Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

TBX2: Regions, Role in tumorigenesis & Role in development

T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Tbx2 and Tbx3 are the only T-box transcription factors that act as transcriptional repressors rather than…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

TBX2 topic overview

The analysis highlights Regions, Role in tumorigenesis and Role in development as prominent areas in the source structure around TBX2.

Related topics
22
Source areas
5
Connected nodes
27
Extracted relationships
139
Concept neighborhoods
14
Bridge connections
27

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 7 topics
Role in tumorigenesis · 5 topics
Associated congenital defects · 4 topics
Role in development · 4 topics
Cancer treatment target · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TBX2, T-box 2, VETD, T-box transcription factor 2
Band
17q23.2 · 11 C|11 51.34 cM
Bgee
right lung · right coronary artery · upper lobe of left lung · right uterine tube · left coronary artery
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Role in development

Associated congenital defects

Role in tumorigenesis

Cancer treatment target

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TBX2 connects Entity context

The extracted context around TBX2 shows recurring relationship patterns in the source. For example, TBX2 → aorta morphogenesis, atrioventricular canal development, cardiac muscle tissue development, cellular senescence, developmental growth involved in morphogenesis, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, embryonic camera-type eye morphogenesis, embryonic digit morphogenesis, embryonic heart tube development, endocardial cushion morphogenesis, heart looping, heart morphogenesis, mammary placode formation, multicellular organism development, muscle cell fate determination, negative regulation of cardiac chamber formation, negative regulation of heart looping Another extracted example is TBX2 → apex of heart, atrioventricular canal, caput epididymis, Gonadal ridge, left coronary artery, left lung lobe, lumbar spinal ganglion, maxillary prominence, medullary collecting duct, periodontal fiber, right coronary artery, right lung, right uterine tube, seminal vesicula, tibial arteries, transitional epithelium of ureter, transitional epithelium of urinary bladder, upper lobe of left lung, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.

TBX2

Top relations

Gene ontology · 37
TBX2 → aorta morphogenesis, atrioventricular canal development, cardiac muscle tissue development, cellular senescence, developmental growth involved in morphogenesis, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, embryonic camera-type eye morphogenesis, embryonic digit morphogenesis, embryonic heart tube development, endocardial cushion morphogenesis, heart looping, heart morphogenesis, mammary placode formation, multicellular organism development, muscle cell fate determination, negative regulation of cardiac chamber formation, negative regulation of heart looping
Bgee · 19
TBX2 → apex of heart, atrioventricular canal, caput epididymis, Gonadal ridge, left coronary artery, left lung lobe, lumbar spinal ganglion, maxillary prominence, medullary collecting duct, periodontal fiber, right coronary artery, right lung, right uterine tube, seminal vesicula, tibial arteries, transitional epithelium of ureter, transitional epithelium of urinary bladder, upper lobe of left lung, vestibular membrane of cochlear duct
RNA expression pattern · 19
TBX2 → apex of heart, atrioventricular canal, caput epididymis, Gonadal ridge, left coronary artery, left lung lobe, lumbar spinal ganglion, maxillary prominence, medullary collecting duct, periodontal fiber, right coronary artery, right lung, right uterine tube, seminal vesicula, tibial arteries, transitional epithelium of ureter, transitional epithelium of urinary bladder, upper lobe of left lung, vestibular membrane of cochlear duct
has treatment · 11
TBX2 → An, Because, Because Tbx2, Further, Much, Scientists, SFRP-2, Tbx3, Understanding, WNT, WNT3A
related to Role in development · 10
TBX2 → BMP, During, FGF, In, It, Tbx, Tbx-2, The, This, Wnt
related to Abnormalities of the digits · 5
TBX2 → During, FGF4, Opposite, Shh, Shh/FGF4
related to Role in tumorigenesis · 5
TBX2 → Currently, It, MDM2/p35/p21CIP1 Pathway, Several, When
related to Ventricular septal defects · 4
TBX2 → Contrary, For, Of, This
related to Associated congenital defects · 3
TBX2 → It, Mutations, Some
related to External links · 3
TBX2 → Medicine Medical Subject Headings, MeSH, National Library

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

development gene signaling atrioventricular expression human role t-box bp heart canal proliferation fgf factor transcription chromosome cancer mouse chr band

TBX2 relationships Subject–Predicate–Object triples

TTTA extracted 139 structured relationships around TBX2. Examples in this analysis include TBX2 → Aliases → TBX2, T-box 2, VETD, T-box transcription factor 2 and TBX2 → Band → 17q23.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TBX2AliasesTBX2, T-box 2, VETD, T-box transcription factor 21.00infobox
TBX2Band17q23.21.00infobox
TBX2Band11 C|11 51.34 cM1.00infobox
TBX2Bgeeright lung1.00infobox
TBX2Bgeeright coronary artery1.00infobox
TBX2Bgeeupper lobe of left lung1.00infobox
TBX2Bgeeright uterine tube1.00infobox
TBX2Bgeeleft coronary artery1.00infobox
TBX2Bgeeseminal vesicula1.00infobox
TBX2Bgeetibial arteries1.00infobox
TBX2Bgeeapex of heart1.00infobox
TBX2Bgeeperiodontal fiber1.00infobox
TBX2Bgeecaput epididymis1.00infobox
TBX2Bgeetransitional epithelium of ureter1.00infobox
TBX2Bgeelumbar spinal ganglion1.00infobox
TBX2Bgeeleft lung lobe1.00infobox
TBX2Bgeetransitional epithelium of urinary bladder1.00infobox
TBX2Bgeeatrioventricular canal1.00infobox
TBX2Bgeemaxillary prominence1.00infobox
TBX2Bgeevestibular membrane of cochlear duct1.00infobox
TBX2BgeeGonadal ridge1.00infobox
TBX2Bgeemedullary collecting duct1.00infobox
TBX2BioGPSMore reference expression data1.00infobox
TBX2Chr.Chromosome 17 (human)1.00infobox
TBX2Chr.Chromosome 11 (mouse)1.00infobox
TBX2DatabasesNCBI: entry; OMA: entry1.00infobox
TBX2End61,409,466 bp1.00infobox
TBX2End85,732,774 bp1.00infobox
TBX2EnsemblENSG000001210681.00infobox
TBX2Entrez69091.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TBX2 bring nearby vocabulary together. In this analysis, examples include Development, Signaling and Expression. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TBX2
    • Development
    • Signaling
    • Expression
    • Atrioventricular
    • Cancer
    • Heart
    • Region
    • Cells
    • Fgf
    • Proliferation
    • Role
    • Bmp
  • tbx2
    • Development
    • Signaling
    • Expression
    • Atrioventricular
    • Cancer
    • Heart
    • Region
    • Cells
    • Fgf
    • Proliferation
    • Role
    • Bmp
  • transcription factor
    • Transcription
    • Chromosome
    • T-box
    • Canal
    • Bp
    • Chr
    • Tumorigenesis
    • Atrioventricular
    • Gene
    • Human
    • Band
    • Cell
  • gene
    • Expression
    • Chromosome
    • Atrioventricular
    • Canal
    • Tbx2
    • Transcription
    • Bp
    • Chr
    • Region
    • T-box
    • Mouse
    • Human
  • role in development
    • Signaling
    • Tbx2
    • Fgf
    • Cancer
    • Heart
    • Bmp
    • Limb
    • Tumorigenesis
    • Wnt
    • Proliferation
    • Expression
    • Fetal
  • role in tumorigenesis
    • Transcription
    • Cancer
    • T-box
    • Pathways
    • Role
    • Tumorigenesis
    • Wnt
    • Tbx3
    • Bp
    • Chr
    • Chromosome
    • Defects
  • cancer treatment target
    • Role
    • Cell
    • Shown
    • Tumorigenesis
    • Cells
    • Human
    • Tbx2
    • Transcription
    • Bp
    • Chr
    • Chromosome
    • Defects
  • associated congenital defects
    • Heart
    • Transcription
    • Bp
    • Chr
    • Factor
    • Region
    • Shown
    • T-box
    • Tumorigenesis
    • Various
    • Gene
    • Knockout

Connections between topic areas Semantic bridges

For TBX2, one of the stronger structural bridges in this analysis connects TBX2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TBX2Overview · splits 20 ⟂ 8
TBX2Role in tumorigenesis · splits 22 ⟂ 6
TBX2Role in development · splits 23 ⟂ 5
TBX2Associated congenital defects · splits 23 ⟂ 5
TBX2Cancer treatment target · splits 25 ⟂ 3

Map overview Semantic statistics

TBX2

Nodes28
Edges27
Triples139
Avg. degree1.93
Density0.071429
Components1

Source & methodology

TTTA analyzes the structure around TBX2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Role in tumorigenesis & Role in development, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TBX2 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.