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Prostaglandin EP4 receptor: Expression, Mechanism of cell activation & Functions

Prostaglandin E2 receptor 4 (EP4) is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans. It is one of four identified EP receptors, the others being EP1, EP2, and EP3, all of which bind with and mediate cellular responses to PGE2 and also, but generally with lesser affinity and responsiveness, certain other…

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Prostaglandin EP4 receptor topic overview

The analysis highlights Expression, Mechanism of cell activation and Functions as prominent areas in the source structure around Prostaglandin EP4 receptor.

Related topics
135
Source areas
7
Connected nodes
142
Extracted relationships
102
Concept neighborhoods
37
Bridge connections
142

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Functions · 46 topics
Mechanism of cell activation · 30 topics
Expression · 20 topics
Clinical significance · 19 topics
Ligands · 13 topics
Overview · 5 topics
Gene · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PTGER4, EP4, EP4R, EP4 receptor, prostaglandin E receptor 4
Band
5p13.1 · 15 A1|15 1.99 cM
Bgee
palpebral conjunctiva · jejunal mucosa · glomerulus · mucosa of sigmoid colon · metanephric glomerulus
BioGPS
n/a
Chr.
Chromosome 5 (human) · Chromosome 15 (mouse)
Databases
NCBI: entry; OMA: entry

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Less obvious directions

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Expression

Ligands

Mechanism of cell activation

Functions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Prostaglandin EP4 receptor connects Entity context

The extracted context around Prostaglandin EP4 receptor shows recurring relationship patterns in the source. For example, Prostaglandin EP4 receptor → adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, bone development, cellular response to mechanical stimulus, cellular response to prostaglandin E stimulus, ERK1 and ERK2 cascade, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, immune response, inflammatory response, integral component of membrane, intracellular anatomical structure, JNK cascade, membrane, negative regulation of eosinophil extravasation, negative regulation of inflammatory response, negative regulation of integrin activation, plasma membrane, positive regulation of cytosolic calcium ion concentration, positive regulation of inflammatory response Another extracted example is Prostaglandin EP4 receptor → atrioventricular valve, blood, bronchial epithelial cell, conjunctival fornix, germinal epithelium, glomerulus, hair follicle, ileum, jejunal mucosa, left colon, mesenteric lymph nodes, metanephric glomerulus, mucosa of sigmoid colon, palpebral conjunctiva, Paneth cell, parietal pleura, renal corpuscle, synovial joint, uterus, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

Prostaglandin EP4 receptor

Top relations

Gene ontology · 30
Prostaglandin EP4 receptor → adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, bone development, cellular response to mechanical stimulus, cellular response to prostaglandin E stimulus, ERK1 and ERK2 cascade, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, immune response, inflammatory response, integral component of membrane, intracellular anatomical structure, JNK cascade, membrane, negative regulation of eosinophil extravasation, negative regulation of inflammatory response, negative regulation of integrin activation, plasma membrane, positive regulation of cytosolic calcium ion concentration, positive regulation of inflammatory response
Bgee · 20
Prostaglandin EP4 receptor → atrioventricular valve, blood, bronchial epithelial cell, conjunctival fornix, germinal epithelium, glomerulus, hair follicle, ileum, jejunal mucosa, left colon, mesenteric lymph nodes, metanephric glomerulus, mucosa of sigmoid colon, palpebral conjunctiva, Paneth cell, parietal pleura, renal corpuscle, synovial joint, uterus, visceral pleura
RNA expression pattern · 20
Prostaglandin EP4 receptor → atrioventricular valve, blood, bronchial epithelial cell, conjunctival fornix, germinal epithelium, glomerulus, hair follicle, ileum, jejunal mucosa, left colon, mesenteric lymph nodes, metanephric glomerulus, mucosa of sigmoid colon, palpebral conjunctiva, Paneth cell, parietal pleura, renal corpuscle, synovial joint, uterus, visceral pleura
Band · 2
Prostaglandin EP4 receptor → 15 A1|15 1.99 cM, 5p13.1
Chr. · 2
Prostaglandin EP4 receptor → Chromosome 15 (mouse), Chromosome 5 (human)
End · 2
Prostaglandin EP4 receptor → 40,693,735 bp, 5,273,668 bp
Aliases · 1
Prostaglandin EP4 receptor → PTGER4, EP4, EP4R, EP4 receptor, prostaglandin E receptor 4
BioGPS · 1
Prostaglandin EP4 receptor → n/a
Databases · 1
Prostaglandin EP4 receptor → NCBI: entry; OMA: entry
Ensembl · 1
Prostaglandin EP4 receptor → ENSG00000171522

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ep4 receptor gene mice activation human cells prostaglandin studies also ptger4 pge2 humans ductus development cell selective disease may receptors

