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PDGFB: Measurement, Clinical significance & Function

Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene.

Language: English [EN]
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PDGFB topic overview

The analysis highlights Measurement, Clinical significance and Function as prominent areas in the source structure around PDGFB.

Related topics
11
Source areas
3
Connected nodes
14
Extracted relationships
157
Concept neighborhoods
10
Bridge connections
14

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 7 topics
Function · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PDG, 3MJG, 4HQU, 4HQX, 4QCI
Band
22q13.1 · 15 E1|15 37.85 cM
Bgee
olfactory bulb · apex of heart · pancreatic ductal cell · right lung · vena cava
BioGPS
More reference expression data
Chr.
Chromosome 22 (human) · Chromosome 15 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PDGFB connects Entity context

The extracted context around PDGFB shows recurring relationship patterns in the source. For example, PDGFB → activation of protein kinase activity, activation of protein kinase B activity, basolateral plasma membrane, cell chemotaxis, cell surface, cellular response to growth factor stimulus, cellular response to mycophenolic acid, chemoattractant activity, collagen binding, collagen-containing extracellular matrix, cytoplasm, development of the heart, embryonic placenta development, endoplasmic reticulum lumen, extracellular matrix, extracellular matrix organization, extracellular region, extracellular space, Golgi lumen, Golgi membrane Another extracted example is PDGFB → ankle, apex of heart, digastric muscle, left lung, left lung lobe, left ventricle, olfactory bulb, pancreatic ductal cell, right lobe of thyroid gland, right lung, right ventricle, sternocleidomastoid muscle, subcutaneous adipose tissue, temporal muscle, triceps brachii muscle, upper lobe of left lung, vastus lateralis muscle, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.

PDGFB

Top relations

Gene ontology · 92
PDGFB → activation of protein kinase activity, activation of protein kinase B activity, basolateral plasma membrane, cell chemotaxis, cell surface, cellular response to growth factor stimulus, cellular response to mycophenolic acid, chemoattractant activity, collagen binding, collagen-containing extracellular matrix, cytoplasm, development of the heart, embryonic placenta development, endoplasmic reticulum lumen, extracellular matrix, extracellular matrix organization, extracellular region, extracellular space, Golgi lumen, Golgi membrane
Bgee · 18
PDGFB → ankle, apex of heart, digastric muscle, left lung, left lung lobe, left ventricle, olfactory bulb, pancreatic ductal cell, right lobe of thyroid gland, right lung, right ventricle, sternocleidomastoid muscle, subcutaneous adipose tissue, temporal muscle, triceps brachii muscle, upper lobe of left lung, vastus lateralis muscle, vena cava
RNA expression pattern · 18
PDGFB → ankle, apex of heart, digastric muscle, left lung, left lung lobe, left ventricle, olfactory bulb, pancreatic ductal cell, right lobe of thyroid gland, right lung, right ventricle, sternocleidomastoid muscle, subcutaneous adipose tissue, temporal muscle, triceps brachii muscle, upper lobe of left lung, vastus lateralis muscle, vena cava
related to Clinical significance · 6
PDGFB → COL1A-PDGFB, COL1A1, Mutations, Reciprocal, This, Two
Band · 2
PDGFB → 15 E1|15 37.85 cM, 22q13.1
Chr. · 2
PDGFB → Chromosome 15 (mouse), Chromosome 22 (human)
End · 2
PDGFB → 39,244,982 bp, 80,014,977 bp
Aliases · 1
PDGFB → PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B
Available structures · 1
PDGFB → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PDG, 3MJG, 4HQU, 4HQX, 4QCI
BioGPS · 1
PDGFB → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp growth factor chr human band chromosome 22 platelet-derived protein location mouse subunit function encoded platelet search 244 982

