Hyperforin

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Hyperforin topic overview

The analysis highlights Pharmacodynamics, Chemistry and Pharmacokinetics as prominent areas in the source structure around Hyperforin.

Related topics: 39
Source areas: 6
Connected nodes: 45
Extracted relationships: 66
Concept neighborhoods: 15
Bridge connections: 45

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacodynamics · 14 topics

Overview · 11 topics

Biosynthesis · 4 topics

Chemistry · 4 topics

Pharmacokinetics · 4 topics

Occurrence · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
ATC code: none
CAS Number: 11079-53-1
ChEBI: CHEBI:5834 Y
ChemSpider: 16736597 Y
CompTox Dashboard (EPA): DTXSID90891409

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Phytochemical
Hypericum
Hypericum perforatum
Pharmacological Pharmacology
Meta-analyses Meta-analysis
Clinical trials Clinical trial
SSRIs Selective serotonin reuptake inhibitor
Depression Depression (mood)
Plant defense Plant defense against herbivory
Carbon dioxide
Adhyperforin

Occurrence

Hypericum calycinum
Pistils Pistil

Chemistry

Pharmacokinetics

Pharmacodynamics

Antidepressant
Anxiolytic
In vitro
Reuptake inhibitor of monoamines Monoamine reuptake inhibitor
Serotonin
Norepinephrine
Dopamine
GABA
Glutamate
IC50
Cytochrome P450
CYP3A4
CYP2C9
Pregnane X receptor PXR

Biosynthesis

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Hyperforin connects Entity context

The extracted context around Hyperforin shows recurring relationship patterns in the source. For example, Hyperforin → Bio-organic Chemistry, C3, C8, C9, Frequent, In, Moscow, PPAP, Sciences, Shemyakin Institute, The, USSR Academy Another extracted example is Hyperforin → CYP2C9, CYP3A4, GABA, IC50, In, John's, MRI, P450, St. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Chemistry · 12

Hyperforin → Bio-organic Chemistry, C3, C8, C9, Frequent, In, Moscow, PPAP, Sciences, Shemyakin Institute, The, USSR Academy

related to Pharmacodynamics · 9

Hyperforin → CYP2C9, CYP3A4, GABA, IC50, In, John's, MRI, P450, St

related to Pharmacokinetics · 8

Hyperforin → Biological, Cmax, In, John's, Linear, Maximal, Some, St

related to Occurrence · 6

Hyperforin → CO2, Hypericum, It, Other Hypericum, The, This CO2

Legal status · 3

Hyperforin → UK: General sales list (GSL, OTC), unscheduled in most countries, with the notable exception of Ireland (Rx-only), US: OTC

related to External links · 3

Hyperforin → Media, Wikimedia Commons, Wiktionary-logo-en-v2

is a · 2

Hyperforin → phytochemical produced by some of the members of the plant genus Hypericum, unique PPAP because it consists of a C8 quaternary stereocenter which was a synthetic challenge unlike other PPAP synthetic targets

related to Biosynthesis · 2

Hyperforin → Current, It

3D model (JSmol) · 1

Hyperforin → Interactive image

ATC code · 1

Hyperforin → none

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

st john's wort perforatum adhyperforin plant phytochemical antidepressant extract containing hypericum synthetic produced amounts extraction related effects biosynthesis research meta-analyses

