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CD19: Function, In disease & Structure

B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19. In humans, CD19 is expressed in all B lineage cells. Contrary to some early doubts, human plasma cells do express CD19. CD19…

Language: English [EN]
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CD19 topic overview

The analysis highlights Function, In disease and Structure as prominent areas in the source structure around CD19.

Related topics
88
Source areas
6
Connected nodes
94
Extracted relationships
195
Concept neighborhoods
28
Bridge connections
94

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 34 topics
In disease · 20 topics
Structure · 14 topics
Overview · 10 topics
Expression · 7 topics
Interactions · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CD19, B4, CVID3, CD19 molecule
Band
16p11.2 · 7 F3|7 69.01 cM
Bgee
spleen · lymph node · appendix · granulocyte · mucosa of ileum
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 7 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Expression

Function

Interactions

In disease

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD19 connects Entity context

The extracted context around CD19 shows recurring relationship patterns in the source. For example, CD19 → adaptive immune response, antigen receptor-mediated signaling pathway, B cell mediated immunity, B cell proliferation involved in immune response, B cell receptor signaling pathway, B-1 B cell differentiation, cell surface receptor signaling pathway, cellular defense response, external side of plasma membrane, extracellular exosome, immune system process, immunoglobulin mediated immune response, integral component of membrane, integral component of plasma membrane, membrane, membrane raft, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, plasma membrane, positive regulation of phosphatidylinositol 3-kinase activity Another extracted example is CD19 → Activated, Akt, BCR, BCR-associated, BCRs, BLNK, C3, CD19/CD21, CD21, II, In, MHC, PI3K, Recognition, SH2-containing, Src-family, Syk, The, This, Varying. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD19

Top relations

Gene ontology · 28
CD19 → adaptive immune response, antigen receptor-mediated signaling pathway, B cell mediated immunity, B cell proliferation involved in immune response, B cell receptor signaling pathway, B-1 B cell differentiation, cell surface receptor signaling pathway, cellular defense response, external side of plasma membrane, extracellular exosome, immune system process, immunoglobulin mediated immune response, integral component of membrane, integral component of plasma membrane, membrane, membrane raft, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, plasma membrane, positive regulation of phosphatidylinositol 3-kinase activity
related to BCR-dependent · 21
CD19 → Activated, Akt, BCR, BCR-associated, BCRs, BLNK, C3, CD19/CD21, CD21, II, In, MHC, PI3K, Recognition, SH2-containing, Src-family, Syk, The, This, Varying
Bgee · 17
CD19 → appendix, blood, bone marrow, bone marrow cell, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, morula, mucosa of ileum, spleen, subcutaneous adipose tissue, testicle, thymus, tonsil, tunica adventitia of aorta, tunica media of zone of aorta
RNA expression pattern · 17
CD19 → appendix, blood, bone marrow, bone marrow cell, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, morula, mucosa of ileum, spleen, subcutaneous adipose tissue, testicle, thymus, tonsil, tunica adventitia of aorta, tunica media of zone of aorta
related to Structure · 16
CD19 → C-terminus, C2-set Ig-like, C2-type Ig-like, Experiments, Ig-like, IgSF, In, It, N-linked, Phenylalanine, The, Type, Within, Y391, Y482, Y513
related to BCR-independent · 15
CD19 → Akt, B-lineage, BCR, BCR-independent, BCR-negative, CD19-MYC, MYC, MYC-driven, Paired, Part, PAX5, PI3K, PI3K-AKT-GSK3β, The Akt-GSK3β, Using
related to Cancer · 15
CD19 → ALL, B-cell, CAR-19, CARs, CD19-specific, CD19-targeted, CLL, However, MYC, NHL, Non-Hodgkin's Lymphoma, Since CD19, TCR, The, This
related to Autoimmunity & immunodeficiency · 11
CD19 → Additionally, Additionally CD19, CD19/CD21, CD21, CD81, Down, MHC Class II, Mouse, Mutations, Researchers, These
related to Role in development & survival · 11
CD19 → Analysis, B-1, BCR, BCR-induced, Decisions, Essential, Experiments, MZ, The, These, Ultimately
related to CD19/CD21 complex · 8
CD19 → C3d, CD21, CD225, CD81, CR2, On, TAPA-1, The CD19/CD21

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells cell signaling protein human cd21 expression complex antigen gene bcr bp development differentiation surface receptor activation chr band target