PDGFB relationships Subject–Predicate–Object triples

TTTA extracted 157 structured relationships around PDGFB. Examples in this analysis include PDGFB → Aliases → PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B and PDGFB → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PDG, 3MJG, 4HQU, 4HQX, 4QCI. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PDGFBAliasesPDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B1.00infobox
PDGFBAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PDG, 3MJG, 4HQU, 4HQX, 4QCI1.00infobox
PDGFBBand22q13.11.00infobox
PDGFBBand15 E1|15 37.85 cM1.00infobox
PDGFBBgeeolfactory bulb1.00infobox
PDGFBBgeeapex of heart1.00infobox
PDGFBBgeepancreatic ductal cell1.00infobox
PDGFBBgeeright lung1.00infobox
PDGFBBgeevena cava1.00infobox
PDGFBBgeesubcutaneous adipose tissue1.00infobox
PDGFBBgeetriceps brachii muscle1.00infobox
PDGFBBgeeleft ventricle1.00infobox
PDGFBBgeeupper lobe of left lung1.00infobox
PDGFBBgeeright lobe of thyroid gland1.00infobox
PDGFBBgeeleft lung1.00infobox
PDGFBBgeedigastric muscle1.00infobox
PDGFBBgeeleft lung lobe1.00infobox
PDGFBBgeevastus lateralis muscle1.00infobox
PDGFBBgeesternocleidomastoid muscle1.00infobox
PDGFBBgeeankle1.00infobox
PDGFBBgeetemporal muscle1.00infobox
PDGFBBgeeright ventricle1.00infobox
PDGFBBioGPSMore reference expression data1.00infobox
PDGFBChr.Chromosome 22 (human)1.00infobox
PDGFBChr.Chromosome 15 (mouse)1.00infobox
PDGFBDatabasesNCBI: entry; OMA: entry1.00infobox
PDGFBEnd39,244,982 bp1.00infobox
PDGFBEnd80,014,977 bp1.00infobox
PDGFBEnsemblENSG000001003111.00infobox
PDGFBEntrez51551.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PDGFB bring nearby vocabulary together. In this analysis, examples include Gene, Chromosome and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PDGFB
    • Gene
    • Chromosome
    • Cell
    • Development
    • Function
    • Fusion
    • Platelet
    • Protein
    • Search
    • Subunit
    • Two
    • Location
  • pdgfb
    • Gene
    • Chromosome
    • Cell
    • Development
    • Function
    • Fusion
    • Platelet
    • Protein
    • Search
    • Subunit
    • Two
    • Location
  • gene
    • Pdgfb
    • Chromosome
    • Growth
    • Location
    • Human
    • Platelet-derived
    • Bp
    • Chr
    • Alpha
    • Associated
    • Cell
    • Development
  • platelet-derived growth factor
    • Factor
    • Growth
    • Platelet-derived
    • Alpha
    • Encoded
    • Protein
    • Function
    • Gene
    • Platelet
    • Search
    • Subunit
    • Pdgfb
  • ring chromosome
    • Human
    • Bp
    • Location
    • Band
    • E1
    • End
    • Function
    • Gene
    • Mouse
    • Platelet
    • Search
    • Pdgfb
  • fusion gene
    • Pdgfb
    • Chromosome
    • Growth
    • Location
    • Two
    • Human
    • Platelet-derived
    • Bp
    • Chr
    • Alpha
    • Associated
    • Cell
  • function
    • Platelet
    • Search
    • Location
    • Human
    • Significance
    • Bp
    • Chr
    • Chromosome
    • Growth
    • Alpha
    • Associated
    • Cell
  • giant cell fibroblastoma
    • Development
    • Alpha
    • Associated
    • E1
    • Encoded
    • End
    • Family
    • Function
    • Fusion
    • Mesenchymal
    • Mouse
    • Pdgfb

Connections between topic areas Semantic bridges

For PDGFB, one of the stronger structural bridges in this analysis connects PDGFB with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PDGFBClinical significance · splits 7 ⟂ 8
PDGFBOverview · splits 12 ⟂ 3
PDGFBFunction · splits 12 ⟂ 3

Map overview Semantic statistics

PDGFB

Nodes15
Edges14
Triples157
Avg. degree1.87
Density0.133333
Components1

Source & methodology

TTTA analyzes the structure around PDGFB to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PDGFB · EN edition · Analysis: TopicsToTalkAbout

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