Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

CD135: Clinical significance, Function & Structure

Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3 with fms standing for "feline McDonough sarcoma"), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

CD135 topic overview

The analysis highlights Clinical significance, Function and Structure as prominent areas in the source structure around CD135.

Related topics
35
Source areas
4
Connected nodes
39
Extracted relationships
163
Concept neighborhoods
20
Bridge connections
39

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 19 topics
Function · 7 topics
Overview · 7 topics
Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1
↗
Aliases
FLT3, CD135, FLK-2, FLK2, STK1, fms related tyrosine kinase 3, fms related receptor tyrosine kinase 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RJB, 3QS7, 3QS9, 4RT7, 4XUF
Band
13q12.2 · 5 86.88 cM|5 G3
Bgee
testicle · cerebellar hemisphere · monocyte · right hemisphere of cerebellum · bone marrow cell
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD135 connects Entity context

The extracted context around CD135 shows recurring relationship patterns in the source. For example, CD135 → 1-phosphatidylinositol-3-kinase activity, animal organ regeneration, ATP binding, B cell differentiation, cell differentiation, cellular response to cytokine stimulus, cellular response to glucocorticoid stimulus, common myeloid progenitor cell proliferation, cytokine receptor activity, cytokine-mediated signaling pathway, cytoplasm, cytosol, dendritic cell differentiation, endoplasmic reticulum, endoplasmic reticulum lumen, glucocorticoid receptor binding, hematopoietic progenitor cell differentiation, hemopoiesis, integral component of membrane, integral component of plasma membrane Another extracted example is CD135 → appendix, body of pancreas, bone marrow cell, cerebellar hemisphere, cochlear nuclei, facial motor nucleus, granulocyte, lymph node, medial preoptic nucleus, mesenteric lymph nodes, monocyte, motor neuron, red nucleus, Region II of hippocampus proper, Region IV of hippocampus proper, right hemisphere of cerebellum, set of nuclei of trapezoid body, spleen, superior olivary complex, testicle. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD135

Top relations

Gene ontology · 64
CD135 → 1-phosphatidylinositol-3-kinase activity, animal organ regeneration, ATP binding, B cell differentiation, cell differentiation, cellular response to cytokine stimulus, cellular response to glucocorticoid stimulus, common myeloid progenitor cell proliferation, cytokine receptor activity, cytokine-mediated signaling pathway, cytoplasm, cytosol, dendritic cell differentiation, endoplasmic reticulum, endoplasmic reticulum lumen, glucocorticoid receptor binding, hematopoietic progenitor cell differentiation, hemopoiesis, integral component of membrane, integral component of plasma membrane
Bgee · 20
CD135 → appendix, body of pancreas, bone marrow cell, cerebellar hemisphere, cochlear nuclei, facial motor nucleus, granulocyte, lymph node, medial preoptic nucleus, mesenteric lymph nodes, monocyte, motor neuron, red nucleus, Region II of hippocampus proper, Region IV of hippocampus proper, right hemisphere of cerebellum, set of nuclei of trapezoid body, spleen, superior olivary complex, testicle
RNA expression pattern · 20
CD135 → appendix, body of pancreas, bone marrow cell, cerebellar hemisphere, cochlear nuclei, facial motor nucleus, granulocyte, lymph node, medial preoptic nucleus, mesenteric lymph nodes, monocyte, motor neuron, red nucleus, Region II of hippocampus proper, Region IV of hippocampus proper, right hemisphere of cerebellum, set of nuclei of trapezoid body, spleen, superior olivary complex, testicle
related to External links · 13
CD135 → Antigen, FLT3, Human FLT3, Medicine Medical Subject Headings, MeSH, National Library, Overview, P36888, PDB, PDBe-KB, Receptor-type, UCSC Genome Browser, UniProt
related to Function · 9
CD135 → FLT3, FLT3-induced, FLT3L, III, Signaling, The, This, Two, When
related to Cell surface marker · 6
CD135 → CD, CLP, Cluster, HSC, In, MPPs
related to Role in cancer · 5
CD135 → AML, FLT3, FLT3-ITD, Internal, Mutations
Band · 2
CD135 → 13q12.2, 5 86.88 cM|5 G3
Chr. · 2
CD135 → Chromosome 13 (human), Chromosome 5 (mouse)
End · 2
CD135 → 147,337,299 bp, 28,100,592 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

flt3 kinase receptor tyrosine gene aml bp leukemia mutations human cell chr band cytokine patients activity cells hematopoietic differentiation acute

