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Chlormethine

Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) embikhin (эмбихин), is a nitrogen mustard sold under the brand name Mustargen among others. It is the prototype of alkylating agents, a group of anticancer chemotherapeutic drugs. It works by binding to DNA, crosslinking two strands and…

History & Applications

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Side effects and toxicity

LacrimationBlepharospasmMiosisEdemaPhotophobia
19 related topics

Uses

EstrogenEstramustine phosphateProstate cancerChemical warfareMustard gas
11 related topics

History

OSRDHN3
2 related topics

Overview

INNBANUSANUSPPost-Soviet states
12 related topics

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Overview

Uses

Side effects and toxicity

History

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Map overview Semantic statistics

Chlormethine

Nodes49
Edges48
Triples34
Avg. degree1.96
Density0.040816
Components1

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Chlormethine

Top relations

related to history · 22
Chlormethine → After, Alfred Gilman, And, August, Bis, Chicago, Development, First World War, HN3, In, Inspired, Louis Goodman, Office, OSRD, Scientific Research, Second World War, The, The OSRD, The Yale, University
related to Uses · 7
Chlormethine → Another, Historically, HN2, It, Mechlorethamine, There, This
related to Chemistry · 1
Chlormethine → It

Important terminology Word statistics

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Important terminology

mechlorethamine exposure nitrogen chemical mustard skin symptoms first agents group damage severe may also hn2 dna effects used cancer chronic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
lymphomainstance ofsome uses of mechlorethamine have included lymphoid malignancies0.80text
chronic myelogenous leukemiainstance ofsome uses of mechlorethamine have included lymphoid malignancies0.80text
polycythemia verainstance ofsome uses of mechlorethamine have included lymphoid malignancies0.80text
and lung cancerinstance ofsome uses of mechlorethamine have included lymphoid malignancies0.80text
Chlormethinerelated to ChemistryIt0.60section
Chlormethinerelated to historyThe0.60section
Chlormethinerelated to historyBis0.60section
Chlormethinerelated to historyFirst World War0.60section
Chlormethinerelated to historyIn0.60section
Chlormethinerelated to historySecond World War0.60section
Chlormethinerelated to historyAnd0.60section
Chlormethinerelated to historyAfter0.60section

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