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Bone morphogenetic protein 4: Clinical significance, Function & Overview

Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. BMP4 is found on chromosome 14q22-q23.

Language: English [EN]
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Bone morphogenetic protein 4 topic overview

The analysis highlights Clinical significance, Function and Overview as prominent areas in the source structure around Bone morphogenetic protein 4.

Related topics
87
Source areas
6
Connected nodes
93
Extracted relationships
275
Concept neighborhoods
27
Bridge connections
93

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 31 topics
Overview · 31 topics
Function · 14 topics
Inhibition · 7 topics
Discovery · 2 topics
Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, bone morphogenetic protein 4
Band
14 C1|14 23.95 cM
Bgee
meninges · semicircular canal · genital tubercle · surface ectoderm · abdominal wall
BioGPS
More reference expression data
Chr.
Chromosome 14 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Structure

Function

Inhibition

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Bone morphogenetic protein 4 connects Entity context

The extracted context around Bone morphogenetic protein 4 shows recurring relationship patterns in the source. For example, Bone morphogenetic protein 4 → anatomical structure formation involved in morphogenesis, angiogenesis, anterior/posterior axis specification, aortic valve morphogenesis, apoptotic process involved in endocardial cushion morphogenesis, blood vessel development, blood vessel endothelial cell proliferation involved in sprouting angiogenesis, BMP receptor binding, BMP signaling pathway, BMP signaling pathway involved in heart development, BMP signaling pathway involved in heart induction, BMP signaling pathway involved in nephric duct formation, BMP signaling pathway involved in renal system segmentation, BMP signaling pathway involved in ureter morphogenesis, bone development, branching involved in prostate gland morphogenesis, branching involved in ureteric bud morphogenesis, branching morphogenesis of an epithelial tube, bronchus development, bud dilation involved in lung branching Another extracted example is Bone morphogenetic protein 4 → Additionally, Bmp2, BMP4, Bone Morphogenetic Protein, However, In, In Msx1, Msx1, Natural, Other, Shh, Sonic, TGFβ, The, This, Transforming Growth Factor-beta. Use these groups to spot repeated connection types before inspecting the individual relationships.

Bone morphogenetic protein 4

Top relations

Gene ontology · 215
Bone morphogenetic protein 4 → anatomical structure formation involved in morphogenesis, angiogenesis, anterior/posterior axis specification, aortic valve morphogenesis, apoptotic process involved in endocardial cushion morphogenesis, blood vessel development, blood vessel endothelial cell proliferation involved in sprouting angiogenesis, BMP receptor binding, BMP signaling pathway, BMP signaling pathway involved in heart development, BMP signaling pathway involved in heart induction, BMP signaling pathway involved in nephric duct formation, BMP signaling pathway involved in renal system segmentation, BMP signaling pathway involved in ureter morphogenesis, bone development, branching involved in prostate gland morphogenesis, branching involved in ureteric bud morphogenesis, branching morphogenesis of an epithelial tube, bronchus development, bud dilation involved in lung branching
related to Gene · 16
Bone morphogenetic protein 4 → Additionally, Bmp2, BMP4, Bone Morphogenetic Protein, However, In, In Msx1, Msx1, Natural, Other, Shh, Sonic, TGFβ, The, This, Transforming Growth Factor-beta
Bgee · 10
Bone morphogenetic protein 4 → abdominal wall, amnion, calvaria, external carotid artery, genital tubercle, meninges, migratory enteric neural crest cell, posterior semicircular canal, semicircular canal, surface ectoderm
RNA expression pattern · 10
Bone morphogenetic protein 4 → abdominal wall, amnion, calvaria, external carotid artery, genital tubercle, meninges, migratory enteric neural crest cell, posterior semicircular canal, semicircular canal, surface ectoderm
related to Clinical significance · 4
Bone morphogenetic protein 4 → BMP4, Fibrodysplasia Ossificans Progressiva, Increase, There
Aliases · 1
Bone morphogenetic protein 4 → BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, bone morphogenetic protein 4
Band · 1
Bone morphogenetic protein 4 → 14 C1|14 23.95 cM
BioGPS · 1
Bone morphogenetic protein 4 → More reference expression data
Chr. · 1
Bone morphogenetic protein 4 → Chromosome 14 (mouse)
Databases · 1
Bone morphogenetic protein 4 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bmp4 hair differentiation development signaling formation bone gene protein expression found growth lens noggin pathways follicle mice also smad expressed

