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Hyperforin

Hyperforin is a phytochemical produced by some of the members of the plant genus Hypericum, notably Hypericum perforatum (St John's wort). Hyperforin may be involved in the pharmacological effects of St. John's wort, specifically in its antidepressant effects. Meta-analyses of clinical trials suggest that H. perforatum is as effective as SSRIs for…

Pharmacodynamics, Chemistry & Pharmacokinetics

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3D model (JSmol)
Interactive image
ATC code
none
CAS Number
11079-53-1
ChEBI
CHEBI:5834 Y
ChemSpider
16736597 Y
CompTox Dashboard (EPA)
DTXSID90891409

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Overview

Occurrence

Chemistry

Pharmacokinetics

Pharmacodynamics

Biosynthesis

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Map overview Semantic statistics

Hyperforin

Nodes46
Edges45
Triples66
Avg. degree1.96
Density0.043478
Components1

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Hyperforin

Top relations

related to Chemistry · 12
Hyperforin → Bio-organic Chemistry, C3, C8, C9, Frequent, In, Moscow, PPAP, Sciences, Shemyakin Institute, The, USSR Academy
related to Pharmacodynamics · 9
Hyperforin → CYP2C9, CYP3A4, GABA, IC50, In, John's, MRI, P450, St
related to Pharmacokinetics · 8
Hyperforin → Biological, Cmax, In, John's, Linear, Maximal, Some, St
related to Occurrence · 6
Hyperforin → CO2, Hypericum, It, Other Hypericum, The, This CO2
Legal status · 3
Hyperforin → UK: General sales list (GSL, OTC), unscheduled in most countries, with the notable exception of Ireland (Rx-only), US: OTC
related to External links · 3
Hyperforin → Media, Wikimedia Commons, Wiktionary-logo-en-v2
is a · 2
Hyperforin → phytochemical produced by some of the members of the plant genus Hypericum, unique PPAP because it consists of a C8 quaternary stereocenter which was a synthetic challenge unlike other PPAP synthetic targets
related to Biosynthesis · 2
Hyperforin → Current, It
3D model (JSmol) · 1
Hyperforin → Interactive image
ATC code · 1
Hyperforin → none

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Important terminology

st john's wort perforatum adhyperforin plant phytochemical antidepressant extract containing hypericum synthetic produced amounts extraction related effects biosynthesis research meta-analyses

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Hyperforin3D model (JSmol)Interactive image1.00infobox
HyperforinATC codenone1.00infobox
HyperforinCAS Number11079-53-11.00infobox
HyperforinChEBICHEBI:5834 Y1.00infobox
HyperforinChemSpider16736597 Y1.00infobox
HyperforinCompTox Dashboard (EPA)DTXSID908914091.00infobox
HyperforinDependence liabilityNone1.00infobox
HyperforinDrug classMonoamine reuptake inhibitor, psychic energizer1.00infobox
HyperforinDrugBankDB01892 Y1.00infobox
HyperforinECHA InfoCard100.112.5651.00infobox
HyperforinFormulaC35H52O41.00infobox
HyperforinIUPHAR/BPS27641.00infobox
HyperforinKEGGC07608 Y1.00infobox
HyperforinLegal statusUK: General sales list (GSL, OTC)1.00infobox
HyperforinLegal statusUS: OTC1.00infobox
HyperforinLegal statusunscheduled in most countries, with the notable exception of Ireland (Rx-only)1.00infobox
HyperforinMelting point79–80 °C (174–176 °F)1.00infobox
HyperforinMetabolismHepatic and CYP3A & CYP2B1.00infobox
HyperforinMolar mass536.797 g·mol−11.00infobox
HyperforinPubChem CID1147871.00infobox
HyperforinRoutes of administrationOral1.00infobox
HyperforinSolubility in water0.66 mg/mL (20 °C)1.00infobox
HyperforinUNIIRM741E34FP1.00infobox
Hyperforinis aphytochemical produced by some of the members of the plant genus Hypericum0.90text
Hyperforinis aunique PPAP because it consists of a C8 quaternary stereocenter which was a synthetic challenge unlike other PPAP synthetic targets0.90text

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