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TBX3: Structure and function, Transcript splicing & Role in development

T-box transcription factor TBX3 is a protein that in humans is encoded by the TBX3 gene.

Language: English [EN]
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TBX3 topic overview

The analysis highlights Structure and function, Transcript splicing and Role in development as prominent areas in the source structure around TBX3.

Related topics
26
Source areas
5
Connected nodes
31
Extracted relationships
189
Concept neighborhoods
14
Bridge connections
31

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure and function · 13 topics
Overview · 8 topics
Transcript splicing · 3 topics
Role in development · 1 topics
Role in stem cells · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TBX3, TBX3-ISO, UMS, XHL, T-box 3, T-box transcription factor 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H6F
Band
12q24.21 · 5 F|5 60.34 cM
Bgee
right adrenal cortex · left adrenal cortex · urethra · stromal cell of endometrium · seminal vesicula
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 5 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Transcript splicing

Structure and function

Role in development

Role in stem cells

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TBX3 connects Entity context

The extracted context around TBX3 shows recurring relationship patterns in the source. For example, TBX3 → animal organ morphogenesis, anterior/posterior axis specification, embryo, atrioventricular bundle cell differentiation, blood vessel development, branching involved in mammary gland duct morphogenesis, cardiac muscle cell differentiation, cardiac muscle cell fate commitment, cellular senescence, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, embryonic digit morphogenesis, embryonic forelimb morphogenesis, embryonic heart tube development, embryonic hindlimb morphogenesis, female genitalia development, follicle-stimulating hormone secretion, forelimb morphogenesis, heart looping Another extracted example is TBX3 → A-CDK2, ACACCT AGGTGTGAAATT, AKT3, DBD, DNA, DNA-binding, E-cadherin, Eomes, Furthermore, G/C, Gata6, Indeed, MAP, PTEN, R1, R2, S720, Sox17, SP190, SP354. Use these groups to spot repeated connection types before inspecting the individual relationships.

TBX3

Top relations

Gene ontology · 54
TBX3 → animal organ morphogenesis, anterior/posterior axis specification, embryo, atrioventricular bundle cell differentiation, blood vessel development, branching involved in mammary gland duct morphogenesis, cardiac muscle cell differentiation, cardiac muscle cell fate commitment, cellular senescence, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, embryonic digit morphogenesis, embryonic forelimb morphogenesis, embryonic heart tube development, embryonic hindlimb morphogenesis, female genitalia development, follicle-stimulating hormone secretion, forelimb morphogenesis, heart looping
related to Structure and function · 29
TBX3 → A-CDK2, ACACCT AGGTGTGAAATT, AKT3, DBD, DNA, DNA-binding, E-cadherin, Eomes, Furthermore, G/C, Gata6, Indeed, MAP, PTEN, R1, R2, S720, Sox17, SP190, SP354
Bgee · 19
TBX3 → adrenal gland, coelomic epithelium, genital tubercle, left adrenal cortex, left lobe of thyroid gland, lobe of prostate, lumbar spinal ganglion, medullary collecting duct, pelvic ganglion, placenta, prostate, right adrenal cortex, right lobe of thyroid gland, right lung, seminal vesicula, stromal cell of endometrium, transitional epithelium of ureter, transitional epithelium of urinary bladder, urethra
RNA expression pattern · 19
TBX3 → adrenal gland, coelomic epithelium, genital tubercle, left adrenal cortex, left lobe of thyroid gland, lobe of prostate, lumbar spinal ganglion, medullary collecting duct, pelvic ganglion, placenta, prostate, right adrenal cortex, right lobe of thyroid gland, right lung, seminal vesicula, stromal cell of endometrium, transitional epithelium of ureter, transitional epithelium of urinary bladder, urethra
related to Role in stem cells · 13
TBX3 → Adult, C-MYC, Embryonic, ESC-like, ESCs, Firstly, In, Induced, KLF4, LIN-28A, Nanog, OCT4, SOX2
related to External links · 9
TBX3 → Medicine Medical Subject Headings, MeSH, National Library, O15119, Overview, PDB, PDBe-KB, T-box, UniProt
related to Clinical significance · 8
TBX3 → DNA, In, Missense, RD1, Several UMS, T-domain, These, UMS
related to Role in development · 5
TBX3 → BCL9, During, E16, These, Wnt
is a · 3
TBX3 → important factor that, member of the Tbx2 subfamily which includes Tbx2, protein that in humans is encoded by the TBX3 gene.T-box 3
related to Transcript splicing · 3
TBX3 → Alternative, T-box DNA, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein t-box human transcription mouse function cells cell bp binding chromosome stem cancer factor 12 embryonic chr band development

