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TBX2

T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Tbx2 and Tbx3 are the only T-box transcription factors that act as transcriptional repressors rather than…

Regions, Role in tumorigenesis & Role in development

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Role in tumorigenesis

5 related topics

Role in development

4 related topics

Associated congenital defects

4 related topics

Cancer treatment target

2 related topics

Key facts & relationships

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Aliases
TBX2, T-box 2, VETD, T-box transcription factor 2
Band
17q23.2 · 11 C|11 51.34 cM
Bgee
right lung · right coronary artery · upper lobe of left lung · right uterine tube · left coronary artery
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Role in development

Associated congenital defects

Role in tumorigenesis

Cancer treatment target

Advanced semantic analysis

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Map overview Semantic statistics

TBX2

Nodes28
Edges27
Triples139
Avg. degree1.93
Density0.071429
Components1

How this topic connects Entity context

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TBX2

Top relations

Gene ontology · 37
TBX2 → aorta morphogenesis, atrioventricular canal development, cardiac muscle tissue development, cellular senescence, developmental growth involved in morphogenesis, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, embryonic camera-type eye morphogenesis, embryonic digit morphogenesis, embryonic heart tube development, endocardial cushion morphogenesis, heart looping, heart morphogenesis, mammary placode formation, multicellular organism development, muscle cell fate determination, negative regulation of cardiac chamber formation, negative regulation of heart looping
Bgee · 19
TBX2 → apex of heart, atrioventricular canal, caput epididymis, Gonadal ridge, left coronary artery, left lung lobe, lumbar spinal ganglion, maxillary prominence, medullary collecting duct, periodontal fiber, right coronary artery, right lung, right uterine tube, seminal vesicula, tibial arteries, transitional epithelium of ureter, transitional epithelium of urinary bladder, upper lobe of left lung, vestibular membrane of cochlear duct
RNA expression pattern · 19
TBX2 → apex of heart, atrioventricular canal, caput epididymis, Gonadal ridge, left coronary artery, left lung lobe, lumbar spinal ganglion, maxillary prominence, medullary collecting duct, periodontal fiber, right coronary artery, right lung, right uterine tube, seminal vesicula, tibial arteries, transitional epithelium of ureter, transitional epithelium of urinary bladder, upper lobe of left lung, vestibular membrane of cochlear duct
has treatment · 11
TBX2 → An, Because, Because Tbx2, Further, Much, Scientists, SFRP-2, Tbx3, Understanding, WNT, WNT3A
related to Role in development · 10
TBX2 → BMP, During, FGF, In, It, Tbx, Tbx-2, The, This, Wnt
related to Abnormalities of the digits · 5
TBX2 → During, FGF4, Opposite, Shh, Shh/FGF4
related to Role in tumorigenesis · 5
TBX2 → Currently, It, MDM2/p35/p21CIP1 Pathway, Several, When
related to Ventricular septal defects · 4
TBX2 → Contrary, For, Of, This
related to Associated congenital defects · 3
TBX2 → It, Mutations, Some
related to External links · 3
TBX2 → Medicine Medical Subject Headings, MeSH, National Library

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Important terminology

development gene signaling atrioventricular expression human role t-box bp heart canal proliferation fgf factor transcription chromosome cancer mouse chr band

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TBX2AliasesTBX2, T-box 2, VETD, T-box transcription factor 21.00infobox
TBX2Band17q23.21.00infobox
TBX2Band11 C|11 51.34 cM1.00infobox
TBX2Bgeeright lung1.00infobox
TBX2Bgeeright coronary artery1.00infobox
TBX2Bgeeupper lobe of left lung1.00infobox
TBX2Bgeeright uterine tube1.00infobox
TBX2Bgeeleft coronary artery1.00infobox
TBX2Bgeeseminal vesicula1.00infobox
TBX2Bgeetibial arteries1.00infobox
TBX2Bgeeapex of heart1.00infobox
TBX2Bgeeperiodontal fiber1.00infobox
TBX2Bgeecaput epididymis1.00infobox
TBX2Bgeetransitional epithelium of ureter1.00infobox
TBX2Bgeelumbar spinal ganglion1.00infobox
TBX2Bgeeleft lung lobe1.00infobox
TBX2Bgeetransitional epithelium of urinary bladder1.00infobox
TBX2Bgeeatrioventricular canal1.00infobox
TBX2Bgeemaxillary prominence1.00infobox
TBX2Bgeevestibular membrane of cochlear duct1.00infobox
TBX2BgeeGonadal ridge1.00infobox
TBX2Bgeemedullary collecting duct1.00infobox
TBX2BioGPSMore reference expression data1.00infobox
TBX2Chr.Chromosome 17 (human)1.00infobox
TBX2Chr.Chromosome 11 (mouse)1.00infobox
TBX2DatabasesNCBI: entry; OMA: entry1.00infobox
TBX2End61,409,466 bp1.00infobox
TBX2End85,732,774 bp1.00infobox
TBX2EnsemblENSG000001210681.00infobox
TBX2Entrez69091.00infobox

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