Bone morphogenetic protein 4 relationships Subject–Predicate–Object triples

TTTA extracted 275 structured relationships around Bone morphogenetic protein 4. Examples in this analysis include Bone morphogenetic protein 4 → Aliases → BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, bone morphogenetic protein 4 and Bone morphogenetic protein 4 → Band → 14 C1|14 23.95 cM. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Bone morphogenetic protein 4AliasesBMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, bone morphogenetic protein 41.00infobox
Bone morphogenetic protein 4Band14 C1|14 23.95 cM1.00infobox
Bone morphogenetic protein 4Bgeemeninges1.00infobox
Bone morphogenetic protein 4Bgeesemicircular canal1.00infobox
Bone morphogenetic protein 4Bgeegenital tubercle1.00infobox
Bone morphogenetic protein 4Bgeesurface ectoderm1.00infobox
Bone morphogenetic protein 4Bgeeabdominal wall1.00infobox
Bone morphogenetic protein 4Bgeeposterior semicircular canal1.00infobox
Bone morphogenetic protein 4Bgeemigratory enteric neural crest cell1.00infobox
Bone morphogenetic protein 4Bgeeamnion1.00infobox
Bone morphogenetic protein 4Bgeecalvaria1.00infobox
Bone morphogenetic protein 4Bgeeexternal carotid artery1.00infobox
Bone morphogenetic protein 4BioGPSMore reference expression data1.00infobox
Bone morphogenetic protein 4Chr.Chromosome 14 (mouse)1.00infobox
Bone morphogenetic protein 4DatabasesNCBI: entry; OMA: entry1.00infobox
Bone morphogenetic protein 4End46,628,126 bp1.00infobox
Bone morphogenetic protein 4EnsemblENSG000001253781.00infobox
Bone morphogenetic protein 4Entrez6521.00infobox
Bone morphogenetic protein 4External IDsOMIM: 112262; MGI: 88180; GeneCards: BMP41.00infobox
Bone morphogenetic protein 4Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 14 (mouse)Band14 C1|14 23.95 cMStart46,620,977 bpEnd46,628,126 bp1.00infobox
Bone morphogenetic protein 4Gene ontologyheparin binding1.00infobox
Bone morphogenetic protein 4Gene ontologycytokine activity1.00infobox
Bone morphogenetic protein 4Gene ontologyco-receptor binding1.00infobox
Bone morphogenetic protein 4Gene ontologytransforming growth factor beta receptor binding1.00infobox
Bone morphogenetic protein 4Gene ontologygrowth factor activity1.00infobox
Bone morphogenetic protein 4Gene ontologyBMP receptor binding1.00infobox
Bone morphogenetic protein 4Gene ontologyprotein binding1.00infobox
Bone morphogenetic protein 4Gene ontologychemoattractant activity1.00infobox
Bone morphogenetic protein 4Gene ontologyextracellular region1.00infobox
Bone morphogenetic protein 4Gene ontologyextracellular space1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Bone morphogenetic protein 4 bring nearby vocabulary together. In this analysis, examples include Morphogenetic, Protein and Eye. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Bone morphogenetic protein 4
    • Morphogenetic
    • Protein
    • Eye
    • Gene
    • Formation
    • Involved
    • Growth
    • Development
    • Cell
    • Mapk
    • Mesoderm
    • Pathway
  • bone morphogenetic protein 4
    • Morphogenetic
    • Protein
    • Gene
    • Eye
    • Formation
    • Growth
    • Involved
    • Cell
    • Mapk
    • Mesoderm
    • Pathway
    • Patterning
  • gene
    • Morphogenetic
    • Protein
    • Involved
    • Tissue
    • Formation
    • Eye
    • Cell
    • Mapk
    • Mesoderm
    • Pathway
    • Patterning
    • Tooth
  • bone morphogenetic protein
    • Morphogenetic
    • Protein
    • Gene
    • Eye
    • Formation
    • Growth
    • Involved
    • Cell
    • Mapk
    • Mesoderm
    • Pathway
    • Patterning
  • transforming growth factor-beta
    • Morphogenetic
    • Hair
    • Protein
    • Signaling
    • Differentiation
    • Expression
    • Formation
    • Development
    • Eye
    • Cell
    • Mapk
    • Mesoderm
  • pluripotent stem cell
    • Neural
    • Eye
    • Mapk
    • Mesoderm
    • Pathway
    • Patterning
    • Transcription
    • Morphogenetic
    • Signal
    • Smad
    • Tissue
    • Expressed
  • bone extract
    • Morphogenetic
    • Protein
    • Eye
    • Gene
    • Formation
    • Involved
    • Growth
    • Development
    • Cell
    • Mapk
    • Mesoderm
    • Pathway
  • bone morphogenetic proteins
    • Morphogenetic
    • Protein
    • Gene
    • Eye
    • Formation
    • Growth
    • Involved
    • Cell
    • Mapk
    • Mesoderm
    • Pathway
    • Patterning

Connections between topic areas Semantic bridges

For Bone morphogenetic protein 4, one of the stronger structural bridges in this analysis connects Bone morphogenetic protein 4 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Bone morphogenetic protein 4Overview · splits 62 ⟂ 32
Bone morphogenetic protein 4Clinical significance · splits 62 ⟂ 32
Bone morphogenetic protein 4Function · splits 79 ⟂ 15
Bone morphogenetic protein 4Inhibition · splits 86 ⟂ 8
Bone morphogenetic protein 4Discovery · splits 91 ⟂ 3
Bone morphogenetic protein 4Structure · splits 91 ⟂ 3

Map overview Semantic statistics

Bone morphogenetic protein 4

Nodes94
Edges93
Triples275
Avg. degree1.98
Density0.021277
Components1

Source & methodology

TTTA analyzes the structure around Bone morphogenetic protein 4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Bone morphogenetic protein 4 · EN edition · Analysis: TopicsToTalkAbout

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