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Syndecan-4: Clinical significance, Function & Structure

Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa.

Language: English [EN]
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Syndecan-4 topic overview

The analysis highlights Clinical significance, Function and Structure as prominent areas in the source structure around Syndecan-4.

Related topics
17
Source areas
5
Connected nodes
22
Extracted relationships
116
Concept neighborhoods
9
Bridge connections
22

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 7 topics
Function · 4 topics
Structure · 3 topics
Overview · 2 topics
Gene · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SDC4, SYND4, syndecan 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EJP, 1EJQ, 1OBY, 1YBO
Band
20q13.12 · 2 H3|2 85.16 cM
Bgee
olfactory zone of nasal mucosa · nasal epithelium · cartilage tissue · beta cell · epithelium of bronchus
BioGPS
More reference expression data
Chr.
Chromosome 20 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Gene

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Syndecan-4 connects Entity context

The extracted context around Syndecan-4 shows recurring relationship patterns in the source. For example, Syndecan-4 → cell migration, cell surface, costamere, extracellular exosome, extracellular region, fibronectin binding, focal adhesion, glycosaminoglycan biosynthetic process, glycosaminoglycan catabolic process, glycosaminoglycan metabolic process, Golgi lumen, identical protein binding, inner ear receptor cell stereocilium organization, integral component of membrane, integral component of plasma membrane, leukocyte migration, lysosomal lumen, membrane, membrane raft, negative regulation of T cell proliferation Another extracted example is Syndecan-4 → aortic valve, ascending aorta, beta cell, blastocyst, bronchial epithelial cell, cartilage tissue, ciliary body, epithelium of bronchus, external globus pallidus, gallbladder, human kidney, lacrimal gland, left lobe of liver, nasal epithelium, olfactory zone of nasal mucosa, skin of abdomen, skin of leg, superior surface of tongue, utricle, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.

Syndecan-4

Top relations

Gene ontology · 35
Syndecan-4 → cell migration, cell surface, costamere, extracellular exosome, extracellular region, fibronectin binding, focal adhesion, glycosaminoglycan biosynthetic process, glycosaminoglycan catabolic process, glycosaminoglycan metabolic process, Golgi lumen, identical protein binding, inner ear receptor cell stereocilium organization, integral component of membrane, integral component of plasma membrane, leukocyte migration, lysosomal lumen, membrane, membrane raft, negative regulation of T cell proliferation
Bgee · 20
Syndecan-4 → aortic valve, ascending aorta, beta cell, blastocyst, bronchial epithelial cell, cartilage tissue, ciliary body, epithelium of bronchus, external globus pallidus, gallbladder, human kidney, lacrimal gland, left lobe of liver, nasal epithelium, olfactory zone of nasal mucosa, skin of abdomen, skin of leg, superior surface of tongue, utricle, vestibular membrane of cochlear duct
RNA expression pattern · 20
Syndecan-4 → aortic valve, ascending aorta, beta cell, blastocyst, bronchial epithelial cell, cartilage tissue, ciliary body, epithelium of bronchus, external globus pallidus, gallbladder, human kidney, lacrimal gland, left lobe of liver, nasal epithelium, olfactory zone of nasal mucosa, skin of abdomen, skin of leg, superior surface of tongue, utricle, vestibular membrane of cochlear duct
related to External links · 5
Syndecan-4 → Overview, P31431, PDB, PDBe-KB, UniProt
related to Endometriosis · 4
Syndecan-4 → Activating, ATF2, GTPase Rac1, MMP3
related to Function · 4
Syndecan-4 → It, PIP2, PKC, The
related to Osteoarthritis · 3
Syndecan-4 → OA, See Sindecán-4, Spanish Wikipedia
Band · 2
Syndecan-4 → 2 H3|2 85.16 cM, 20q13.12
Chr. · 2
Syndecan-4 → Chromosome 2 (mouse), Chromosome 20 (human)
End · 2
Syndecan-4 → 164,285,807 bp, 45,348,424 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

syndecans 20 gene bp cell chr human band chromosome protein sdc4 signaling also growth syndecan function found external mouse receptor

