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Complement component 3: Measurement, Function & Clinical significance

Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a central role in the complement system of vertebrate animals and contributes to innate immunity. In humans, it is encoded on chromosome 19 by a gene called C3.

Language: English [EN]
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Complement component 3 topic overview

The analysis highlights Measurement, Function and Clinical significance as prominent areas in the source structure around Complement component 3.

Related topics
42
Source areas
5
Connected nodes
47
Extracted relationships
120
Concept neighborhoods
21
Bridge connections
47

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 17 topics
Clinical significance · 14 topics
Overview · 8 topics
Biosynthesis · 2 topics
Regulation · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
C3, AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p, complement component 3, complement C3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1C3D, 1GHQ, 1W2S, 2A73, 2A74, 2GOX, 2I07, 2ICE, 2ICF, 2NOJ, 2QKI, 2WII, 2WIN, 2WY7, 2WY8, 2XQW, 2XWB,…
Band
19p13.3 · 17 D|17 29.72 cM
Bgee
parietal pleura · palpebral conjunctiva · right lobe of liver · germinal epithelium · pericardium
BioGPS
n/a
Chr.
Chromosome 19 (human) · Chromosome 17 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Biosynthesis

Regulation

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Complement component 3 connects Entity context

The extracted context around Complement component 3 shows recurring relationship patterns in the source. For example, Complement component 3 → blood microparticle, C5L2 anaphylatoxin chemotactic receptor binding, complement activation, complement activation, alternative pathway, complement activation, classical pathway, endopeptidase inhibitor activity, extracellular exosome, extracellular fluid, extracellular region, fatty acid metabolic process, G protein-coupled receptor signaling pathway, immune response, immune system process, inflammatory response, innate immune response, lipid metabolism, negative regulation of endopeptidase activity, plasma membrane, positive regulation of activation of membrane attack complex, positive regulation of angiogenesis Another extracted example is Complement component 3 → gallbladder, gastric mucosa, germinal epithelium, granulocyte, intercostal muscle, left adrenal cortex, left lobe of liver, left uterine tube, mesenteric lymph nodes, palpebral conjunctiva, parietal pleura, pericardium, peritoneum, right adrenal cortex, right lobe of liver, right lung, subcutaneous adipose tissue, superior surface of tongue, tunica adventitia of aorta, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.

Complement component 3

Top relations

Gene ontology · 36
Complement component 3 → blood microparticle, C5L2 anaphylatoxin chemotactic receptor binding, complement activation, complement activation, alternative pathway, complement activation, classical pathway, endopeptidase inhibitor activity, extracellular exosome, extracellular fluid, extracellular region, fatty acid metabolic process, G protein-coupled receptor signaling pathway, immune response, immune system process, inflammatory response, innate immune response, lipid metabolism, negative regulation of endopeptidase activity, plasma membrane, positive regulation of activation of membrane attack complex, positive regulation of angiogenesis
Bgee · 20
Complement component 3 → gallbladder, gastric mucosa, germinal epithelium, granulocyte, intercostal muscle, left adrenal cortex, left lobe of liver, left uterine tube, mesenteric lymph nodes, palpebral conjunctiva, parietal pleura, pericardium, peritoneum, right adrenal cortex, right lobe of liver, right lung, subcutaneous adipose tissue, superior surface of tongue, tunica adventitia of aorta, white adipose tissue
RNA expression pattern · 20
Complement component 3 → gallbladder, gastric mucosa, germinal epithelium, granulocyte, intercostal muscle, left adrenal cortex, left lobe of liver, left uterine tube, mesenteric lymph nodes, palpebral conjunctiva, parietal pleura, pericardium, peritoneum, right adrenal cortex, right lobe of liver, right lung, subcutaneous adipose tissue, superior surface of tongue, tunica adventitia of aorta, white adipose tissue
related to Structure · 13
Complement component 3 → Arginine, Asn-63, Asn-917, C3, C3a, C3b, Complement, N-linked, Several, The, The C3, These, Upon
Band · 2
Complement component 3 → 17 D|17 29.72 cM, 19p13.3
Chr. · 2
Complement component 3 → Chromosome 17 (mouse), Chromosome 19 (human)
End · 2
Complement component 3 → 57,535,136 bp, 6,730,562 bp
Aliases · 1
Complement component 3 → C3, AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p, complement component 3, complement C3
Available structures · 1
Complement component 3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1C3D, 1GHQ, 1W2S, 2A73, 2A74, 2GOX, 2I07, 2ICE, 2ICF, 2NOJ, 2QKI, 2WII, 2WIN, 2WY7, 2WY8, 2XQW, 2XWB,…
BioGPS · 1
Complement component 3 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

c3 complement c3b factor bp system human chromosome 19 chr band deficiency component protein gene c3a activation activated pathway alternative