CD19 relationships Subject–Predicate–Object triples

TTTA extracted 195 structured relationships around CD19. Examples in this analysis include CD19 → Aliases → CD19, B4, CVID3, CD19 molecule and CD19 → Band → 16p11.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD19AliasesCD19, B4, CVID3, CD19 molecule1.00infobox
CD19Band16p11.21.00infobox
CD19Band7 F3|7 69.01 cM1.00infobox
CD19Bgeespleen1.00infobox
CD19Bgeelymph node1.00infobox
CD19Bgeeappendix1.00infobox
CD19Bgeegranulocyte1.00infobox
CD19Bgeemucosa of ileum1.00infobox
CD19Bgeeepithelium of nasopharynx1.00infobox
CD19Bgeebone marrow cell1.00infobox
CD19Bgeetesticle1.00infobox
CD19Bgeeblood1.00infobox
CD19Bgeetonsil1.00infobox
CD19Bgeemesenteric lymph nodes1.00infobox
CD19Bgeesubcutaneous adipose tissue1.00infobox
CD19Bgeebone marrow1.00infobox
CD19Bgeethymus1.00infobox
CD19Bgeetunica adventitia of aorta1.00infobox
CD19Bgeetunica media of zone of aorta1.00infobox
CD19Bgeemorula1.00infobox
CD19BioGPSMore reference expression data1.00infobox
CD19Chr.Chromosome 16 (human)1.00infobox
CD19Chr.Chromosome 7 (mouse)1.00infobox
CD19DatabasesNCBI: entry; OMA: entry1.00infobox
CD19End28,939,342 bp1.00infobox
CD19End126,014,061 bp1.00infobox
CD19EnsemblENSG000001774551.00infobox
CD19Entrez9301.00infobox
CD19External IDsOMIM: 107265; MGI: 88319; GeneCards: CD191.00infobox
CD19Gene location (Human)Gene location (Human)Chr.Chromosome 16 (human)Band16p11.2Start28,931,965 bpEnd28,939,342 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD19 bring nearby vocabulary together. In this analysis, examples include Cells, Cell and Signaling. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD19
    • Cells
    • Cell
    • Signaling
    • Expression
    • Protein
    • Complex
    • Surface
    • Cd21
    • Gene
    • Activation
    • Bcr
    • Development
  • cd19
    • Cells
    • Cell
    • Signaling
    • Expression
    • Protein
    • Complex
    • Surface
    • Cd21
    • Gene
    • Activation
    • Bcr
    • Development
  • cluster of differentiation
    • Expressed
    • Plasma
    • Immune
    • Protein
    • Gene
    • Cell
    • Surface
    • Expression
    • Band
    • Chromosome
    • Function
    • Location
  • transmembrane protein
    • Signaling
    • Receptor
    • Surface
    • Cell
    • Complex
    • Plays
    • Complement
    • Gene
    • Activation
    • Human
    • Cd21
    • Akt
  • adaptor protein
    • Signaling
    • Receptor
    • Surface
    • Cell
    • Complex
    • Plays
    • Complement
    • Gene
    • Activation
    • Human
    • Cd21
    • Akt
  • b cell receptor
    • Complement
    • Surface
    • Cells
    • Receptor
    • Signaling
    • Protein
    • Differentiation
    • Activation
    • Complex
    • Expression
    • Band
    • Chromosome
  • gene rearrangement
    • Location
    • Human
    • Chromosome
    • Mouse
    • Bp
    • Chr
    • Surface
    • Band
    • Function
    • Expression
    • Complex
    • Protein
  • hematopoietic stem cell
    • Cells
    • Receptor
    • Surface
    • Protein
    • Differentiation
    • Complex
    • Signaling
    • Expression
    • Activation
    • Express
    • Expressed
    • Function

Connections between topic areas Semantic bridges

For CD19, one of the stronger structural bridges in this analysis connects CD19 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD19Function · splits 60 ⟂ 35
CD19In disease · splits 74 ⟂ 21
CD19Structure · splits 80 ⟂ 15
CD19Overview · splits 84 ⟂ 11
CD19Expression · splits 87 ⟂ 8
CD19Interactions · splits 91 ⟂ 4

Map overview Semantic statistics

CD19

Nodes95
Edges94
Triples195
Avg. degree1.98
Density0.021053
Components1

Source & methodology

TTTA analyzes the structure around CD19 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, In disease & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD19 · EN edition · Analysis: TopicsToTalkAbout

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