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CD19

B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19. In humans, CD19 is expressed in all B lineage cells. Contrary to some early doubts, human plasma cells do express CD19. CD19…

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Aliases
CD19, B4, CVID3, CD19 molecule
Band
16p11.2 · 7 F3|7 69.01 cM
Bgee
spleen · lymph node · appendix · granulocyte · mucosa of ileum
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 7 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Structure

Expression

Function

Interactions

In disease

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Map overview Semantic statistics

CD19

Nodes95
Edges94
Triples195
Avg. degree1.98
Density0.021053
Components1

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CD19

Top relations

Gene ontology · 28
CD19 → adaptive immune response, antigen receptor-mediated signaling pathway, B cell mediated immunity, B cell proliferation involved in immune response, B cell receptor signaling pathway, B-1 B cell differentiation, cell surface receptor signaling pathway, cellular defense response, external side of plasma membrane, extracellular exosome, immune system process, immunoglobulin mediated immune response, integral component of membrane, integral component of plasma membrane, membrane, membrane raft, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, plasma membrane, positive regulation of phosphatidylinositol 3-kinase activity
related to BCR-dependent · 21
CD19 → Activated, Akt, BCR, BCR-associated, BCRs, BLNK, C3, CD19/CD21, CD21, II, In, MHC, PI3K, Recognition, SH2-containing, Src-family, Syk, The, This, Varying
Bgee · 17
CD19 → appendix, blood, bone marrow, bone marrow cell, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, morula, mucosa of ileum, spleen, subcutaneous adipose tissue, testicle, thymus, tonsil, tunica adventitia of aorta, tunica media of zone of aorta
RNA expression pattern · 17
CD19 → appendix, blood, bone marrow, bone marrow cell, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, morula, mucosa of ileum, spleen, subcutaneous adipose tissue, testicle, thymus, tonsil, tunica adventitia of aorta, tunica media of zone of aorta
related to Structure · 16
CD19 → C-terminus, C2-set Ig-like, C2-type Ig-like, Experiments, Ig-like, IgSF, In, It, N-linked, Phenylalanine, The, Type, Within, Y391, Y482, Y513
related to BCR-independent · 15
CD19 → Akt, B-lineage, BCR, BCR-independent, BCR-negative, CD19-MYC, MYC, MYC-driven, Paired, Part, PAX5, PI3K, PI3K-AKT-GSK3β, The Akt-GSK3β, Using
related to Cancer · 15
CD19 → ALL, B-cell, CAR-19, CARs, CD19-specific, CD19-targeted, CLL, However, MYC, NHL, Non-Hodgkin's Lymphoma, Since CD19, TCR, The, This
related to Autoimmunity & immunodeficiency · 11
CD19 → Additionally, Additionally CD19, CD19/CD21, CD21, CD81, Down, MHC Class II, Mouse, Mutations, Researchers, These
related to Role in development & survival · 11
CD19 → Analysis, B-1, BCR, BCR-induced, Decisions, Essential, Experiments, MZ, The, These, Ultimately
related to CD19/CD21 complex · 8
CD19 → C3d, CD21, CD225, CD81, CR2, On, TAPA-1, The CD19/CD21

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Important terminology

cells cell signaling protein human cd21 expression complex antigen gene bcr bp development differentiation surface receptor activation chr band target

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD19AliasesCD19, B4, CVID3, CD19 molecule1.00infobox
CD19Band16p11.21.00infobox
CD19Band7 F3|7 69.01 cM1.00infobox
CD19Bgeespleen1.00infobox
CD19Bgeelymph node1.00infobox
CD19Bgeeappendix1.00infobox
CD19Bgeegranulocyte1.00infobox
CD19Bgeemucosa of ileum1.00infobox
CD19Bgeeepithelium of nasopharynx1.00infobox
CD19Bgeebone marrow cell1.00infobox
CD19Bgeetesticle1.00infobox
CD19Bgeeblood1.00infobox
CD19Bgeetonsil1.00infobox
CD19Bgeemesenteric lymph nodes1.00infobox
CD19Bgeesubcutaneous adipose tissue1.00infobox
CD19Bgeebone marrow1.00infobox
CD19Bgeethymus1.00infobox
CD19Bgeetunica adventitia of aorta1.00infobox
CD19Bgeetunica media of zone of aorta1.00infobox
CD19Bgeemorula1.00infobox
CD19BioGPSMore reference expression data1.00infobox
CD19Chr.Chromosome 16 (human)1.00infobox
CD19Chr.Chromosome 7 (mouse)1.00infobox
CD19DatabasesNCBI: entry; OMA: entry1.00infobox
CD19End28,939,342 bp1.00infobox
CD19End126,014,061 bp1.00infobox
CD19EnsemblENSG000001774551.00infobox
CD19Entrez9301.00infobox
CD19External IDsOMIM: 107265; MGI: 88319; GeneCards: CD191.00infobox
CD19Gene location (Human)Gene location (Human)Chr.Chromosome 16 (human)Band16p11.2Start28,931,965 bpEnd28,939,342 bp1.00infobox

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