Syndecan-4 relationships Subject–Predicate–Object triples

TTTA extracted 116 structured relationships around Syndecan-4. Examples in this analysis include Syndecan-4 → Aliases → SDC4, SYND4, syndecan 4 and Syndecan-4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EJP, 1EJQ, 1OBY, 1YBO. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Syndecan-4AliasesSDC4, SYND4, syndecan 41.00infobox
Syndecan-4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EJP, 1EJQ, 1OBY, 1YBO1.00infobox
Syndecan-4Band20q13.121.00infobox
Syndecan-4Band2 H3|2 85.16 cM1.00infobox
Syndecan-4Bgeeolfactory zone of nasal mucosa1.00infobox
Syndecan-4Bgeenasal epithelium1.00infobox
Syndecan-4Bgeecartilage tissue1.00infobox
Syndecan-4Bgeebeta cell1.00infobox
Syndecan-4Bgeeepithelium of bronchus1.00infobox
Syndecan-4Bgeebronchial epithelial cell1.00infobox
Syndecan-4Bgeeskin of abdomen1.00infobox
Syndecan-4Bgeeskin of leg1.00infobox
Syndecan-4Bgeeexternal globus pallidus1.00infobox
Syndecan-4Bgeehuman kidney1.00infobox
Syndecan-4Bgeevestibular membrane of cochlear duct1.00infobox
Syndecan-4Bgeegallbladder1.00infobox
Syndecan-4Bgeelacrimal gland1.00infobox
Syndecan-4Bgeeblastocyst1.00infobox
Syndecan-4Bgeeciliary body1.00infobox
Syndecan-4Bgeeutricle1.00infobox
Syndecan-4Bgeeascending aorta1.00infobox
Syndecan-4Bgeeleft lobe of liver1.00infobox
Syndecan-4Bgeesuperior surface of tongue1.00infobox
Syndecan-4Bgeeaortic valve1.00infobox
Syndecan-4BioGPSMore reference expression data1.00infobox
Syndecan-4Chr.Chromosome 20 (human)1.00infobox
Syndecan-4Chr.Chromosome 2 (mouse)1.00infobox
Syndecan-4DatabasesNCBI: entry; OMA: entry1.00infobox
Syndecan-4End45,348,424 bp1.00infobox
Syndecan-4End164,285,807 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Syndecan-4 bring nearby vocabulary together. In this analysis, examples include Also, Growth and Signaling. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • protein
    • Sdc4
    • Gene
    • Cell
    • External
    • P31431
    • Uniprot
    • Activity
    • Cytoskeleton
    • Expression
    • Fibroblast
    • Focal
    • Healing
  • gene
    • Sdc4
    • Location
    • Human
    • Bp
    • Chr
    • Chromosome
    • External
    • Healing
    • Mouse
    • Band
    • Function
    • Protein
  • cell cortex
    • Adhesion
    • Surface
    • Function
    • Syndecans
    • Cytoskeleton
    • Receptor
    • Protein
    • Also
    • Signaling
    • External
    • P31431
    • Uniprot
  • function
    • Adhesion
    • External
    • Location
    • Surface
    • Cell
    • Human
    • Sdc4
    • Bp
    • Chr
    • Chromosome
    • Gene
    • P31431
  • Syndecan-4
    • Also
    • Growth
    • Signaling
    • Syndecans
    • Activity
    • Could
    • Expression
    • Molecular
    • Domain
    • Receptor
    • P31431
    • Pdb
  • syndecan-4
    • Also
    • Growth
    • Signaling
    • Syndecans
    • Activity
    • Could
    • Expression
    • Molecular
    • Domain
    • Receptor
    • P31431
    • Pdb
  • chondroitin sulfate
    • Factors
    • Syndecans
    • Growth
    • Syndecan-4
  • heparan sulfate
    • Factors
    • Syndecans
    • Growth
    • Syndecan-4

Connections between topic areas Semantic bridges

For Syndecan-4, one of the stronger structural bridges in this analysis connects Syndecan-4 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Syndecan-4Clinical significance · splits 15 ⟂ 8
Syndecan-4Function · splits 18 ⟂ 5
Syndecan-4Structure · splits 19 ⟂ 4
Syndecan-4Overview · splits 20 ⟂ 3

Map overview Semantic statistics

Syndecan-4

Nodes23
Edges22
Triples116
Avg. degree1.91
Density0.086957
Components1

Source & methodology

TTTA analyzes the structure around Syndecan-4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Syndecan-4 · EN edition · Analysis: TopicsToTalkAbout

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