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PSMC5

26S protease regulatory subunit 8, also known as 26S proteasome AAA-ATPase subunit Rpt6, is an enzyme that in humans is encoded by the PSMC5 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2, Rpt3, Rpt4, Rpt5, and Rpt6 (this protein)) together with four…

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Complex assembly

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Aliases
PSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG, proteasome 26S subunit, ATPase 5, RPT6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KRK, 3KW6
Band
17q23.3 · 11|11 E1
Bgee
tendon of biceps brachii · cerebellar cortex · cerebellar hemisphere · right hemisphere of cerebellum · right testis
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Overview

Complex assembly

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PSMC5

Nodes21
Edges20
Triples135
Avg. degree1.9
Density0.095238
Components1

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PSMC5

Top relations

Gene ontology · 60
PSMC5 → anaphase-promoting complex-dependent catabolic process, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, ATP binding, ATPase activity, blood microparticle, cytoplasm, cytoplasmic vesicle, cytosol, cytosolic proteasome complex, extracellular exosome, Fc-epsilon receptor signaling pathway, hydrolase activity, inclusion body, interleukin-1-mediated signaling pathway, MAPK cascade, membrane, modulation of chemical synaptic transmission, negative regulation of canonical Wnt signaling pathway, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of programmed cell death
Bgee · 20
PSMC5 → anterior pituitary, cerebellar cortex, cerebellar hemisphere, deep cerebellar nuclei, dorsal tegmental nucleus, gastric mucosa, gastrocnemius muscle, habenula, islet of Langerhans, left testis, medial vestibular nucleus, otic placode, otic vesicle, pontine nuclei, right hemisphere of cerebellum, right testis, saccule, somite, tail of embryo, tendon of biceps brachii
RNA expression pattern · 20
PSMC5 → anterior pituitary, cerebellar cortex, cerebellar hemisphere, deep cerebellar nuclei, dorsal tegmental nucleus, gastric mucosa, gastrocnemius muscle, habenula, islet of Langerhans, left testis, medial vestibular nucleus, otic placode, otic vesicle, pontine nuclei, right hemisphere of cerebellum, right testis, saccule, somite, tail of embryo, tendon of biceps brachii
related to Children with PSMC5 Mutations · 5
PSMC5 → As, GeneMatcher, PSMC5 Foundation, The, There
related to Gene · 4
PSMC5 → ATPase, ATPases, In, The
related to Interactions · 3
PSMC5 → PSMC3, PSMC4, Sp1
Band · 2
PSMC5 → 11|11 E1, 17q23.3
Chr. · 2
PSMC5 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
PSMC5 → 106,153,946 bp, 63,832,026 bp
Aliases · 1
PSMC5 → PSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG, proteasome 26S subunit, ATPase 5, RPT6

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Important terminology

19s regulatory protein proteasome subunits complex particle subunit gene 26s human bp base band rpt6 chr chromosome rpt5 rpn13 assembly

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PSMC5AliasesPSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG, proteasome 26S subunit, ATPase 5, RPT61.00infobox
PSMC5Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KRK, 3KW61.00infobox
PSMC5Band17q23.31.00infobox
PSMC5Band11|11 E11.00infobox
PSMC5Bgeetendon of biceps brachii1.00infobox
PSMC5Bgeecerebellar cortex1.00infobox
PSMC5Bgeecerebellar hemisphere1.00infobox
PSMC5Bgeeright hemisphere of cerebellum1.00infobox
PSMC5Bgeeright testis1.00infobox
PSMC5Bgeegastrocnemius muscle1.00infobox
PSMC5Bgeeleft testis1.00infobox
PSMC5Bgeeanterior pituitary1.00infobox
PSMC5Bgeegastric mucosa1.00infobox
PSMC5Bgeeislet of Langerhans1.00infobox
PSMC5Bgeeotic placode1.00infobox
PSMC5Bgeesaccule1.00infobox
PSMC5Bgeemedial vestibular nucleus1.00infobox
PSMC5Bgeedeep cerebellar nuclei1.00infobox
PSMC5Bgeedorsal tegmental nucleus1.00infobox
PSMC5Bgeepontine nuclei1.00infobox
PSMC5Bgeetail of embryo1.00infobox
PSMC5Bgeesomite1.00infobox
PSMC5Bgeeotic vesicle1.00infobox
PSMC5Bgeehabenula1.00infobox
PSMC5BioGPSMore reference expression data1.00infobox
PSMC5Chr.Chromosome 17 (human)1.00infobox
PSMC5Chr.Chromosome 11 (mouse)1.00infobox
PSMC5DatabasesNCBI: entry; OMA: entry1.00infobox
PSMC5End63,832,026 bp1.00infobox
PSMC5End106,153,946 bp1.00infobox

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