Hyperforin relationships Subject–Predicate–Object triples

TTTA extracted 66 structured relationships around Hyperforin. Examples in this analysis include Hyperforin → 3D model (JSmol) → Interactive image and Hyperforin → ATC code → none. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Hyperforin	3D model (JSmol)	Interactive image	1.00	infobox
Hyperforin	ATC code	none	1.00	infobox
Hyperforin	CAS Number	11079-53-1	1.00	infobox
Hyperforin	ChEBI	CHEBI:5834 Y	1.00	infobox
Hyperforin	ChemSpider	16736597 Y	1.00	infobox
Hyperforin	CompTox Dashboard (EPA)	DTXSID90891409	1.00	infobox
Hyperforin	Dependence liability	None	1.00	infobox
Hyperforin	Drug class	Monoamine reuptake inhibitor, psychic energizer	1.00	infobox
Hyperforin	DrugBank	DB01892 Y	1.00	infobox
Hyperforin	ECHA InfoCard	100.112.565	1.00	infobox
Hyperforin	Formula	C35H52O4	1.00	infobox
Hyperforin	IUPHAR/BPS	2764	1.00	infobox
Hyperforin	KEGG	C07608 Y	1.00	infobox
Hyperforin	Legal status	UK: General sales list (GSL, OTC)	1.00	infobox
Hyperforin	Legal status	US: OTC	1.00	infobox
Hyperforin	Legal status	unscheduled in most countries, with the notable exception of Ireland (Rx-only)	1.00	infobox
Hyperforin	Melting point	79–80 °C (174–176 °F)	1.00	infobox
Hyperforin	Metabolism	Hepatic and CYP3A & CYP2B	1.00	infobox
Hyperforin	Molar mass	536.797 g·mol−1	1.00	infobox
Hyperforin	PubChem CID	114787	1.00	infobox
Hyperforin	Routes of administration	Oral	1.00	infobox
Hyperforin	Solubility in water	0.66 mg/mL (20 °C)	1.00	infobox
Hyperforin	UNII	RM741E34FP	1.00	infobox
Hyperforin	is a	phytochemical produced by some of the members of the plant genus Hypericum	0.90	text
Hyperforin	is a	unique PPAP because it consists of a C8 quaternary stereocenter which was a synthetic challenge unlike other PPAP synthetic targets	0.90	text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Hyperforin bring nearby vocabulary together. In this analysis, examples include Containing, Extract and St. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Hyperforin
- Containing
- Extract
- St
- Amounts
- Hypericum
- Produced
- Related
- Research
- Adhyperforin
- Perforatum
- Phytochemical
- Synthetic
hyperforin
- Containing
- Extract
- St
- Amounts
- Hypericum
- Produced
- Related
- Research
- Adhyperforin
- Perforatum
- Phytochemical
- Synthetic
hypericum perforatum
- Amounts
- Found
- Perforatum
- Phytochemical
- Related
- Containing
- Plant
- Although
- Antidepressant
- Better
- Biosynthesis
- Clinical
phytochemical
- Hypericum
- Produced
- Adhyperforin
- Perforatum
- Found
- Amounts
- Antidepressant
- Biosynthesis
- Extraction
- Mg
- Ml
- Related
antidepressant
- Effects
- Found
- May
- Amounts
- Biosynthesis
- Hypericum
- Mg
- Ml
- Related
- Research
- Reuptake
- Containing
hypericum
- Amounts
- Perforatum
- Phytochemical
- Found
- Antidepressant
- Biosynthesis
- Mg
- Ml
- Produced
- Related
- Research
- Reuptake
hypericum calycinum
- Amounts
- Perforatum
- Phytochemical
- Found
- Antidepressant
- Biosynthesis
- Mg
- Ml
- Produced
- Related
- Research
- Reuptake
adhyperforin
- Extraction
- Phytochemical
- Clinical
- Found
- Meta-analyses
- Trials
- Amounts
- Produced
- Related
- Containing
- Hyperforin
- Perforatum

Connections between topic areas Semantic bridges

For Hyperforin, one of the stronger structural bridges in this analysis connects Hyperforin with Pharmacodynamics. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Hyperforin — Pharmacodynamics · splits 31 ⟂ 15

Hyperforin — Overview · splits 34 ⟂ 12

Hyperforin — Chemistry · splits 41 ⟂ 5

Hyperforin — Pharmacokinetics · splits 41 ⟂ 5

Hyperforin — Biosynthesis · splits 41 ⟂ 5

Hyperforin — Occurrence · splits 43 ⟂ 3

Map overview Semantic statistics

Hyperforin

Nodes46

Edges45

Triples66

Avg. degree1.96

Density0.043478

Components1

Source & methodology

TTTA analyzes the structure around Hyperforin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Pharmacodynamics, Chemistry & Pharmacokinetics, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Hyperforin · EN edition · Analysis: TopicsToTalkAbout