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Complement component 3

Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a central role in the complement system of vertebrate animals and contributes to innate immunity. In humans, it is encoded on chromosome 19 by a gene called C3.

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Aliases
C3, AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p, complement component 3, complement C3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1C3D, 1GHQ, 1W2S, 2A73, 2A74, 2GOX, 2I07, 2ICE, 2ICF, 2NOJ, 2QKI, 2WII, 2WIN, 2WY7, 2WY8, 2XQW, 2XWB,…
Band
19p13.3 · 17 D|17 29.72 cM
Bgee
parietal pleura · palpebral conjunctiva · right lobe of liver · germinal epithelium · pericardium
BioGPS
n/a
Chr.
Chromosome 19 (human) · Chromosome 17 (mouse)

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Overview

Function

Biosynthesis

Regulation

Clinical significance

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Map overview Semantic statistics

Complement component 3

Nodes48
Edges47
Triples120
Avg. degree1.96
Density0.041667
Components1

How this topic connects Entity context

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Complement component 3

Top relations

Gene ontology · 36
Complement component 3 → blood microparticle, C5L2 anaphylatoxin chemotactic receptor binding, complement activation, complement activation, alternative pathway, complement activation, classical pathway, endopeptidase inhibitor activity, extracellular exosome, extracellular fluid, extracellular region, fatty acid metabolic process, G protein-coupled receptor signaling pathway, immune response, immune system process, inflammatory response, innate immune response, lipid metabolism, negative regulation of endopeptidase activity, plasma membrane, positive regulation of activation of membrane attack complex, positive regulation of angiogenesis
Bgee · 20
Complement component 3 → gallbladder, gastric mucosa, germinal epithelium, granulocyte, intercostal muscle, left adrenal cortex, left lobe of liver, left uterine tube, mesenteric lymph nodes, palpebral conjunctiva, parietal pleura, pericardium, peritoneum, right adrenal cortex, right lobe of liver, right lung, subcutaneous adipose tissue, superior surface of tongue, tunica adventitia of aorta, white adipose tissue
RNA expression pattern · 20
Complement component 3 → gallbladder, gastric mucosa, germinal epithelium, granulocyte, intercostal muscle, left adrenal cortex, left lobe of liver, left uterine tube, mesenteric lymph nodes, palpebral conjunctiva, parietal pleura, pericardium, peritoneum, right adrenal cortex, right lobe of liver, right lung, subcutaneous adipose tissue, superior surface of tongue, tunica adventitia of aorta, white adipose tissue
related to Structure · 13
Complement component 3 → Arginine, Asn-63, Asn-917, C3, C3a, C3b, Complement, N-linked, Several, The, The C3, These, Upon
Band · 2
Complement component 3 → 17 D|17 29.72 cM, 19p13.3
Chr. · 2
Complement component 3 → Chromosome 17 (mouse), Chromosome 19 (human)
End · 2
Complement component 3 → 57,535,136 bp, 6,730,562 bp
Aliases · 1
Complement component 3 → C3, AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p, complement component 3, complement C3
Available structures · 1
Complement component 3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1C3D, 1GHQ, 1W2S, 2A73, 2A74, 2GOX, 2I07, 2ICE, 2ICF, 2NOJ, 2QKI, 2WII, 2WIN, 2WY7, 2WY8, 2XQW, 2XWB,…
BioGPS · 1
Complement component 3 → n/a

Important terminology Word statistics

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Important terminology

c3 complement c3b factor bp system human chromosome 19 chr band deficiency component protein gene c3a activation activated pathway alternative

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Complement component 3AliasesC3, AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p, complement component 3, complement C31.00infobox
Complement component 3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1C3D, 1GHQ, 1W2S, 2A73, 2A74, 2GOX, 2I07, 2ICE, 2ICF, 2NOJ, 2QKI, 2WII, 2WIN, 2WY7, 2WY8, 2XQW, 2XWB,…1.00infobox
Complement component 3Band19p13.31.00infobox
Complement component 3Band17 D|17 29.72 cM1.00infobox
Complement component 3Bgeeparietal pleura1.00infobox
Complement component 3Bgeepalpebral conjunctiva1.00infobox
Complement component 3Bgeeright lobe of liver1.00infobox
Complement component 3Bgeegerminal epithelium1.00infobox
Complement component 3Bgeepericardium1.00infobox
Complement component 3Bgeeperitoneum1.00infobox
Complement component 3Bgeegastric mucosa1.00infobox
Complement component 3Bgeeleft uterine tube1.00infobox
Complement component 3Bgeeright adrenal cortex1.00infobox
Complement component 3Bgeeleft adrenal cortex1.00infobox
Complement component 3Bgeeleft lobe of liver1.00infobox
Complement component 3Bgeemesenteric lymph nodes1.00infobox
Complement component 3Bgeegallbladder1.00infobox
Complement component 3Bgeeintercostal muscle1.00infobox
Complement component 3Bgeetunica adventitia of aorta1.00infobox
Complement component 3Bgeesubcutaneous adipose tissue1.00infobox
Complement component 3Bgeesuperior surface of tongue1.00infobox
Complement component 3Bgeewhite adipose tissue1.00infobox
Complement component 3Bgeegranulocyte1.00infobox
Complement component 3Bgeeright lung1.00infobox
Complement component 3BioGPSn/a1.00infobox
Complement component 3Chr.Chromosome 19 (human)1.00infobox
Complement component 3Chr.Chromosome 17 (mouse)1.00infobox
Complement component 3DatabasesNCBI: entry; OMA: entry1.00infobox
Complement component 3End6,730,562 bp1.00infobox
Complement component 3End57,535,136 bp1.00infobox

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