Prostaglandin EP4 receptor relationships Subject–Predicate–Object triples

TTTA extracted 102 structured relationships around Prostaglandin EP4 receptor. Examples in this analysis include Prostaglandin EP4 receptor → Aliases → PTGER4, EP4, EP4R, EP4 receptor, prostaglandin E receptor 4 and Prostaglandin EP4 receptor → Band → 5p13.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Prostaglandin EP4 receptorAliasesPTGER4, EP4, EP4R, EP4 receptor, prostaglandin E receptor 41.00infobox
Prostaglandin EP4 receptorBand5p13.11.00infobox
Prostaglandin EP4 receptorBand15 A1|15 1.99 cM1.00infobox
Prostaglandin EP4 receptorBgeepalpebral conjunctiva1.00infobox
Prostaglandin EP4 receptorBgeejejunal mucosa1.00infobox
Prostaglandin EP4 receptorBgeeglomerulus1.00infobox
Prostaglandin EP4 receptorBgeemucosa of sigmoid colon1.00infobox
Prostaglandin EP4 receptorBgeemetanephric glomerulus1.00infobox
Prostaglandin EP4 receptorBgeebronchial epithelial cell1.00infobox
Prostaglandin EP4 receptorBgeevisceral pleura1.00infobox
Prostaglandin EP4 receptorBgeesynovial joint1.00infobox
Prostaglandin EP4 receptorBgeegerminal epithelium1.00infobox
Prostaglandin EP4 receptorBgeeparietal pleura1.00infobox
Prostaglandin EP4 receptorBgeerenal corpuscle1.00infobox
Prostaglandin EP4 receptorBgeehair follicle1.00infobox
Prostaglandin EP4 receptorBgeeconjunctival fornix1.00infobox
Prostaglandin EP4 receptorBgeeatrioventricular valve1.00infobox
Prostaglandin EP4 receptorBgeeblood1.00infobox
Prostaglandin EP4 receptorBgeemesenteric lymph nodes1.00infobox
Prostaglandin EP4 receptorBgeeuterus1.00infobox
Prostaglandin EP4 receptorBgeePaneth cell1.00infobox
Prostaglandin EP4 receptorBgeeleft colon1.00infobox
Prostaglandin EP4 receptorBgeeileum1.00infobox
Prostaglandin EP4 receptorBioGPSn/a1.00infobox
Prostaglandin EP4 receptorChr.Chromosome 5 (human)1.00infobox
Prostaglandin EP4 receptorChr.Chromosome 15 (mouse)1.00infobox
Prostaglandin EP4 receptorDatabasesNCBI: entry; OMA: entry1.00infobox
Prostaglandin EP4 receptorEnd40,693,735 bp1.00infobox
Prostaglandin EP4 receptorEnd5,273,668 bp1.00infobox
Prostaglandin EP4 receptorEnsemblENSG000001715221.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Prostaglandin EP4 receptor bring nearby vocabulary together. In this analysis, examples include See, Also and Receptor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Prostaglandin EP4 receptor
    • See
    • Also
    • Receptor
    • Mice
    • Cell
    • Ptger4
    • Cells
    • Pge2
    • Ep2
    • Ep3
    • Gene
    • Selective
  • prostaglandin ep4 receptor
    • See
    • Receptor
    • Also
    • Mice
    • Agonists
    • Cell
    • Ptger4
    • Cells
    • Human
    • Pge2
    • Activation
    • Studies
  • prostaglandin receptor
    • See
    • Also
    • Receptor
    • Agonists
    • Cell
    • Ptger4
    • Human
    • Pge2
    • Studies
    • Ep2
    • Ep3
    • Gene
  • prostaglandin e2
    • See
    • Also
    • Receptor
    • Cell
    • Ptger4
    • Pge2
    • Ep2
    • Ep3
    • Gene
    • Bp
    • Cellular
    • Chr
  • gene
    • Ptger4
    • Human
    • Chromosome
    • Cancer
    • Bp
    • Chr
    • Mouse
    • Expression
    • Cell
    • Receptor
    • Prostaglandin
    • Band
  • prostaglandin receptors
    • See
    • Also
    • Receptor
    • Cell
    • Ptger4
    • Pge2
    • Ep2
    • Ep3
    • Gene
    • Bp
    • Cellular
    • Chr
  • prostaglandin e1
    • See
    • Also
    • Receptor
    • Cell
    • Ptger4
    • Pge2
    • Ep2
    • Ep3
    • Gene
    • Bp
    • Cellular
    • Chr
  • cell signaling
    • Human
    • Cancer
    • Antagonist
    • Prostaglandin
    • Gene
    • Bp
    • Chr
    • Chromosome
    • Clinical
    • See
    • Receptor
    • Activation

Connections between topic areas Semantic bridges

For Prostaglandin EP4 receptor, one of the stronger structural bridges in this analysis connects Prostaglandin EP4 receptor with Functions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Prostaglandin EP4 receptorFunctions · splits 96 ⟂ 47
Prostaglandin EP4 receptorMechanism of cell activation · splits 112 ⟂ 31
Prostaglandin EP4 receptorExpression · splits 122 ⟂ 21
Prostaglandin EP4 receptorClinical significance · splits 123 ⟂ 20
Prostaglandin EP4 receptorLigands · splits 129 ⟂ 14
Prostaglandin EP4 receptorOverview · splits 137 ⟂ 6
Prostaglandin EP4 receptorGene · splits 140 ⟂ 3

Map overview Semantic statistics

Prostaglandin EP4 receptor

Nodes143
Edges142
Triples102
Avg. degree1.99
Density0.013986
Components1

Source & methodology

TTTA analyzes the structure around Prostaglandin EP4 receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Expression, Mechanism of cell activation & Functions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Prostaglandin EP4 receptor · EN edition · Analysis: TopicsToTalkAbout

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