Complement component 3 relationships Subject–Predicate–Object triples

TTTA extracted 120 structured relationships around Complement component 3. Examples in this analysis include Complement component 3 → Aliases → C3, AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p, complement component 3, complement C3 and Complement component 3 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1C3D, 1GHQ, 1W2S, 2A73, 2A74, 2GOX, 2I07, 2ICE, 2ICF, 2NOJ, 2QKI, 2WII, 2WIN, 2WY7, 2WY8, 2XQW, 2XWB,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Complement component 3AliasesC3, AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p, complement component 3, complement C31.00infobox
Complement component 3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1C3D, 1GHQ, 1W2S, 2A73, 2A74, 2GOX, 2I07, 2ICE, 2ICF, 2NOJ, 2QKI, 2WII, 2WIN, 2WY7, 2WY8, 2XQW, 2XWB,…1.00infobox
Complement component 3Band19p13.31.00infobox
Complement component 3Band17 D|17 29.72 cM1.00infobox
Complement component 3Bgeeparietal pleura1.00infobox
Complement component 3Bgeepalpebral conjunctiva1.00infobox
Complement component 3Bgeeright lobe of liver1.00infobox
Complement component 3Bgeegerminal epithelium1.00infobox
Complement component 3Bgeepericardium1.00infobox
Complement component 3Bgeeperitoneum1.00infobox
Complement component 3Bgeegastric mucosa1.00infobox
Complement component 3Bgeeleft uterine tube1.00infobox
Complement component 3Bgeeright adrenal cortex1.00infobox
Complement component 3Bgeeleft adrenal cortex1.00infobox
Complement component 3Bgeeleft lobe of liver1.00infobox
Complement component 3Bgeemesenteric lymph nodes1.00infobox
Complement component 3Bgeegallbladder1.00infobox
Complement component 3Bgeeintercostal muscle1.00infobox
Complement component 3Bgeetunica adventitia of aorta1.00infobox
Complement component 3Bgeesubcutaneous adipose tissue1.00infobox
Complement component 3Bgeesuperior surface of tongue1.00infobox
Complement component 3Bgeewhite adipose tissue1.00infobox
Complement component 3Bgeegranulocyte1.00infobox
Complement component 3Bgeeright lung1.00infobox
Complement component 3BioGPSn/a1.00infobox
Complement component 3Chr.Chromosome 19 (human)1.00infobox
Complement component 3Chr.Chromosome 17 (mouse)1.00infobox
Complement component 3DatabasesNCBI: entry; OMA: entry1.00infobox
Complement component 3End6,730,562 bp1.00infobox
Complement component 3End57,535,136 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Complement component 3 bring nearby vocabulary together. In this analysis, examples include System, Component and Alternative. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Complement component 3
    • System
    • Component
    • Alternative
    • C3
    • Activity
    • Function
    • Factor
    • Mouse
    • Pathway
    • Activation
    • Band
    • Blood
  • complement component 3
    • System
    • Immune
    • Location
    • Regulation
    • Activity
    • Function
    • Gene
    • Component
    • Alternative
    • Bp
    • Chr
    • Chromosome
  • complement system
    • System
    • Component
    • Alternative
    • C3
    • Activity
    • Function
    • Factor
    • Pathway
    • Activation
    • Blood
    • Classical
    • Immune
  • chromosome 19
    • Gene
    • Bp
    • Chr
    • Human
    • Location
    • Band
    • Mouse
    • Regulation
    • Component
    • Function
    • Classical
    • Immune
  • alternative complement activation
    • Pathway
    • Classical
    • System
    • Α-chain
    • Component
    • Alternative
    • Complement
    • Regulation
    • C3
    • Factor
    • C3a
    • Activity
  • blood
    • Immune
    • Component
    • Protein
    • System
    • Mouse
    • Called
    • Classical
    • Location
    • Regulation
    • Activity
    • Associated
    • Band
  • function
    • Immune
    • Location
    • Regulation
    • Gene
    • Bp
    • Chr
    • Human
    • System
    • Mouse
    • Classical
    • Activity
    • Associated
  • immune system
    • Function
    • Protein
    • System
    • Mouse
    • Classical
    • Location
    • Regulation
    • Activity
    • Associated
    • Band
    • Gene
    • Α-chain

Connections between topic areas Semantic bridges

For Complement component 3, one of the stronger structural bridges in this analysis connects Complement component 3 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Complement component 3Function · splits 30 ⟂ 18
Complement component 3Clinical significance · splits 33 ⟂ 15
Complement component 3Overview · splits 39 ⟂ 9
Complement component 3Biosynthesis · splits 45 ⟂ 3

Map overview Semantic statistics

Complement component 3

Nodes48
Edges47
Triples120
Avg. degree1.96
Density0.041667
Components1

Source & methodology

TTTA analyzes the structure around Complement component 3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Complement component 3 · EN edition · Analysis: TopicsToTalkAbout

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