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Lisdexamfetamine

Lisdexamfetamine, sold under the brand names Vyvanse (/ˈvaɪ.væns/, VY-vans) and Elvanse among others, is a stimulant medication that is used as a treatment for attention deficit hyperactivity disorder (ADHD) in both children and adults, and for moderate-to-severe binge eating disorder in adults. A prodrug of dextroamphetamine, lisdexamfetamine is taken…

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3D model (JSmol)
Interactive image
Addiction liability
Moderate
AHFS/Drugs.com
Monograph
ATC code
N06BA12 (WHO)
Bioavailability
Oral: 96.4%
Boiling point
Not applicable; decomposes before boiling

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Overview

Uses

Contraindications

Adverse effects

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

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Map overview Semantic statistics

Lisdexamfetamine

Nodes285
Edges284
Triples146
Avg. degree1.99
Density0.007018
Components1

How this topic connects Entity context

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Lisdexamfetamine

Top relations

related to Contraindications · 15
Lisdexamfetamine → ADHD, Amphetamine, Australian Therapeutic Goods Administration, Concerta, Drug Administration, European, However, In, It, MAOI, OROSTooltip, Pharmaceutical, Prescribing, United States Food, USFDA
related to history · 13
Lisdexamfetamine → ADHD, Drug Administration, FDA, Health Canada, In August, In February, It, New River Pharmaceuticals, NRP104, Robert Oberlender, Shire Pharmaceuticals, Takeda Pharmaceuticals, US Food
related to Interactions · 13
Lisdexamfetamine → Acidifying, Alkalinizing, Concomitant, CYP2D6, Drugs, Hydroxylation, MAOIs, Monoamine, Norepinephrine, NRIs, P450, Potent CYP2D6, Studies
related to Name · 12
Lisdexamfetamine → Aduvanz, As, Elvanse, INN, International Nonproprietary Name, Juneve, L-lysine-dextroamphetamine, November, Samexid, Tyvense, Venvanse, Vyvanse
Legal status · 9
Lisdexamfetamine → AU: S8 (Controlled drug), BR: Class A3 (Psychoactive drugs), CA: Controlled Drug (CDSA I), DE: Anlage III (Special prescription form required), EU: Rx-only, NZ: Class B, SE: Förteckning II, UK: Class B, US: Schedule II
related to Chemistry · 8
Lisdexamfetamine → Amine, In, IUPAC, L-lysinamide, L-lysine, The, There, This
related to Depression · 7
Lisdexamfetamine → Amphetamine, Clinical, In, Other, SNRI, Some, SSRI
related to Mechanism of action · 5
Lisdexamfetamine → After, L-lysine, Studies, TAAR1, The
is a · 4
Lisdexamfetamine → inactive prodrug that is formed by the condensation of L-lysine, only USFDA- and TGA-approved pharmacotherapy for BED, prodrug of dextroamphetamine, single-enantiomer dextroamphetamine formula similar to Dexedrine but opposed to other amphetamine based pharmaceuticals such as Adderall
has effect · 4
Lisdexamfetamine → Products, Rare, Rates, The

Important terminology Word statistics

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Important terminology

amphetamine dextroamphetamine adhd treatment use effects stimulant may disorder eating narcolepsy depression effective therapeutic used ph drug binge release trials

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Lisdexamfetamine3D model (JSmol)Interactive image1.00infobox
LisdexamfetamineAddiction liabilityModerate1.00infobox
LisdexamfetamineAHFS/Drugs.comMonograph1.00infobox
LisdexamfetamineATC codeN06BA12 (WHO)1.00infobox
LisdexamfetamineBioavailabilityOral: 96.4%1.00infobox
LisdexamfetamineBoiling pointNot applicable; decomposes before boiling1.00infobox
LisdexamfetamineCAS Number608137-32-2 Y[IUPHAR]1.00infobox
LisdexamfetamineChEMBLChEMBL1201222 Y1.00infobox
LisdexamfetamineChemSpider9772458 Y1.00infobox
LisdexamfetamineChiralityDextrorotatory enantiomer1.00infobox
LisdexamfetamineCompTox Dashboard (EPA)DTXSID002096521.00infobox
LisdexamfetamineDensityNot routinely reported for solid pharmaceutical salts1.00infobox
LisdexamfetamineDependence liabilityPhysical: None Psychological: Moderate1.00infobox
LisdexamfetamineDrug classNorepinephrine–dopamine releasing agent; Stimulant1.00infobox
LisdexamfetamineDrugBankDB01255 Y1.00infobox
LisdexamfetamineDuration of action10–14 hours1.00infobox
LisdexamfetamineElimination half-lifeLisdexamfetamine: <1 hour Dextroamphetamine: 10–12 h1.00infobox
LisdexamfetamineExcretionKidney: ~2% as Lisdexamfetamine and ~42% as Dextroamphetamine1.00infobox
LisdexamfetamineFormulaC15H25N3O1.00infobox
LisdexamfetamineIUPHAR/BPS72131.00infobox
LisdexamfetamineKEGGD081301.00infobox
LisdexamfetamineKEGGas salt: D047471.00infobox
LisdexamfetamineLegal statusAU: S8 (Controlled drug)1.00infobox
LisdexamfetamineLegal statusBR: Class A3 (Psychoactive drugs)1.00infobox
LisdexamfetamineLegal statusCA: Controlled Drug (CDSA I)1.00infobox
LisdexamfetamineLegal statusDE: Anlage III (Special prescription form required)1.00infobox
LisdexamfetamineLegal statusNZ: Class B1.00infobox
LisdexamfetamineLegal statusUK: Class B1.00infobox
LisdexamfetamineLegal statusUS: Schedule II1.00infobox
LisdexamfetamineLegal statusEU: Rx-only1.00infobox

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