TBX3 relationships Subject–Predicate–Object triples

TTTA extracted 189 structured relationships around TBX3. Examples in this analysis include TBX3 → Aliases → TBX3, TBX3-ISO, UMS, XHL, T-box 3, T-box transcription factor 3 and TBX3 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H6F. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TBX3AliasesTBX3, TBX3-ISO, UMS, XHL, T-box 3, T-box transcription factor 31.00infobox
TBX3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H6F1.00infobox
TBX3Band12q24.211.00infobox
TBX3Band5 F|5 60.34 cM1.00infobox
TBX3Bgeeright adrenal cortex1.00infobox
TBX3Bgeeleft adrenal cortex1.00infobox
TBX3Bgeeurethra1.00infobox
TBX3Bgeestromal cell of endometrium1.00infobox
TBX3Bgeeseminal vesicula1.00infobox
TBX3Bgeeprostate1.00infobox
TBX3Bgeeright lobe of thyroid gland1.00infobox
TBX3Bgeeright lung1.00infobox
TBX3Bgeeleft lobe of thyroid gland1.00infobox
TBX3Bgeeplacenta1.00infobox
TBX3Bgeegenital tubercle1.00infobox
TBX3Bgeemedullary collecting duct1.00infobox
TBX3Bgeetransitional epithelium of ureter1.00infobox
TBX3Bgeelobe of prostate1.00infobox
TBX3Bgeeadrenal gland1.00infobox
TBX3Bgeetransitional epithelium of urinary bladder1.00infobox
TBX3Bgeepelvic ganglion1.00infobox
TBX3Bgeelumbar spinal ganglion1.00infobox
TBX3Bgeecoelomic epithelium1.00infobox
TBX3BioGPSMore reference expression data1.00infobox
TBX3Chr.Chromosome 12 (human)1.00infobox
TBX3Chr.Chromosome 5 (mouse)1.00infobox
TBX3DatabasesNCBI: entry; OMA: entry1.00infobox
TBX3End114,684,175 bp1.00infobox
TBX3End119,822,789 bp1.00infobox
TBX3EnsemblENSG000001351111.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TBX3 bring nearby vocabulary together. In this analysis, examples include Function, Cancer and Transcription. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TBX3
    • Function
    • Cancer
    • Transcription
    • Mammary
    • Also
    • Binding
    • Mouse
    • May
    • Splicing
    • Genes
    • Heart
    • Human
  • tbx3
    • Function
    • Cancer
    • Transcription
    • Mammary
    • Also
    • Binding
    • Mouse
    • May
    • Splicing
    • Genes
    • Heart
    • Human
  • protein
    • Human
    • Function
    • Tbx3
    • Gene
    • Regulation
    • Chromosome
    • Embryonic
    • Transcription
    • Location
    • Band
    • Expressed
    • Humans
  • gene
    • Chromosome
    • Human
    • Location
    • Mouse
    • T-box
    • Transcription
    • Bp
    • Chr
    • Protein
    • Band
    • Humans
    • Ums
  • t-box
    • Transcription
    • Factor
    • Dna
    • Gene
    • Humans
    • Splicing
    • Also
    • Binding
    • Function
    • Tbx3
    • Location
    • Tbx2
  • chromosome
    • Human
    • Bp
    • Chr
    • Location
    • Band
    • Gene
    • Splicing
    • Development
    • Factor
    • Stem
    • Mouse
    • Transcription
  • mitogen-activated protein
    • Human
    • Function
    • Tbx3
    • Gene
    • Regulation
    • Chromosome
    • Embryonic
    • Transcription
    • Location
    • Band
    • Expressed
    • Humans
  • embryonic stem cells
    • Cell
    • Stem
    • Heart
    • Mammary
    • Embryonic
    • Expressed
    • Structures
    • System
    • Development
    • Factor
    • Mouse
    • Transcription

Connections between topic areas Semantic bridges

For TBX3, one of the stronger structural bridges in this analysis connects TBX3 with Structure and function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TBX3Structure and function · splits 18 ⟂ 14
TBX3Overview · splits 23 ⟂ 9
TBX3Transcript splicing · splits 28 ⟂ 4

Map overview Semantic statistics

TBX3

Nodes32
Edges31
Triples189
Avg. degree1.94
Density0.0625
Components1

Source & methodology

TTTA analyzes the structure around TBX3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure and function, Transcript splicing & Role in development, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TBX3 · EN edition · Analysis: TopicsToTalkAbout

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