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Sex-determining region Y protein: Regions, Gene evolution and regulation & SRY disorders' influence on sex expression

Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placentals and marsupials). SRY is an intronless sex-determining gene on the Y…

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Sex-determining region Y protein topic overview

The analysis highlights Regions, Gene evolution and regulation and SRY disorders' influence on sex expression as prominent areas in the source structure around Sex-determining region Y protein.

Related topics
94
Source areas
4
Connected nodes
98
Extracted relationships
106
Concept neighborhoods
31
Bridge connections
98

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 30 topics
SRY disorders' influence on sex expression · 30 topics
Gene evolution and regulation · 20 topics
Function · 14 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HRY, 1HRZ, 1J46, 1J47, 2GZK
Band
Yp11.2 · Y|Ypter
Bgee
gonad · tendon of biceps brachii · right testis · left testis · skin of abdomen
BioGPS
More reference expression data
Chr.
Y chromosome (human) · Y chromosome (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene evolution and regulation

Function

SRY disorders' influence on sex expression

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Sex-determining region Y protein connects Entity context

The extracted context around Sex-determining region Y protein shows recurring relationship patterns in the source. For example, Sex-determining region Y protein → calmodulin binding, cell differentiation, central nervous system development, cytoplasm, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, male sex determination, negative regulation of transcription by RNA polymerase II, neuron differentiation, nuclear speck, nucleoplasm, nucleus, positive regulation of gene expression, positive regulation of male gonad development, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein binding, regulation of transcription by RNA polymerase II Another extracted example is Sex-determining region Y protein → Achilles tendon, ankle joint, aortic valve, ascending aorta, condyle, cumulus cell, epithelium of small intestine, gonad, Ileal epithelium, islet of Langerhans, lacrimal gland, left testis, right adrenal cortex, right testis, salivary gland, skin of abdomen, skin of leg, supraoptic nucleus, tendon of biceps brachii, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Sex-determining region Y protein

Top relations

Gene ontology · 25
Sex-determining region Y protein → calmodulin binding, cell differentiation, central nervous system development, cytoplasm, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, male sex determination, negative regulation of transcription by RNA polymerase II, neuron differentiation, nuclear speck, nucleoplasm, nucleus, positive regulation of gene expression, positive regulation of male gonad development, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein binding, regulation of transcription by RNA polymerase II
Bgee · 20
Sex-determining region Y protein → Achilles tendon, ankle joint, aortic valve, ascending aorta, condyle, cumulus cell, epithelium of small intestine, gonad, Ileal epithelium, islet of Langerhans, lacrimal gland, left testis, right adrenal cortex, right testis, salivary gland, skin of abdomen, skin of leg, supraoptic nucleus, tendon of biceps brachii, ventricular zone
RNA expression pattern · 20
Sex-determining region Y protein → Achilles tendon, ankle joint, aortic valve, ascending aorta, condyle, cumulus cell, epithelium of small intestine, gonad, Ileal epithelium, islet of Langerhans, lacrimal gland, left testis, right adrenal cortex, right testis, salivary gland, skin of abdomen, skin of leg, supraoptic nucleus, tendon of biceps brachii, ventricular zone
related to External links · 12
Sex-determining region Y protein → Genes, Human Sex-determining, Medicine Medical Subject Headings, MeSH, National Library, OMIM, PDB, Protein, Region, Sex DevelopmentPDBe-KB, Sex-Determining, XX Testicular Disorder
Band · 2
Sex-determining region Y protein → Yp11.2, Y|Ypter
Chr. · 2
Sex-determining region Y protein → Y chromosome (human), Y chromosome (mouse)
End · 2
Sex-determining region Y protein → 2,663,658 bp, 2,787,682 bp
Aliases · 1
Sex-determining region Y protein → SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y
Available structures · 1
Sex-determining region Y protein → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HRY, 1HRZ, 1J46, 1J47, 2GZK
BioGPS · 1
Sex-determining region Y protein → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

sry gene sex sox9 transcription development male factor chromosome protein also testis region human female bp binding xx xy individuals

