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CD135

Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3 with fms standing for "feline McDonough sarcoma"), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase…

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2.7.10.1
↗
Aliases
FLT3, CD135, FLK-2, FLK2, STK1, fms related tyrosine kinase 3, fms related receptor tyrosine kinase 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RJB, 3QS7, 3QS9, 4RT7, 4XUF
Band
13q12.2 · 5 86.88 cM|5 G3
Bgee
testicle · cerebellar hemisphere · monocyte · right hemisphere of cerebellum · bone marrow cell
BioGPS
More reference expression data

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Map overview Semantic statistics

CD135

Nodes40
Edges39
Triples163
Avg. degree1.95
Density0.05
Components1

How this topic connects Entity context

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CD135

Top relations

Gene ontology · 64
CD135 → 1-phosphatidylinositol-3-kinase activity, animal organ regeneration, ATP binding, B cell differentiation, cell differentiation, cellular response to cytokine stimulus, cellular response to glucocorticoid stimulus, common myeloid progenitor cell proliferation, cytokine receptor activity, cytokine-mediated signaling pathway, cytoplasm, cytosol, dendritic cell differentiation, endoplasmic reticulum, endoplasmic reticulum lumen, glucocorticoid receptor binding, hematopoietic progenitor cell differentiation, hemopoiesis, integral component of membrane, integral component of plasma membrane
Bgee · 20
CD135 → appendix, body of pancreas, bone marrow cell, cerebellar hemisphere, cochlear nuclei, facial motor nucleus, granulocyte, lymph node, medial preoptic nucleus, mesenteric lymph nodes, monocyte, motor neuron, red nucleus, Region II of hippocampus proper, Region IV of hippocampus proper, right hemisphere of cerebellum, set of nuclei of trapezoid body, spleen, superior olivary complex, testicle
RNA expression pattern · 20
CD135 → appendix, body of pancreas, bone marrow cell, cerebellar hemisphere, cochlear nuclei, facial motor nucleus, granulocyte, lymph node, medial preoptic nucleus, mesenteric lymph nodes, monocyte, motor neuron, red nucleus, Region II of hippocampus proper, Region IV of hippocampus proper, right hemisphere of cerebellum, set of nuclei of trapezoid body, spleen, superior olivary complex, testicle
related to External links · 13
CD135 → Antigen, FLT3, Human FLT3, Medicine Medical Subject Headings, MeSH, National Library, Overview, P36888, PDB, PDBe-KB, Receptor-type, UCSC Genome Browser, UniProt
related to Function · 9
CD135 → FLT3, FLT3-induced, FLT3L, III, Signaling, The, This, Two, When
related to Cell surface marker · 6
CD135 → CD, CLP, Cluster, HSC, In, MPPs
related to Role in cancer · 5
CD135 → AML, FLT3, FLT3-ITD, Internal, Mutations
Band · 2
CD135 → 13q12.2, 5 86.88 cM|5 G3
Chr. · 2
CD135 → Chromosome 13 (human), Chromosome 5 (mouse)
End · 2
CD135 → 147,337,299 bp, 28,100,592 bp

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Important terminology

flt3 kinase receptor tyrosine gene aml bp leukemia mutations human cell chr band cytokine patients activity cells hematopoietic differentiation acute

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD1352.7.10.1↗1.00infobox
CD135AliasesFLT3, CD135, FLK-2, FLK2, STK1, fms related tyrosine kinase 3, fms related receptor tyrosine kinase 31.00infobox
CD135Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RJB, 3QS7, 3QS9, 4RT7, 4XUF1.00infobox
CD135Band13q12.21.00infobox
CD135Band5 86.88 cM|5 G31.00infobox
CD135Bgeetesticle1.00infobox
CD135Bgeecerebellar hemisphere1.00infobox
CD135Bgeemonocyte1.00infobox
CD135Bgeeright hemisphere of cerebellum1.00infobox
CD135Bgeebone marrow cell1.00infobox
CD135Bgeelymph node1.00infobox
CD135Bgeegranulocyte1.00infobox
CD135Bgeebody of pancreas1.00infobox
CD135Bgeespleen1.00infobox
CD135Bgeeappendix1.00infobox
CD135Bgeesuperior olivary complex1.00infobox
CD135Bgeefacial motor nucleus1.00infobox
CD135Bgeered nucleus1.00infobox
CD135Bgeemesenteric lymph nodes1.00infobox
CD135Bgeeset of nuclei of trapezoid body1.00infobox
CD135Bgeecochlear nuclei1.00infobox
CD135Bgeemotor neuron1.00infobox
CD135Bgeemedial preoptic nucleus1.00infobox
CD135BgeeRegion IV of hippocampus proper1.00infobox
CD135BgeeRegion II of hippocampus proper1.00infobox
CD135BioGPSMore reference expression data1.00infobox
CD135Chr.Chromosome 13 (human)1.00infobox
CD135Chr.Chromosome 5 (mouse)1.00infobox
CD135DatabasesNCBI: entry; OMA: entry1.00infobox
CD135End28,100,592 bp1.00infobox

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