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Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during the early stage of anaphase. In humans, separin is encoded by the ESPL1 gene.
History, Function & Regulation
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securin cohesin sister anaphase chromatids complex binding separin protein esp1 scc1 proteins gene cdk1-cyclin cohesion separation chromatid phosphorylation two substrate
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Separase | BRENDA | enzyme data | 1.00 | infobox |
| Separase | CAS no. | 351527-77-0 | 1.00 | infobox |
| Separase | EC no. | 3.4.22.49 | 1.00 | infobox |
| Separase | ExPASy | NiceZyme view | 1.00 | infobox |
| Separase | KEGG | enzyme entry | 1.00 | infobox |
| Separase | MetaCyc | metabolic pathway | 1.00 | infobox |
| Separase | NCBI | proteins | 1.00 | infobox |
| Separase | PDB structures | RCSB PDB PDBe PDBsum | 1.00 | infobox |
| Separase | PMC | articles | 1.00 | infobox |
| Separase | PubMed | articles | 1.00 | infobox |
| Separase | Rhea | reactions | 1.00 | infobox |
| Separase | Search | SearchPMCarticlesPubMedarticlesNCBIproteins | 1.00 | infobox |
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