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Isocitrate dehydrogenase 1

Isocitrate dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which uses NAD+ as the electron acceptor and the other NADP+. Five isocitrate…

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1.1.1.42
Aliases
IDH1, HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD, isocitrate dehydrogenase (NADP(+)) 1, cytosolic, isocitrate dehydrogenase (NADP(+)) 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1T09, 1T0L, 3INM, 3MAP, 3MAR, 3MAS, 4I3K, 4I3L, 4KZO, 4L03, 4L04, 4L06, 4UMX, 4UMY, 4XRX, 5DE1, 4XS3, 5K10,…
Band
2q34 · 1 C2- C3|1 32.91 cM
Bgee
corpus epididymis · jejunal mucosa · right adrenal cortex · mucosa of sigmoid colon · left adrenal gland
BioGPS
n/a

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Isocitrate dehydrogenase 1

Nodes69
Edges68
Triples103
Avg. degree1.97
Density0.028986
Components1

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Isocitrate dehydrogenase 1

Top relations

Gene ontology · 38
Isocitrate dehydrogenase 1 → (R)-2-hydroxyglutarate dehydrogenase activity, 2-oxoglutarate metabolic process, cadherin binding, cytoplasm, cytosol, extracellular exosome, extracellular region, female gonad development, ficolin-1-rich granule lumen, glutathione metabolic process, glyoxylate cycle, identical protein binding, isocitrate dehydrogenase (NADP+) activity, isocitrate dehydrogenase activity, isocitrate metabolic process, magnesium ion binding, metal ion binding, mitochondrion, NAD binding, NADP binding
Bgee · 20
Isocitrate dehydrogenase 1 → adrenal gland, barrel cortex, caput epididymis, corpus epididymis, cumulus cell, duodenum, human kidney, jejunal mucosa, left adrenal cortex, left adrenal gland, left lobe of liver, medial ganglionic eminence, mucosa of sigmoid colon, pyloric antrum, right adrenal cortex, right kidney, secondary oocyte, seminal vesicula, superior cervical ganglion, transitional epithelium of urinary bladder
RNA expression pattern · 20
Isocitrate dehydrogenase 1 → adrenal gland, barrel cortex, caput epididymis, corpus epididymis, cumulus cell, duodenum, human kidney, jejunal mucosa, left adrenal cortex, left adrenal gland, left lobe of liver, medial ganglionic eminence, mucosa of sigmoid colon, pyloric antrum, right adrenal cortex, right kidney, secondary oocyte, seminal vesicula, superior cervical ganglion, transitional epithelium of urinary bladder
Band · 2
Isocitrate dehydrogenase 1 → 1 C2- C3|1 32.91 cM, 2q34
Chr. · 2
Isocitrate dehydrogenase 1 → Chromosome 1 (mouse), Chromosome 2 (human)
End · 2
Isocitrate dehydrogenase 1 → 208,266,074 bp, 65,225,659 bp
1.1.1.42 · 1
Isocitrate dehydrogenase 1 → ↗
Aliases · 1
Isocitrate dehydrogenase 1 → IDH1, HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD, isocitrate dehydrogenase (NADP(+)) 1, cytosolic, isocitrate dehydrogenase (NADP(+)) 1
Available structures · 1
Isocitrate dehydrogenase 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1T09, 1T0L, 3INM, 3MAP, 3MAR, 3MAS, 4I3K, 4I3L, 4KZO, 4L03, 4L04, 4L06, 4UMX, 4UMY, 4XRX, 5DE1, 4XS3, 5K10,…
BioGPS · 1
Isocitrate dehydrogenase 1 → n/a

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Important terminology

idh1 isocitrate enzyme nadp gene mutations active ivosidenib mutation nadph human also dehydrogenase site two bp function one chromosome cytoplasm

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Isocitrate dehydrogenase 11.1.1.421.00infobox
Isocitrate dehydrogenase 1AliasesIDH1, HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD, isocitrate dehydrogenase (NADP(+)) 1, cytosolic, isocitrate dehydrogenase (NADP(+)) 11.00infobox
Isocitrate dehydrogenase 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1T09, 1T0L, 3INM, 3MAP, 3MAR, 3MAS, 4I3K, 4I3L, 4KZO, 4L03, 4L04, 4L06, 4UMX, 4UMY, 4XRX, 5DE1, 4XS3, 5K10,…1.00infobox
Isocitrate dehydrogenase 1Band2q341.00infobox
Isocitrate dehydrogenase 1Band1 C2- C3|1 32.91 cM1.00infobox
Isocitrate dehydrogenase 1Bgeecorpus epididymis1.00infobox
Isocitrate dehydrogenase 1Bgeejejunal mucosa1.00infobox
Isocitrate dehydrogenase 1Bgeeright adrenal cortex1.00infobox
Isocitrate dehydrogenase 1Bgeemucosa of sigmoid colon1.00infobox
Isocitrate dehydrogenase 1Bgeeleft adrenal gland1.00infobox
Isocitrate dehydrogenase 1Bgeeleft adrenal cortex1.00infobox
Isocitrate dehydrogenase 1Bgeesecondary oocyte1.00infobox
Isocitrate dehydrogenase 1Bgeeduodenum1.00infobox
Isocitrate dehydrogenase 1Bgeeseminal vesicula1.00infobox
Isocitrate dehydrogenase 1Bgeecaput epididymis1.00infobox
Isocitrate dehydrogenase 1Bgeecumulus cell1.00infobox
Isocitrate dehydrogenase 1Bgeetransitional epithelium of urinary bladder1.00infobox
Isocitrate dehydrogenase 1Bgeeright kidney1.00infobox
Isocitrate dehydrogenase 1Bgeemedial ganglionic eminence1.00infobox
Isocitrate dehydrogenase 1Bgeeleft lobe of liver1.00infobox
Isocitrate dehydrogenase 1Bgeeadrenal gland1.00infobox
Isocitrate dehydrogenase 1Bgeehuman kidney1.00infobox
Isocitrate dehydrogenase 1Bgeepyloric antrum1.00infobox
Isocitrate dehydrogenase 1Bgeebarrel cortex1.00infobox
Isocitrate dehydrogenase 1Bgeesuperior cervical ganglion1.00infobox
Isocitrate dehydrogenase 1BioGPSn/a1.00infobox
Isocitrate dehydrogenase 1Chr.Chromosome 2 (human)1.00infobox
Isocitrate dehydrogenase 1Chr.Chromosome 1 (mouse)1.00infobox
Isocitrate dehydrogenase 1DatabasesNCBI: entry; OMA: entry1.00infobox
Isocitrate dehydrogenase 1End208,266,074 bp1.00infobox

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