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Aggresome

In eukaryotic cells, an aggresome refers to an aggregation of misfolded proteins in the cell, formed when the protein degradation system of the cell is overwhelmed. Aggresome formation is a highly regulated process that possibly serves to organize misfolded proteins into a single location.

Biogenesis, Human disease & Role of the aggresome pathway in cancer

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Overview

Biogenesis

Human disease

Role of the aggresome pathway in cancer

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Map overview Semantic statistics

Aggresome

Nodes52
Edges51
Triples72
Avg. degree1.96
Density0.038462
Components1

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Aggresome

Top relations

related to Further reading · 35
Aggresome → AB, Aggresome Formation, Aggresome Pathway, Aggresomes, Biol Chem, Cancer, Cellular Response, Chin, Cole, Curr Med Chem, D/Ealing, Dependent Protein DegradationZaarur, Dissecting, Gabai, Hartl, ISSN, JA, Li, LS, M802216200
related to Human disease · 15
Aggresome → Accumulation, Aggresome-forming, Alzheimer's, AR, Evidence, Experiments, Finally, Huntington's, In, Molecular, Mutant AR, Parkinson's, Together, Whether, X-linked
related to Triggering aggresome formation · 13
Aggresome → Abnormal, Analogously, Furthermore, HEK293, However, Hsp90, Importantly, On, Parkinson, Synphilin, Therefore, These, When
related to Cystic fibrosis · 5
Aggresome → CFTR, Chinese, Cystic, Overexpression, Undergraded CFTR
related to Role of the aggresome pathway in cancer · 1
Aggresome → There

Important terminology Word statistics

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Important terminology

protein proteins formation misfolded aggresomes cells forms function degradation aggregates synphilin disease proteasome aggregation pathway cytoplasmic linked response inclusion bodies

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
p62 are believed to be involved in aggresome formation in sequestering omega-somesinstance ofMediators0.80text
which bindinstance ofMediators0.80text
increase the size of the aggresomeinstance ofMediators0.80text
Aggresomerelated to Cystic fibrosisCystic0.60section
Aggresomerelated to Cystic fibrosisCFTR0.60section
Aggresomerelated to Cystic fibrosisOverexpression0.60section
Aggresomerelated to Cystic fibrosisChinese0.60section
Aggresomerelated to Cystic fibrosisUndergraded CFTR0.60section
Aggresomerelated to Further readingAggresomes0.60section
Aggresomerelated to Further readingCellular Response0.60section
Aggresomerelated to Further readingMisfolded ProteinsAggresomes0.60section
Aggresomerelated to Further readingJA0.60section

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