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PSMC5: Measurement, Interactions & Overview

26S protease regulatory subunit 8, also known as 26S proteasome AAA-ATPase subunit Rpt6, is an enzyme that in humans is encoded by the PSMC5 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2, Rpt3, Rpt4, Rpt5, and Rpt6 (this protein)) together with four…

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PSMC5 topic overview

The analysis highlights Measurement, Interactions and Overview as prominent areas in the source structure around PSMC5.

Related topics
17
Source areas
3
Connected nodes
20
Extracted relationships
135
Concept neighborhoods
12
Bridge connections
20

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 12 topics
Interactions · 3 topics
Complex assembly · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG, proteasome 26S subunit, ATPase 5, RPT6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KRK, 3KW6
Band
17q23.3 · 11|11 E1
Bgee
tendon of biceps brachii · cerebellar cortex · cerebellar hemisphere · right hemisphere of cerebellum · right testis
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Complex assembly

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PSMC5 connects Entity context

The extracted context around PSMC5 shows recurring relationship patterns in the source. For example, PSMC5 → anaphase-promoting complex-dependent catabolic process, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, ATP binding, ATPase activity, blood microparticle, cytoplasm, cytoplasmic vesicle, cytosol, cytosolic proteasome complex, extracellular exosome, Fc-epsilon receptor signaling pathway, hydrolase activity, inclusion body, interleukin-1-mediated signaling pathway, MAPK cascade, membrane, modulation of chemical synaptic transmission, negative regulation of canonical Wnt signaling pathway, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of programmed cell death Another extracted example is PSMC5 → anterior pituitary, cerebellar cortex, cerebellar hemisphere, deep cerebellar nuclei, dorsal tegmental nucleus, gastric mucosa, gastrocnemius muscle, habenula, islet of Langerhans, left testis, medial vestibular nucleus, otic placode, otic vesicle, pontine nuclei, right hemisphere of cerebellum, right testis, saccule, somite, tail of embryo, tendon of biceps brachii. Use these groups to spot repeated connection types before inspecting the individual relationships.

PSMC5

Top relations

Gene ontology · 60
PSMC5 → anaphase-promoting complex-dependent catabolic process, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, ATP binding, ATPase activity, blood microparticle, cytoplasm, cytoplasmic vesicle, cytosol, cytosolic proteasome complex, extracellular exosome, Fc-epsilon receptor signaling pathway, hydrolase activity, inclusion body, interleukin-1-mediated signaling pathway, MAPK cascade, membrane, modulation of chemical synaptic transmission, negative regulation of canonical Wnt signaling pathway, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of programmed cell death
Bgee · 20
PSMC5 → anterior pituitary, cerebellar cortex, cerebellar hemisphere, deep cerebellar nuclei, dorsal tegmental nucleus, gastric mucosa, gastrocnemius muscle, habenula, islet of Langerhans, left testis, medial vestibular nucleus, otic placode, otic vesicle, pontine nuclei, right hemisphere of cerebellum, right testis, saccule, somite, tail of embryo, tendon of biceps brachii
RNA expression pattern · 20
PSMC5 → anterior pituitary, cerebellar cortex, cerebellar hemisphere, deep cerebellar nuclei, dorsal tegmental nucleus, gastric mucosa, gastrocnemius muscle, habenula, islet of Langerhans, left testis, medial vestibular nucleus, otic placode, otic vesicle, pontine nuclei, right hemisphere of cerebellum, right testis, saccule, somite, tail of embryo, tendon of biceps brachii
related to Children with PSMC5 Mutations · 5
PSMC5 → As, GeneMatcher, PSMC5 Foundation, The, There
related to Gene · 4
PSMC5 → ATPase, ATPases, In, The
related to Interactions · 3
PSMC5 → PSMC3, PSMC4, Sp1
Band · 2
PSMC5 → 11|11 E1, 17q23.3
Chr. · 2
PSMC5 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
PSMC5 → 106,153,946 bp, 63,832,026 bp
Aliases · 1
PSMC5 → PSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG, proteasome 26S subunit, ATPase 5, RPT6

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

19s regulatory protein proteasome subunits complex particle subunit gene 26s human bp base band rpt6 chr chromosome rpt5 rpn13 assembly