CD135 relationships Subject–Predicate–Object triples

TTTA extracted 163 structured relationships around CD135. Examples in this analysis include CD135 → 2.7.10.1 → ↗ and CD135 → Aliases → FLT3, CD135, FLK-2, FLK2, STK1, fms related tyrosine kinase 3, fms related receptor tyrosine kinase 3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD1352.7.10.1↗1.00infobox
CD135AliasesFLT3, CD135, FLK-2, FLK2, STK1, fms related tyrosine kinase 3, fms related receptor tyrosine kinase 31.00infobox
CD135Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RJB, 3QS7, 3QS9, 4RT7, 4XUF1.00infobox
CD135Band13q12.21.00infobox
CD135Band5 86.88 cM|5 G31.00infobox
CD135Bgeetesticle1.00infobox
CD135Bgeecerebellar hemisphere1.00infobox
CD135Bgeemonocyte1.00infobox
CD135Bgeeright hemisphere of cerebellum1.00infobox
CD135Bgeebone marrow cell1.00infobox
CD135Bgeelymph node1.00infobox
CD135Bgeegranulocyte1.00infobox
CD135Bgeebody of pancreas1.00infobox
CD135Bgeespleen1.00infobox
CD135Bgeeappendix1.00infobox
CD135Bgeesuperior olivary complex1.00infobox
CD135Bgeefacial motor nucleus1.00infobox
CD135Bgeered nucleus1.00infobox
CD135Bgeemesenteric lymph nodes1.00infobox
CD135Bgeeset of nuclei of trapezoid body1.00infobox
CD135Bgeecochlear nuclei1.00infobox
CD135Bgeemotor neuron1.00infobox
CD135Bgeemedial preoptic nucleus1.00infobox
CD135BgeeRegion IV of hippocampus proper1.00infobox
CD135BgeeRegion II of hippocampus proper1.00infobox
CD135BioGPSMore reference expression data1.00infobox
CD135Chr.Chromosome 13 (human)1.00infobox
CD135Chr.Chromosome 5 (mouse)1.00infobox
CD135DatabasesNCBI: entry; OMA: entry1.00infobox
CD135End28,100,592 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD135 bring nearby vocabulary together. In this analysis, examples include Tyrosine, Receptor and Differentiation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD135
    • Tyrosine
    • Receptor
    • Differentiation
    • Kinase
    • Cell
    • Cancer
    • Cluster
    • Also
    • Cytokine
    • Protein
    • Gene
    • Flt3
  • cd135
    • Tyrosine
    • Receptor
    • Differentiation
    • Kinase
    • Cell
    • Cancer
    • Cluster
    • Also
    • Cytokine
    • Protein
    • Gene
    • Flt3
  • cytokine receptor
    • Receptor
    • Tyrosine
    • Differentiation
    • Kinase
    • Flt3l
    • Cancer
    • Mouse
    • Chromosome
    • Location
    • Bp
    • Chr
    • Expressed
  • flt3 ligand
    • Aml
    • Receptor
    • Patients
    • Kinase
    • Gene
    • Leukemia
    • Mutations
    • Tyrosine
    • Approved
    • Myeloid
    • Treatment
    • Acute
  • receptor tyrosine kinase
    • Kinase
    • Tyrosine
    • Receptor
    • Cytokine
    • Cd135
    • Differentiation
    • Activity
    • Gene
    • Cell
    • Flt3
    • Cluster
    • Flt3l
  • b cell
    • Activity
    • Differentiation
    • Surface
    • Tyrosine
    • Chromosome
    • Location
    • Protein
    • Kinase
    • Bp
    • Chr
    • Hematopoietic
    • Human
  • t cell
    • Activity
    • Differentiation
    • Surface
    • Tyrosine
    • Chromosome
    • Location
    • Protein
    • Kinase
    • Bp
    • Chr
    • Hematopoietic
    • Human
  • cluster of differentiation
    • Differentiation
    • Cell
    • Tyrosine
    • Cytokine
    • Protein
    • Kinase
    • Activity
    • Gene
    • Cd135
    • Surface
    • Also
    • Mouse

Connections between topic areas Semantic bridges

For CD135, one of the stronger structural bridges in this analysis connects CD135 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD135 — Clinical significance · splits 20 ⟂ 20
CD135 — Overview · splits 32 ⟂ 8
CD135 — Function · splits 32 ⟂ 8
CD135 — Structure · splits 37 ⟂ 3

Map overview Semantic statistics

CD135

Nodes40
Edges39
Triples163
Avg. degree1.95
Density0.05
Components1

Source & methodology

TTTA analyzes the structure around CD135 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD135 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.