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Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placentals and marsupials). SRY is an intronless sex-determining gene on the Y…
The analysis highlights Regions, Gene evolution and regulation and SRY disorders' influence on sex expression as prominent areas in the source structure around Sex-determining region Y protein.
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The extracted context around Sex-determining region Y protein shows recurring relationship patterns in the source. For example, Sex-determining region Y protein → calmodulin binding, cell differentiation, central nervous system development, cytoplasm, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, male sex determination, negative regulation of transcription by RNA polymerase II, neuron differentiation, nuclear speck, nucleoplasm, nucleus, positive regulation of gene expression, positive regulation of male gonad development, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein binding, regulation of transcription by RNA polymerase II Another extracted example is Sex-determining region Y protein → Achilles tendon, ankle joint, aortic valve, ascending aorta, condyle, cumulus cell, epithelium of small intestine, gonad, Ileal epithelium, islet of Langerhans, lacrimal gland, left testis, right adrenal cortex, right testis, salivary gland, skin of abdomen, skin of leg, supraoptic nucleus, tendon of biceps brachii, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
sry gene sex sox9 transcription development male factor chromosome protein also testis region human female bp binding xx xy individuals
TTTA extracted 106 structured relationships around Sex-determining region Y protein. Examples in this analysis include Sex-determining region Y protein → Aliases → SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y and Sex-determining region Y protein → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HRY, 1HRZ, 1J46, 1J47, 2GZK. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Sex-determining region Y protein | Aliases | SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y | 1.00 | infobox |
| Sex-determining region Y protein | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HRY, 1HRZ, 1J46, 1J47, 2GZK | 1.00 | infobox |
| Sex-determining region Y protein | Band | Yp11.2 | 1.00 | infobox |
| Sex-determining region Y protein | Band | Y|Ypter | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | gonad | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | tendon of biceps brachii | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | right testis | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | left testis | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | skin of abdomen | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | islet of Langerhans | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | Achilles tendon | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | skin of leg | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | ventricular zone | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | right adrenal cortex | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | ankle joint | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | ascending aorta | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | aortic valve | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | epithelium of small intestine | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | cumulus cell | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | Ileal epithelium | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | supraoptic nucleus | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | salivary gland | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | condyle | 1.00 | infobox |
| Sex-determining region Y protein | Bgee | lacrimal gland | 1.00 | infobox |
| Sex-determining region Y protein | BioGPS | More reference expression data | 1.00 | infobox |
| Sex-determining region Y protein | Chr. | Y chromosome (human) | 1.00 | infobox |
| Sex-determining region Y protein | Chr. | Y chromosome (mouse) | 1.00 | infobox |
| Sex-determining region Y protein | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Sex-determining region Y protein | End | 2,787,682 bp | 1.00 | infobox |
| Sex-determining region Y protein | End | 2,663,658 bp | 1.00 | infobox |
The concept neighborhoods around Sex-determining region Y protein bring nearby vocabulary together. In this analysis, examples include Sex-determining, Human and Wt1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Sex-determining region Y protein, one of the stronger structural bridges in this analysis connects Sex-determining region Y protein with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Sex-determining region Y protein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Gene evolution and regulation & SRY disorders' influence on sex expression, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Sex-determining region Y protein · EN edition · Analysis: TopicsToTalkAbout