Sex-determining region Y protein relationships Subject–Predicate–Object triples

TTTA extracted 106 structured relationships around Sex-determining region Y protein. Examples in this analysis include Sex-determining region Y protein → Aliases → SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y and Sex-determining region Y protein → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HRY, 1HRZ, 1J46, 1J47, 2GZK. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Sex-determining region Y proteinAliasesSRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y1.00infobox
Sex-determining region Y proteinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HRY, 1HRZ, 1J46, 1J47, 2GZK1.00infobox
Sex-determining region Y proteinBandYp11.21.00infobox
Sex-determining region Y proteinBandY|Ypter1.00infobox
Sex-determining region Y proteinBgeegonad1.00infobox
Sex-determining region Y proteinBgeetendon of biceps brachii1.00infobox
Sex-determining region Y proteinBgeeright testis1.00infobox
Sex-determining region Y proteinBgeeleft testis1.00infobox
Sex-determining region Y proteinBgeeskin of abdomen1.00infobox
Sex-determining region Y proteinBgeeislet of Langerhans1.00infobox
Sex-determining region Y proteinBgeeAchilles tendon1.00infobox
Sex-determining region Y proteinBgeeskin of leg1.00infobox
Sex-determining region Y proteinBgeeventricular zone1.00infobox
Sex-determining region Y proteinBgeeright adrenal cortex1.00infobox
Sex-determining region Y proteinBgeeankle joint1.00infobox
Sex-determining region Y proteinBgeeascending aorta1.00infobox
Sex-determining region Y proteinBgeeaortic valve1.00infobox
Sex-determining region Y proteinBgeeepithelium of small intestine1.00infobox
Sex-determining region Y proteinBgeecumulus cell1.00infobox
Sex-determining region Y proteinBgeeIleal epithelium1.00infobox
Sex-determining region Y proteinBgeesupraoptic nucleus1.00infobox
Sex-determining region Y proteinBgeesalivary gland1.00infobox
Sex-determining region Y proteinBgeecondyle1.00infobox
Sex-determining region Y proteinBgeelacrimal gland1.00infobox
Sex-determining region Y proteinBioGPSMore reference expression data1.00infobox
Sex-determining region Y proteinChr.Y chromosome (human)1.00infobox
Sex-determining region Y proteinChr.Y chromosome (mouse)1.00infobox
Sex-determining region Y proteinDatabasesNCBI: entry; OMA: entry1.00infobox
Sex-determining region Y proteinEnd2,787,682 bp1.00infobox
Sex-determining region Y proteinEnd2,663,658 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Sex-determining region Y protein bring nearby vocabulary together. In this analysis, examples include Sex-determining, Human and Wt1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Sex-determining region Y protein
    • Sex-determining
    • Human
    • Wt1
    • Promoter
    • Factors
    • Binding
    • Protein
    • Region
    • Also
    • Sex
    • Chromosome
    • Factor
  • sex-determining region y protein
    • Sex-determining
    • Transcription
    • Human
    • Factor
    • Also
    • Wt1
    • Determination
    • Bp
    • Promoter
    • Sex
    • Factors
    • Binding
  • dna-binding protein
    • Transcription
    • Factor
    • Determination
    • Sex-determining
    • Human
    • Binding
    • Sry
    • Region
    • Sex
    • Band
    • Dna-binding
    • Protein
  • transcription factor
    • Transcription
    • Sox9
    • Protein
    • Also
    • Dna-binding
    • Nucleus
    • Expression
    • Sry
    • Human
    • Binding
    • Region
    • Sex
  • gene
    • Sry
    • Chromosome
    • Sex
    • Transcription
    • Sox9
    • Female
    • Individuals
    • Protein
    • Determination
    • Nucleus
    • Male
    • Binding
  • sex determination
    • Development
    • Determination
    • Sex
    • Dna-binding
    • Protein
    • Differentiation
    • Expression
    • Sry
    • Band
    • Sex-determining
    • Factor
    • Gene
  • sex
    • Development
    • Determination
    • Differentiation
    • Expression
    • Sry
    • Sex-determining
    • Human
    • Individuals
    • Testis
    • Chromosome
    • Chr
    • Nucleus
  • y chromosome
    • Human
    • Chr
    • Bp
    • Band
    • Gene
    • Expression
    • Testis
    • Sry
    • Nucleus
    • Sex-determining
    • Development
    • Differentiation

Connections between topic areas Semantic bridges

For Sex-determining region Y protein, one of the stronger structural bridges in this analysis connects Sex-determining region Y protein with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Sex-determining region Y proteinOverview · splits 68 ⟂ 31
Sex-determining region Y proteinSRY disorders' influence on sex expression · splits 68 ⟂ 31
Sex-determining region Y proteinGene evolution and regulation · splits 78 ⟂ 21
Sex-determining region Y proteinFunction · splits 84 ⟂ 15

Map overview Semantic statistics

Sex-determining region Y protein

Nodes99
Edges98
Triples106
Avg. degree1.98
Density0.020202
Components1

Source & methodology

TTTA analyzes the structure around Sex-determining region Y protein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Gene evolution and regulation & SRY disorders' influence on sex expression, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Sex-determining region Y protein · EN edition · Analysis: TopicsToTalkAbout

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