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Prime editing

Prime editing is a 'search-and-replace' genome editing technology in molecular biology by which the genome of living organisms may be modified. The technology directly writes new genetic information into a targeted DNA site. The most basic prime editor uses a fusion protein, consisting of a catalytically-impaired programmable endonuclease linked to an…

Applications & Technology

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Overview

Editing mechanism

PegRNA improvements and modifications

Protein modifications in animals

Applications

Methods of delivery

Comparison to base editors and traditional CRISPR/Cas9 genome editing

Advanced semantic analysis

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Map overview Semantic statistics

Prime editing

Nodes106
Edges105
Triples83
Avg. degree1.98
Density0.018868
Components1

How this topic connects Entity context

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Prime editing

Top relations

related to Advantages · 16
Prime editing → Base, BE, Collectively, CRISPR/Cas9, Cytosine, DNA, HDR, However, NHEJ, PAM, PE, Prime, Remarkably, The, These, This
related to Engineered pegRNA (epegRNA) · 13
Prime editing → Choosing, Degraded, If, MMLV, Moloney, One, PE, Prime, RNA, RT, The, Two RNA, While
has method · 11
Prime editing → AAV, As, Base, Common, However, Introducing, One, RNA, SpCas9-reverse, The, Unfortunately
related to Limitations · 8
Prime editing → An, As, Furthermore, However, Larger, Prime, RT, There
related to PE4 and 5 strategies · 7
Prime editing → Dominant, Like PE4, MLH1, MMR, PE2, PE3, Prime
related to Protein modifications in animals · 7
Prime editing → Anzalone, Broad Institute, David, During, Liu, Prime, Since
related to Nuclease prime editors · 6
Prime editing → Cas9, DNA, H840A, Nuclease Prime Editor, PE3, Unlike
related to Twin prime editing · 4
Prime editing → DNA, It, RNAs, The
related to Animal models · 2
Prime editing → AAVs, Efficient
related to Comparison to base editors and traditional CRISPR/Cas9 genome editing · 2
Prime editing → Although, The

Important terminology Word statistics

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Important terminology

prime editing editor dna rna efficiency protein pegrna cas9 needed reverse transcriptase editors target strand used nickase template detail base

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Prime editingis a'search-and-replace' genome editing technology in molecular biology by which the genome of living organisms may be modified0.90text
lentivirus cause immune responses in humansinstance ofCommon laboratory vectors of transduction0.80text
so proposed human therapies often centered around adeno-associated virusinstance ofCommon laboratory vectors of transduction0.80text
NHEJinstance ofThis is an important feature of this technology given that DNA repair mechanisms0.80text
HDRinstance ofThis is an important feature of this technology given that DNA repair mechanisms0.80text
generate unwantedinstance ofThis is an important feature of this technology given that DNA repair mechanisms0.80text
random insertions or deletionsinstance ofThis is an important feature of this technology given that DNA repair mechanisms0.80text
Prime editinghas methodBase0.60section
Prime editinghas methodRNA0.60section
Prime editinghas methodIntroducing0.60section
Prime editinghas methodOne0.60section
Prime editinghas methodThe0.60section

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