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SOX9: Function, Clinical significance & Interactions

Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.

Language: English [EN]
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SOX9 topic overview

The analysis highlights Function, Clinical significance and Interactions as prominent areas in the source structure around SOX9.

Related topics
49
Source areas
6
Connected nodes
55
Extracted relationships
288
Concept neighborhoods
18
Bridge connections
55

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 27 topics
Clinical significance · 8 topics
Interactions · 6 topics
Role in sexual differentiation · 4 topics
Knock out models · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SOX9, CMD1, CMPD1, SRA1, SRXX2, SRXY10, SRY-box 9, SRY-box transcription factor 9
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EUW
Band
17q24.3 · 11 E2|11 77.27 cM
Bgee
ventricular zone · hair follicle · optic nerve · parotid gland · retinal pigment epithelium
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Role in sexual differentiation

Interactions

Knock out models

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SOX9 connects Entity context

The extracted context around SOX9 shows recurring relationship patterns in the source. For example, SOX9 → anterior head development, aortic valve morphogenesis, astrocyte fate commitment, beta-catenin binding, bHLH transcription factor binding, branching involved in ureteric bud morphogenesis, bronchus cartilage development, cAMP-mediated signaling, cartilage condensation, cartilage development, cell differentiation, cell fate commitment, cell fate specification, cell-cell adhesion, cellular response to BMP stimulus, cellular response to epidermal growth factor stimulus, cellular response to heparin, cellular response to interleukin-1, cellular response to mechanical stimulus, cellular response to retinoic acid Another extracted example is SOX9 → basisphenoid, buccal mucosa cell, cartilage organ, cartilage tissue, cervical loop, digit, epithelium of seminiferous tubule of testis, hair follicle, internal globus pallidus, lacrimal gland, lactiferous duct, main bronchus, optic nerve, parotid gland, pylorus, retinal pigment epithelium, second toe, sphenoid bone, toe, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

SOX9

Top relations

Gene ontology · 157
SOX9 → anterior head development, aortic valve morphogenesis, astrocyte fate commitment, beta-catenin binding, bHLH transcription factor binding, branching involved in ureteric bud morphogenesis, bronchus cartilage development, cAMP-mediated signaling, cartilage condensation, cartilage development, cell differentiation, cell fate commitment, cell fate specification, cell-cell adhesion, cellular response to BMP stimulus, cellular response to epidermal growth factor stimulus, cellular response to heparin, cellular response to interleukin-1, cellular response to mechanical stimulus, cellular response to retinoic acid
Bgee · 20
SOX9 → basisphenoid, buccal mucosa cell, cartilage organ, cartilage tissue, cervical loop, digit, epithelium of seminiferous tubule of testis, hair follicle, internal globus pallidus, lacrimal gland, lactiferous duct, main bronchus, optic nerve, parotid gland, pylorus, retinal pigment epithelium, second toe, sphenoid bone, toe, ventricular zone
RNA expression pattern · 20
SOX9 → basisphenoid, buccal mucosa cell, cartilage organ, cartilage tissue, cervical loop, digit, epithelium of seminiferous tubule of testis, hair follicle, internal globus pallidus, lacrimal gland, lactiferous duct, main bronchus, optic nerve, parotid gland, pylorus, retinal pigment epithelium, second toe, sphenoid bone, toe, ventricular zone
related to Function · 20
SOX9 → Activation, AMH, CCTTGAG, Dax1, DNA-binding, FGF9, HMG-box, In, It, Müllerian, Next, PGD2, Sertoli, Sf1, SOX-9, SRY, The, These, Wwp1, Wwp2
related to External links · 16
SOX9 → Human Transcription, Medicine, Medicine Medical Subject Headings, MeSH, Mouse Transcription, National Library, Overview, P48436, PDB, PDBe-KB, Q04887, SOX-9, This, UCSC Genome Browser, UniProt, United States National Library
related to Role in sexual differentiation · 10
SOX9 → DAX1, If FGF9, Mutation, Mutations, Sertoli, SRY, The, X-chromosome, XX, XY
related to Knock out models · 7
SOX9 → CD, CSPG, CSPGs, Loss, NOGO, There, These Sox9
related to Interactions · 5
SOX9 → MAF, MED12, MLL3, MLL4, SWI/SNF
related to Clinical significance · 4
SOX9 → Deletions, Mb, Mutations, Pierre Robin Sequence
related to SOX9 localization and dynamics · 3
SOX9 → DNA, Its, Studies

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene sox-9 transcription factor sry human development cells bp testis male protein chr band differentiation chromosome also sertoli fgf9 17