PSMC5 relationships Subject–Predicate–Object triples

TTTA extracted 135 structured relationships around PSMC5. Examples in this analysis include PSMC5 → Aliases → PSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG, proteasome 26S subunit, ATPase 5, RPT6 and PSMC5 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KRK, 3KW6. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PSMC5AliasesPSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG, proteasome 26S subunit, ATPase 5, RPT61.00infobox
PSMC5Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KRK, 3KW61.00infobox
PSMC5Band17q23.31.00infobox
PSMC5Band11|11 E11.00infobox
PSMC5Bgeetendon of biceps brachii1.00infobox
PSMC5Bgeecerebellar cortex1.00infobox
PSMC5Bgeecerebellar hemisphere1.00infobox
PSMC5Bgeeright hemisphere of cerebellum1.00infobox
PSMC5Bgeeright testis1.00infobox
PSMC5Bgeegastrocnemius muscle1.00infobox
PSMC5Bgeeleft testis1.00infobox
PSMC5Bgeeanterior pituitary1.00infobox
PSMC5Bgeegastric mucosa1.00infobox
PSMC5Bgeeislet of Langerhans1.00infobox
PSMC5Bgeeotic placode1.00infobox
PSMC5Bgeesaccule1.00infobox
PSMC5Bgeemedial vestibular nucleus1.00infobox
PSMC5Bgeedeep cerebellar nuclei1.00infobox
PSMC5Bgeedorsal tegmental nucleus1.00infobox
PSMC5Bgeepontine nuclei1.00infobox
PSMC5Bgeetail of embryo1.00infobox
PSMC5Bgeesomite1.00infobox
PSMC5Bgeeotic vesicle1.00infobox
PSMC5Bgeehabenula1.00infobox
PSMC5BioGPSMore reference expression data1.00infobox
PSMC5Chr.Chromosome 17 (human)1.00infobox
PSMC5Chr.Chromosome 11 (mouse)1.00infobox
PSMC5DatabasesNCBI: entry; OMA: entry1.00infobox
PSMC5End63,832,026 bp1.00infobox
PSMC5End106,153,946 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PSMC5 bring nearby vocabulary together. In this analysis, examples include Chromosome, Human and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • proteasome
    • Complex
    • Atpase
    • One
    • Subunit
    • Rpt6
    • Psmc5
    • Regulatory
    • Subunits
    • Location
    • Rpn10
    • Particle
    • Rpn13
  • complex assembly
    • Base
    • Sub
    • Assembly
    • Complex
    • Location
    • Proteasome
    • Atpase
    • Protein
    • Bp
    • Chr
    • Chromosome
    • Gene
  • gene
    • Chromosome
    • Location
    • Human
    • Psmc5
    • Band
    • Bp
    • Chr
    • Atpase
    • Proteasome
    • Assembly
    • Rpt6
    • Subunit
  • PSMC5
    • Chromosome
    • Human
    • Location
    • Mutations
    • Atpase
    • One
    • Assembly
    • Band
    • Bp
    • Chr
    • Rpt6
    • Subunit
  • psmc5
    • Chromosome
    • Human
    • Location
    • Mutations
    • Atpase
    • One
    • Assembly
    • Band
    • Bp
    • Chr
    • Rpt6
    • Subunit
  • rpt1
    • Rpt3
    • Rpt2
    • Rpt5
    • Rpt6
    • Rpn1
    • Rpn10
    • Atpases
    • Cp
    • Ring
    • Rpn13
    • Sub
    • Subunits
  • rpt2
    • Rpt3
    • Rpt5
    • Rpt6
    • Subunit
    • Rpn1
    • Rpn10
    • Atpases
    • Cp
    • Ring
    • Rpn13
    • Sub
    • Subunits
  • rpn1
    • Rpn10
    • Ring
    • Rpn13
    • Rpt1
    • Rpt3
    • Atpases
    • Rpt2
    • Rpt5
    • Sub
    • Three
    • Rpt6
    • Subunits

Connections between topic areas Semantic bridges

For PSMC5, one of the stronger structural bridges in this analysis connects PSMC5 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PSMC5Overview · splits 8 ⟂ 13
PSMC5Interactions · splits 17 ⟂ 4
PSMC5Complex assembly · splits 18 ⟂ 3

Map overview Semantic statistics

PSMC5

Nodes21
Edges20
Triples135
Avg. degree1.9
Density0.095238
Components1

Source & methodology

TTTA analyzes the structure around PSMC5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PSMC5 · EN edition · Analysis: TopicsToTalkAbout

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