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SCARB2

Lysosomal integral membrane protein 2 (LIMP-2) is a protein that in humans is encoded by the SCARB2 gene. LIMP-2 is expressed in brain, heart, liver, lung and kidney, mainly in the membrane of lysosome organelles; however, in cardiac muscle, LIMP-2 is also expressed at intercalated discs. LIMP-2 in a membrane protein in lysosomes that functions to…

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Aliases
SCARB2, AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII, scavenger receptor class B member 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4F7B, 4Q4B, 4Q4F, 4TVZ, 4TW0, 4TW2
Band
4q21.1 · 5|5 E2
Bgee
inferior ganglion of vagus nerve · subthalamic nucleus · germinal epithelium · superior vestibular nucleus · external globus pallidus
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 5 (mouse)

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Clinical significance

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Map overview Semantic statistics

SCARB2

Nodes60
Edges59
Triples104
Avg. degree1.97
Density0.033333
Components1

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SCARB2

Top relations

Gene ontology · 37
SCARB2 → aminophospholipid transport, cargo receptor activity, chaperone binding, cholesterol binding, clathrin-coated vesicle membrane, endocytic vesicle membrane, endoplasmic reticulum membrane, endosome membrane, enzyme binding, extracellular exosome, focal adhesion, Golgi membrane, integral component of membrane, late endosome membrane, lysosomal lumen, lysosomal membrane, lysosome, membrane, membrane organization, phosphatidylcholine binding
Bgee · 20
SCARB2 → arcuate nucleus, carotid body, ciliary body, deep cerebellar nuclei, dorsal tegmental nucleus, external globus pallidus, germinal epithelium, inferior ganglion of vagus nerve, iris, lactiferous duct, median eminence, pars compacta, pars reticulata, pons, right lung, subthalamic nucleus, superior vestibular nucleus, transitional epithelium of urinary bladder, trigeminal ganglion, ventral tegmental area
RNA expression pattern · 20
SCARB2 → arcuate nucleus, carotid body, ciliary body, deep cerebellar nuclei, dorsal tegmental nucleus, external globus pallidus, germinal epithelium, inferior ganglion of vagus nerve, iris, lactiferous duct, median eminence, pars compacta, pars reticulata, pons, right lung, subthalamic nucleus, superior vestibular nucleus, transitional epithelium of urinary bladder, trigeminal ganglion, ventral tegmental area
related to Clinical significance · 3
SCARB2 → In, LIMP-2, Mutations
Band · 2
SCARB2 → 4q21.1, 5|5 E2
Chr. · 2
SCARB2 → Chromosome 4 (human), Chromosome 5 (mouse)
End · 2
SCARB2 → 76,234,536 bp, 92,654,692 bp
Aliases · 1
SCARB2 → SCARB2, AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII, scavenger receptor class B member 2
Available structures · 1
SCARB2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4F7B, 4Q4B, 4Q4F, 4TVZ, 4TW0, 4TW2
BioGPS · 1
SCARB2 → More reference expression data

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Important terminology

limp-2 lysosomal human protein membrane bp gene chr band shown also heart kidney lysosomes rat intercalated cause failure chromosome mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SCARB2AliasesSCARB2, AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII, scavenger receptor class B member 21.00infobox
SCARB2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4F7B, 4Q4B, 4Q4F, 4TVZ, 4TW0, 4TW21.00infobox
SCARB2Band4q21.11.00infobox
SCARB2Band5|5 E21.00infobox
SCARB2Bgeeinferior ganglion of vagus nerve1.00infobox
SCARB2Bgeesubthalamic nucleus1.00infobox
SCARB2Bgeegerminal epithelium1.00infobox
SCARB2Bgeesuperior vestibular nucleus1.00infobox
SCARB2Bgeeexternal globus pallidus1.00infobox
SCARB2Bgeepons1.00infobox
SCARB2Bgeepars reticulata1.00infobox
SCARB2Bgeepars compacta1.00infobox
SCARB2Bgeelactiferous duct1.00infobox
SCARB2Bgeetrigeminal ganglion1.00infobox
SCARB2Bgeetransitional epithelium of urinary bladder1.00infobox
SCARB2Bgeeiris1.00infobox
SCARB2Bgeecarotid body1.00infobox
SCARB2Bgeeciliary body1.00infobox
SCARB2Bgeemedian eminence1.00infobox
SCARB2Bgeeright lung1.00infobox
SCARB2Bgeearcuate nucleus1.00infobox
SCARB2Bgeeventral tegmental area1.00infobox
SCARB2Bgeedeep cerebellar nuclei1.00infobox
SCARB2Bgeedorsal tegmental nucleus1.00infobox
SCARB2BioGPSMore reference expression data1.00infobox
SCARB2Chr.Chromosome 4 (human)1.00infobox
SCARB2Chr.Chromosome 5 (mouse)1.00infobox
SCARB2DatabasesNCBI: entry; OMA: entry1.00infobox
SCARB2End76,234,536 bp1.00infobox
SCARB2End92,654,692 bp1.00infobox

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