular prominence1.00infobox
Cyclin-dependent kinase 8BgeePaneth cell1.00infobox
Cyclin-dependent kinase 8Bgeesomite1.00infobox
Cyclin-dependent kinase 8Bgeevestibular sensory epithelium1.00infobox
Cyclin-dependent kinase 8Bgeemaxillary prominence1.00infobox
Cyclin-dependent kinase 8BioGPSMore reference expression data1.00infobox
Cyclin-dependent kinase 8Chr.Chromosome 13 (human)1.00infobox
Cyclin-dependent kinase 8Chr.Chromosome 5 (mouse)1.00infobox
Cyclin-dependent kinase 8DatabasesNCBI: entry; OMA: entry1.00infobox
Cyclin-dependent kinase 8End26,405,238 bp1.00infobox

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