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RAB7A: Interactions, Clinical significance & Regulation

Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene.

Language: English [EN]
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RAB7A topic overview

The analysis highlights Interactions, Clinical significance and Regulation as prominent areas in the source structure around RAB7A.

Related topics
68
Source areas
7
Connected nodes
75
Extracted relationships
200
Concept neighborhoods
21
Bridge connections
75

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 18 topics
Clinical significance · 13 topics
Regulation · 12 topics
Function · 8 topics
Gene · 8 topics
Overview · 8 topics
Tissue distribution · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.6.5.2
Aliases
RAB7A, PRO2706, RAB7, member RAS oncogene family, CMT2B
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1T91, 1YHN, 3LAW
Band
3q21.3 · 6 D1|6 39.13 cM
Bgee
stromal cell of endometrium · right lung · C1 segment · monocyte · gastrocnemius muscle
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Tissue distribution

Gene

Regulation

Interactions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How RAB7A connects Entity context

The extracted context around RAB7A shows recurring relationship patterns in the source. For example, RAB7A → alveolar lamellar body, antigen processing and presentation of exogenous peptide antigen via MHC class II, autophagosome assembly, autophagosome membrane, autophagy, bone resorption, cytoplasm, cytoplasmic vesicle, cytosol, early endosome to late endosome transport, endocytosis, endosome, endosome membrane, endosome to lysosome transport, epidermal growth factor catabolic process, extracellular exosome, extrinsic component of lysosome membrane, GDP binding, Golgi apparatus, GTP binding Another extracted example is RAB7A → C1 segment, dentate gyrus of hippocampal formation granule cell, epithelium of colon, gastrocnemius muscle, genital tubercle, granulocyte, hippocampus proper, left adrenal gland, monocyte, muscle of thigh, prefrontal cortex, primary oocyte, right adrenal cortex, right lung, secondary oocyte, skeletal muscle tissue, stromal cell of endometrium, tail of embryo, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

RAB7A

Top relations

Gene ontology · 61
RAB7A → alveolar lamellar body, antigen processing and presentation of exogenous peptide antigen via MHC class II, autophagosome assembly, autophagosome membrane, autophagy, bone resorption, cytoplasm, cytoplasmic vesicle, cytosol, early endosome to late endosome transport, endocytosis, endosome, endosome membrane, endosome to lysosome transport, epidermal growth factor catabolic process, extracellular exosome, extrinsic component of lysosome membrane, GDP binding, Golgi apparatus, GTP binding
Bgee · 19
RAB7A → C1 segment, dentate gyrus of hippocampal formation granule cell, epithelium of colon, gastrocnemius muscle, genital tubercle, granulocyte, hippocampus proper, left adrenal gland, monocyte, muscle of thigh, prefrontal cortex, primary oocyte, right adrenal cortex, right lung, secondary oocyte, skeletal muscle tissue, stromal cell of endometrium, tail of embryo, zygote
RNA expression pattern · 19
RAB7A → C1 segment, dentate gyrus of hippocampal formation granule cell, epithelium of colon, gastrocnemius muscle, genital tubercle, granulocyte, hippocampus proper, left adrenal gland, monocyte, muscle of thigh, prefrontal cortex, primary oocyte, right adrenal cortex, right lung, secondary oocyte, skeletal muscle tissue, stromal cell of endometrium, tail of embryo, zygote
related to Charcot-Marie-Tooth 2B · 15
RAB7A → Also, Charcot, CMT, CMT2B, Currently, GTPase Rab7, HMSN, Marie, Missense, PMA, Rab7, This, Tooth, United Kingdom, United States
related to Melanoma · 15
RAB7A → Analyses, BRAF, Finding, GTPase RAB7, Importantly, In, It, Lysosomal-associated, Melanoma, MITF, MITF-independent, MYC, Rab7, SOX10, This
related to Gene · 12
RAB7A → Barbosa, Davies, Finally, FISH, In, Kashuba, PCR, Rab7, The, The RAB7A, Using Northern Blot Analysis, Vitelli
related to Regulation · 12
RAB7A → Chédiak, HeLa, Higashi, In, It, MITF, MITF-independent, MYC, RAB7, RNA, SOX10, Studies
related to Clinical significance · 10
RAB7A → GDP, GTP, GTPase, GTPases, It, RAB, RAB7, RAS, The RAB7A, These
related to Function · 7
RAB7A → Helicobacter, In, Members, RAB, RAB7, RAS-related GTP-binding, VacA
related to Interactions · 5
RAB7A → CHM, GTP, Rab7, RILP, Rubicon

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

rab7 gene cell protein vesicle human sox10 cells chromosome bp melanoma myc membrane chr band function oncogene rab mouse endocytosis