SOX9 relationships Subject–Predicate–Object triples

TTTA extracted 288 structured relationships around SOX9. Examples in this analysis include SOX9 → Aliases → SOX9, CMD1, CMPD1, SRA1, SRXX2, SRXY10, SRY-box 9, SRY-box transcription factor 9 and SOX9 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EUW. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SOX9AliasesSOX9, CMD1, CMPD1, SRA1, SRXX2, SRXY10, SRY-box 9, SRY-box transcription factor 91.00infobox
SOX9Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EUW1.00infobox
SOX9Band17q24.31.00infobox
SOX9Band11 E2|11 77.27 cM1.00infobox
SOX9Bgeeventricular zone1.00infobox
SOX9Bgeehair follicle1.00infobox
SOX9Bgeeoptic nerve1.00infobox
SOX9Bgeeparotid gland1.00infobox
SOX9Bgeeretinal pigment epithelium1.00infobox
SOX9Bgeeinternal globus pallidus1.00infobox
SOX9Bgeelactiferous duct1.00infobox
SOX9Bgeebuccal mucosa cell1.00infobox
SOX9Bgeecartilage tissue1.00infobox
SOX9Bgeepylorus1.00infobox
SOX9Bgeedigit1.00infobox
SOX9Bgeecartilage organ1.00infobox
SOX9Bgeesphenoid bone1.00infobox
SOX9Bgeetoe1.00infobox
SOX9Bgeebasisphenoid1.00infobox
SOX9Bgeelacrimal gland1.00infobox
SOX9Bgeemain bronchus1.00infobox
SOX9Bgeesecond toe1.00infobox
SOX9Bgeeepithelium of seminiferous tubule of testis1.00infobox
SOX9Bgeecervical loop1.00infobox
SOX9BioGPSMore reference expression data1.00infobox
SOX9Chr.Chromosome 17 (human)1.00infobox
SOX9Chr.Chromosome 11 (mouse)1.00infobox
SOX9DatabasesNCBI: entry; OMA: entry1.00infobox
SOX9End72,126,416 bp1.00infobox
SOX9End112,678,586 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SOX9 bring nearby vocabulary together. In this analysis, examples include Gene, Sry and Transcription. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • SOX9
    • Gene
    • Sry
    • Transcription
    • Testis
    • Sex
    • Differentiation
    • Human
    • Determination
    • Gonads
    • Fgf9
    • Formation
    • Also
  • sox9
    • Gene
    • Sry
    • Transcription
    • Testis
    • Sex
    • Differentiation
    • Human
    • Determination
    • Gonads
    • Fgf9
    • Formation
    • Also
  • protein
    • Expression
    • Function
    • Gene
    • Sox-9
    • Sox9
    • Human
    • Activity
    • Mouse
    • Mutations
    • Transcription
    • Uniprot
    • Band
  • gene
    • Transcription
    • Location
    • Human
    • Sox9
    • Chromosome
    • Function
    • Bp
    • Chr
    • Differentiation
    • Protein
    • Testis
    • Cells
  • steroidogenic factor 1
    • Transcription
    • Gene
    • Available
    • Pdb
    • Sox-9
    • Uniprot
    • Chromosome
    • Differentiation
    • Sox9
    • Human
    • Sry
    • Activity
  • sertoli cells
    • Sertoli
    • Male
    • Formation
    • Testis
    • Development
    • Sox-9
    • Differentiation
    • Female
    • Fgf9
    • Expression
    • Gene
    • Uniprot
  • testis determining factor
    • Transcription
    • Sertoli
    • Gene
    • Sry
    • Gonads
    • Sex
    • Available
    • Pdb
    • Sox-9
    • Uniprot
    • Chromosome
    • Differentiation
  • y chromosome
    • Bp
    • Band
    • Location
    • Human
    • Activity
    • Function
    • Mouse
    • Gene
    • Differentiation
    • Factor
    • Transcription
    • Testis

Connections between topic areas Semantic bridges

For SOX9, one of the stronger structural bridges in this analysis connects SOX9 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SOX9Function · splits 28 ⟂ 28
SOX9Clinical significance · splits 47 ⟂ 9
SOX9Interactions · splits 49 ⟂ 7
SOX9Role in sexual differentiation · splits 51 ⟂ 5
SOX9Overview · splits 53 ⟂ 3
SOX9Knock out models · splits 53 ⟂ 3

Map overview Semantic statistics

SOX9

Nodes56
Edges55
Triples288
Avg. degree1.96
Density0.035714
Components1

Source & methodology

TTTA analyzes the structure around SOX9 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SOX9 · EN edition · Analysis: TopicsToTalkAbout

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