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Erlotinib

Erlotinib, sold under the brand name Tarceva among others, is a medication used to treat non-small cell lung cancer (NSCLC) and pancreatic cancer. Specifically it is used for NSCLC with mutations in the epidermal growth factor receptor (EGFR) — either an exon 19 deletion (del19) or exon 21 (L858R) substitution mutation — which has spread to other parts…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01EB02 (WHO)
Bioavailability
59%
CAS Number
183321-74-6 Y
ChEBI
CHEBI:114785 Y

Topics to explore

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Overview

Medical uses

Side effects

Interactions

Mechanism

Society and culture

Advanced semantic analysis

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Map overview Semantic statistics

Erlotinib

Nodes61
Edges60
Triples85
Avg. degree1.97
Density0.032787
Components1

How this topic connects Entity context

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Erlotinib

Top relations

related to Society and culture · 14
Erlotinib → Cipla, Delaware, Genentech, In India, In May, Indian, It, Mylan Pharmaceuticals, OSI Pharmaceutical LLC, OSI Pharmaceuticals, Roche, The, United States, US District Court
related to Lung cancer · 11
Erlotinib → BAC, Drug Administration, EGFR, FDA, Food, Genzyme, In, Overall, Patients, PFS, The
has treatment · 10
Erlotinib → Approximately, As, ATP, CML, EGFR, ERBB3, In, Over, PI3K, T790M
related to Interactions · 9
Erlotinib → Also, Compounds, CYP3A4, OATP-1B1, OATP-1B3, OATP1B1, OATP1B3, OATPs, St John's
related to Mechanism · 8
Erlotinib → ATP, EGFR, For, Iressa, It, The, These, When
Legal status · 3
Erlotinib → AU: S4 (Prescription only), UK: POM (Prescription only), US: ℞-only
related to Pancreatic cancer · 2
Erlotinib → FDA, In November
3D model (JSmol) · 1
Erlotinib → Interactive image
AHFS/Drugs.com · 1
Erlotinib → Monograph
ATC code · 1
Erlotinib → L01EB02 (WHO)

Important terminology Word statistics

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Important terminology

egfr cancer lung receptor epidermal growth factor effects patients may use side drug tyrosine kinase rash liver resistance treatment pancreatic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Erlotinib3D model (JSmol)Interactive image1.00infobox
ErlotinibAHFS/Drugs.comMonograph1.00infobox
ErlotinibATC codeL01EB02 (WHO)1.00infobox
ErlotinibBioavailability59%1.00infobox
ErlotinibCAS Number183321-74-6 Y1.00infobox
ErlotinibChEBICHEBI:114785 Y1.00infobox
ErlotinibChEMBLChEMBL553 Y1.00infobox
ErlotinibChemSpider154044 Y1.00infobox
ErlotinibCompTox Dashboard (EPA)DTXSID80464541.00infobox
ErlotinibDrugBankDB00530 Y1.00infobox
ErlotinibECHA InfoCard100.216.0201.00infobox
ErlotinibElimination half-life36.2 hrs (median)1.00infobox
ErlotinibExcretion>98% as metabolites, of which >90% via feces, 9% via urine1.00infobox
ErlotinibFormulaC22H23N3O41.00infobox
ErlotinibIUPHAR/BPS49201.00infobox
ErlotinibKEGGD07907 Y1.00infobox
ErlotinibLegal statusAU: S4 (Prescription only)1.00infobox
ErlotinibLegal statusUK: POM (Prescription only)1.00infobox
ErlotinibLegal statusUS: ℞-only1.00infobox
ErlotinibLicense dataUS DailyMed: Erlotinib1.00infobox
ErlotinibMedlinePlusa6050081.00infobox
ErlotinibMetabolismLiver (mainly CYP3A4, less CYP1A2)1.00infobox
ErlotinibMolar mass393.443 g·mol−11.00infobox
ErlotinibOther namesErlotinib hydrochloride1.00infobox
ErlotinibPregnancy categoryAU: C1.00infobox
ErlotinibProtein binding95%1.00infobox
ErlotinibPubChem CID1768701.00infobox
ErlotinibRoutes of administrationBy mouth1.00infobox
ErlotinibTrade namesTarceva1.00infobox
ErlotinibUNIIJ4T82NDH7E1.00infobox

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