RAB7A relationships Subject–Predicate–Object triples

TTTA extracted 200 structured relationships around RAB7A. Examples in this analysis include RAB7A → 3.6.5.2 → ↗ and RAB7A → Aliases → RAB7A, PRO2706, RAB7, member RAS oncogene family, CMT2B. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
RAB7A3.6.5.21.00infobox
RAB7AAliasesRAB7A, PRO2706, RAB7, member RAS oncogene family, CMT2B1.00infobox
RAB7AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1T91, 1YHN, 3LAW1.00infobox
RAB7ABand3q21.31.00infobox
RAB7ABand6 D1|6 39.13 cM1.00infobox
RAB7ABgeestromal cell of endometrium1.00infobox
RAB7ABgeeright lung1.00infobox
RAB7ABgeeC1 segment1.00infobox
RAB7ABgeemonocyte1.00infobox
RAB7ABgeegastrocnemius muscle1.00infobox
RAB7ABgeeprefrontal cortex1.00infobox
RAB7ABgeeright adrenal cortex1.00infobox
RAB7ABgeemuscle of thigh1.00infobox
RAB7ABgeeleft adrenal gland1.00infobox
RAB7ABgeeepithelium of colon1.00infobox
RAB7ABgeesecondary oocyte1.00infobox
RAB7ABgeezygote1.00infobox
RAB7ABgeeprimary oocyte1.00infobox
RAB7ABgeetail of embryo1.00infobox
RAB7ABgeegenital tubercle1.00infobox
RAB7ABgeegranulocyte1.00infobox
RAB7ABgeedentate gyrus of hippocampal formation granule cell1.00infobox
RAB7ABgeehippocampus proper1.00infobox
RAB7ABgeeskeletal muscle tissue1.00infobox
RAB7ABioGPSMore reference expression data1.00infobox
RAB7AChr.Chromosome 3 (human)1.00infobox
RAB7AChr.Chromosome 6 (mouse)1.00infobox
RAB7ADatabasesNCBI: entry; OMA: entry1.00infobox
RAB7AEnd128,825,942 bp1.00infobox
RAB7AEnd88,022,252 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around RAB7A bring nearby vocabulary together. In this analysis, examples include Gene, Oncogene and Myc. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • RAB7A
    • Gene
    • Oncogene
    • Myc
    • Sox10
    • Function
    • Chromosome
    • Also
    • Location
    • Using
    • Levels
    • Trafficking
    • Human
  • rab7a
    • Gene
    • Oncogene
    • Myc
    • Sox10
    • Function
    • Chromosome
    • Also
    • Location
    • Using
    • Levels
    • Trafficking
    • Human
  • protein
    • Endocytosis
    • Process
    • Ras-related
    • Cell
    • Membrane
    • Mouse
    • Vesicle
    • Human
    • Gene
    • Rab7a
    • Band
    • Expressed
  • gene
    • Chromosome
    • Location
    • Rab7a
    • Gtpase
    • Using
    • Bp
    • Chr
    • Human
    • Melanoma
    • Rab7
    • Ras-related
    • Band
  • cell membrane
    • Vesicle
    • Membrane
    • Endocytosis
    • Process
    • Protein
    • Cells
    • Ras-related
    • Expressed
    • Important
    • Using
    • Expression
    • Proteins
  • vesicle
    • Membrane
    • Cell
    • Endocytosis
    • Process
    • Important
    • Rab
    • Proteins
    • Trafficking
    • Protein
    • Ras-related
    • Band
    • Expressed
  • chromosome 3
    • Location
    • Bp
    • Human
    • Band
    • Gene
    • Mouse
    • Function
    • Rab7a
    • Endocytosis
    • Process
    • Ras-related
    • Expressed
  • gene cluster
    • Chromosome
    • Location
    • Rab7a
    • Gtpase
    • Using
    • Bp
    • Chr
    • Human
    • Melanoma
    • Rab7
    • Ras-related
    • Band

Connections between topic areas Semantic bridges

For RAB7A, one of the stronger structural bridges in this analysis connects RAB7A with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
RAB7AInteractions · splits 57 ⟂ 19
RAB7AClinical significance · splits 62 ⟂ 14
RAB7ARegulation · splits 63 ⟂ 13
RAB7AOverview · splits 67 ⟂ 9
RAB7AFunction · splits 67 ⟂ 9
RAB7AGene · splits 67 ⟂ 9

Map overview Semantic statistics

RAB7A

Nodes76
Edges75
Triples200
Avg. degree1.97
Density0.026316
Components1

Source & methodology

TTTA analyzes the structure around RAB7A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Clinical significance & Regulation, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — RAB7A · EN edition · Analysis: TopicsToTalkAbout

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