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Nicotinamide phosphoribosyltransferase: Extracellular NAMPT, Expression and regulation & As a drug target

Nicotinamide phosphoribosyltransferase (NAmPRTase or NAMPT), formerly known as pre-B-cell colony-enhancing factor 1 (PBEF1) or visfatin for its extracellular form (eNAMPT), is an enzyme that in humans is encoded by the NAMPT gene. The intracellular form of this protein (iNAMPT) is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD+)…

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Nicotinamide phosphoribosyltransferase topic overview

The analysis highlights Extracellular NAMPT, Expression and regulation and As a drug target as prominent areas in the source structure around Nicotinamide phosphoribosyltransferase.

Related topics: 57
Source areas: 6
Connected nodes: 63
Extracted relationships: 134
Concept neighborhoods: 20
Bridge connections: 63

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Extracellular NAMPT · 14 topics

Overview · 12 topics

As a drug target · 9 topics

Expression and regulation · 9 topics

Function · 7 topics

Ligands · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.4.2.12: ↗
Aliases: NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN, nicotinamide phosphoribosyltransferase
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E5B, 2E5C, 2E5D, 2GVG, 2GVJ, 3DGR, 3DHD, 3DHF, 3DKJ, 3DKL, 4JNM, 4JR5, 4KFN, 4KFO, 4KFP, 4L4L, 4L4M, 4LTS,…
Band: 7q22.3 · 12|12 A3
Bgee: blood · pericardium · gastric mucosa · right lung · vena cava
BioGPS: More reference expression data

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Sirtuins Sirtuin
PARPs Poly ADP ribose polymerase
CD38
De novo synthesis
Tryptophan
PPi Pyrophosphate
Glycosyltransferase

Expression and regulation

SIRT1 Sirtuin 1
Endurance-trained Endurance training
Expression Gene expression
Type 2 diabetic Type 2 diabetes
Aerobic Aerobic exercise
Resistance Strength training
Proinflammatory
Macrophages Macrophage
Astrocytes Astrocyte

Extracellular NAMPT

Adipocytes Adipocyte
Adipose tissue
Cytokine
Dimer Dimer (chemistry)
Monomer
B cell
Interleukin-7
Stem cell factor
Pancreatic Pancreas
Beta cells Beta cell
Neurons Neuron
Insulin
Osaka University Medical School Osaka University Medical School?action=edit&redlink=1
Committee for Research Integrity Committee for Research Integrity?action=edit&redlink=1

As a drug target

Ligands

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Nicotinamide phosphoribosyltransferase connects Entity context

The extracted context around Nicotinamide phosphoribosyltransferase shows recurring relationship patterns in the source. For example, Nicotinamide phosphoribosyltransferase → adipose tissue development, ageing, catalytic activity, cell junction, cell-cell signaling, cellular response to amyloid-beta, cellular response to ionizing radiation, cellular response to oxygen-glucose deprivation, circadian regulation of gene expression, circadian rhythm, cytokine activity, cytoplasm, cytosol, extracellular exosome, extracellular region, extracellular space, female pregnancy, glycosyltransferase activity, identical protein binding, insulin receptor signaling pathway Another extracted example is Nicotinamide phosphoribosyltransferase → blood, decidua, digastric muscle, gallbladder, gastric mucosa, gastrula, interventricular septum, iris, left uterine tube, lower lobe of lung, myocardium of ventricle, pericardium, right lung, sternocleidomastoid muscle, tail of epididymis, temporal muscle, triceps brachii muscle, upper lobe of left lung, vastus lateralis muscle, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.

Nicotinamide phosphoribosyltransferase

Top relations

Gene ontology · 45

Nicotinamide phosphoribosyltransferase → adipose tissue development, ageing, catalytic activity, cell junction, cell-cell signaling, cellular response to amyloid-beta, cellular response to ionizing radiation, cellular response to oxygen-glucose deprivation, circadian regulation of gene expression, circadian rhythm, cytokine activity, cytoplasm, cytosol, extracellular exosome, extracellular region, extracellular space, female pregnancy, glycosyltransferase activity, identical protein binding, insulin receptor signaling pathway

Bgee · 20

Nicotinamide phosphoribosyltransferase → blood, decidua, digastric muscle, gallbladder, gastric mucosa, gastrula, interventricular septum, iris, left uterine tube, lower lobe of lung, myocardium of ventricle, pericardium, right lung, sternocleidomastoid muscle, tail of epididymis, temporal muscle, triceps brachii muscle, upper lobe of left lung, vastus lateralis muscle, vena cava

RNA expression pattern · 20

related to External links · 13

Nicotinamide phosphoribosyltransferase → Human Nicotinamide, Medicine Medical Subject Headings, MeSH, Mouse Nicotinamide, NAMPT, National Library, Overview, P43490, PDB, PDBe-KB, Q99KQ4, UCSC Genome Browser, UniProt

related to Function · 11

Nicotinamide phosphoribosyltransferase → CD38, De, NAD, NAM, Nicotinamide, NMN, PARPs, PPi, The, This, Thus

Band · 2

Nicotinamide phosphoribosyltransferase → 12|12 A3, 7q22.3

Chr. · 2

Nicotinamide phosphoribosyltransferase → