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TBX5 (gene): Function, Interactions & Clinical significance

T-box transcription factor TBX5, (T-box protein 5) is a protein that in humans is encoded by the TBX5 gene. Abnormalities in the TBX5 gene can result in altered limb development, Holt-Oram syndrome, Tetra-amelia syndrome, and cardiac and skeletal problems.

Language: English [EN]
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TBX5 (gene) topic overview

The analysis highlights Function, Interactions and Clinical significance as prominent areas in the source structure around TBX5 (gene).

Related topics
24
Source areas
4
Connected nodes
28
Extracted relationships
118
Concept neighborhoods
15
Bridge connections
28

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 11 topics
Overview · 9 topics
Interactions · 3 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TBX5, HOS, T-box 5, T-box transcription factor 5
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2X6U, 2X6V, 4S0H, 5BQD
Band
12q24.21 · 5 F|5 60.42 cM
Bgee
tendon of biceps brachii · cardiac muscle tissue of right atrium · buccal mucosa cell · right auricle of heart · lower lobe of lung
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 5 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TBX5 (gene) connects Entity context

The extracted context around TBX5 (gene) shows recurring relationship patterns in the source. For example, TBX5 (gene) → atrial septum development, atrial septum morphogenesis, atrioventricular valve morphogenesis, bundle of His development, cardiac left ventricle formation, cardiac muscle cell differentiation, cell migration involved in coronary vasculogenesis, cell-cell signaling, cytoplasm, development of the heart, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic forelimb morphogenesis, embryonic limb morphogenesis, endocardial cushion development, forelimb morphogenesis, lung development, morphogenesis of an epithelium Another extracted example is TBX5 (gene) → buccal mucosa cell, Cardiac muscle tissue of myocardium, cardiac muscle tissue of right atrium, genital tubercle, human penis, inferior vena cava, interatrial septum, lower lobe of lung, myocardium of left ventricle, oocyte, primordial ventricle, right auricle of heart, right lung, right ventricle, sinus venosus, superior vena cava, tendon of biceps brachii, urethra, vena cava, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

TBX5 (gene)

Top relations

Gene ontology · 46
TBX5 (gene) → atrial septum development, atrial septum morphogenesis, atrioventricular valve morphogenesis, bundle of His development, cardiac left ventricle formation, cardiac muscle cell differentiation, cell migration involved in coronary vasculogenesis, cell-cell signaling, cytoplasm, development of the heart, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic forelimb morphogenesis, embryonic limb morphogenesis, endocardial cushion development, forelimb morphogenesis, lung development, morphogenesis of an epithelium
Bgee · 20
TBX5 (gene) → buccal mucosa cell, Cardiac muscle tissue of myocardium, cardiac muscle tissue of right atrium, genital tubercle, human penis, inferior vena cava, interatrial septum, lower lobe of lung, myocardium of left ventricle, oocyte, primordial ventricle, right auricle of heart, right lung, right ventricle, sinus venosus, superior vena cava, tendon of biceps brachii, urethra, vena cava, visceral pleura
RNA expression pattern · 20
TBX5 (gene) → buccal mucosa cell, Cardiac muscle tissue of myocardium, cardiac muscle tissue of right atrium, genital tubercle, human penis, inferior vena cava, interatrial septum, lower lobe of lung, myocardium of left ventricle, oocyte, primordial ventricle, right auricle of heart, right lung, right ventricle, sinus venosus, superior vena cava, tendon of biceps brachii, urethra, vena cava, visceral pleura
Band · 2
TBX5 (gene) → 12q24.21, 5 F|5 60.42 cM
Chr. · 2
TBX5 (gene) → Chromosome 12 (human), Chromosome 5 (mouse)
End · 2
TBX5 (gene) → 114,408,442 bp, 120,023,284 bp
related to Interactions · 2
TBX5 (gene) → GATA4, TBX5
Aliases · 1
TBX5 (gene) → TBX5, HOS, T-box 5, T-box transcription factor 5
Available structures · 1
TBX5 (gene) → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2X6U, 2X6V, 4S0H, 5BQD
BioGPS · 1
TBX5 (gene) → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tbx5 gene development t-box human transcription protein factor heart syndrome chromosome 12 forelimb bp limb involved cardiac chr band genes

TBX5 (gene) relationships Subject–Predicate–Object triples

TTTA extracted 118 structured relationships around TBX5 (gene). Examples in this analysis include TBX5 (gene) → Aliases → TBX5, HOS, T-box 5, T-box transcription factor 5 and TBX5 (gene) → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2X6U, 2X6V, 4S0H, 5BQD. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TBX5 (gene)AliasesTBX5, HOS, T-box 5, T-box transcription factor 51.00infobox
TBX5 (gene)Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2X6U, 2X6V, 4S0H, 5BQD1.00infobox
TBX5 (gene)Band12q24.211.00infobox
TBX5 (gene)Band5 F|5 60.42 cM1.00infobox
TBX5 (gene)Bgeetendon of biceps brachii1.00infobox
TBX5 (gene)Bgeecardiac muscle tissue of right atrium1.00infobox
TBX5 (gene)Bgeebuccal mucosa cell1.00infobox
TBX5 (gene)Bgeeright auricle of heart1.00infobox
TBX5 (gene)Bgeelower lobe of lung1.00infobox
TBX5 (gene)Bgeeright ventricle1.00infobox
TBX5 (gene)Bgeemyocardium of left ventricle1.00infobox
TBX5 (gene)Bgeevisceral pleura1.00infobox
TBX5 (gene)Bgeeright lung1.00infobox
TBX5 (gene)Bgeeoocyte1.00infobox
TBX5 (gene)BgeeCardiac muscle tissue of myocardium1.00infobox
TBX5 (gene)Bgeevena cava1.00infobox
TBX5 (gene)Bgeesinus venosus1.00infobox
TBX5 (gene)Bgeegenital tubercle1.00infobox
TBX5 (gene)Bgeeprimordial ventricle1.00infobox
TBX5 (gene)Bgeehuman penis1.00infobox
TBX5 (gene)Bgeeinferior vena cava1.00infobox
TBX5 (gene)Bgeeurethra1.00infobox
TBX5 (gene)Bgeesuperior vena cava1.00infobox
TBX5 (gene)Bgeeinteratrial septum1.00infobox
TBX5 (gene)BioGPSMore reference expression data1.00infobox
TBX5 (gene)Chr.Chromosome 12 (human)1.00infobox
TBX5 (gene)Chr.Chromosome 5 (mouse)1.00infobox
TBX5 (gene)DatabasesNCBI: entry; OMA: entry1.00infobox
TBX5 (gene)End114,408,442 bp1.00infobox
TBX5 (gene)End120,023,284 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TBX5 (gene) bring nearby vocabulary together. In this analysis, examples include Development, T-box and Tbx5. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TBX5 (gene)
    • Development
    • T-box
    • Tbx5
    • Limb
    • Transcription
    • Syndrome
    • Heart
    • Family
    • Embryonic
    • Holt-oram
    • Bp
    • Forelimb
  • tbx5 (gene)
    • Development
    • T-box
    • Tbx5
    • Chromosome
    • Human
    • Transcription
    • Limb
    • Syndrome
    • Heart
    • Family
    • Location
    • Embryonic
  • protein
    • T-box
    • Transcription
    • Limb
    • Called
    • Expression
    • Bud
    • Tbx5
    • Forelimb
    • Human
    • Gene
    • Mouse
    • Cell
  • gene
    • T-box
    • Tbx5
    • Development
    • Chromosome
    • Human
    • Transcription
    • Syndrome
    • Family
    • Location
    • Embryonic
    • Bp
    • Chr
  • t-box
    • Transcription
    • Factor
    • Protein
    • Family
    • Gene
    • Genes
    • Chromosome
    • Human
    • Limb
    • Tbx5
    • Member
    • Called
  • chromosome 12
    • Human
    • Bp
    • Chr
    • Location
    • Band
    • Mouse
    • Function
    • Embryonic
    • T-box
    • Gene
    • Factor
    • Transcription
  • transcription factor
    • Factor
    • Transcription
    • T-box
    • Protein
    • Factors
    • Called
    • Function
    • Location
    • Gene
    • Embryonic
    • Bp
    • Chr
  • fibroblast growth factor
    • Transcription
    • T-box
    • Protein
    • Called
    • Function
    • Location
    • Gene
    • Embryonic
    • Bp
    • Chr
    • Chromosome
    • Tbx5

Connections between topic areas Semantic bridges

For TBX5 (gene), one of the stronger structural bridges in this analysis connects TBX5 (gene) with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TBX5 (gene)Function · splits 17 ⟂ 12
TBX5 (gene)Overview · splits 19 ⟂ 10
TBX5 (gene)Interactions · splits 25 ⟂ 4

Map overview Semantic statistics

TBX5 (gene)

Nodes29
Edges28
Triples118
Avg. degree1.93
Density0.068966
Components1

Source & methodology

TTTA analyzes the structure around TBX5 (gene) to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TBX5 (gene) · EN edition · Analysis: TopicsToTalkAbout

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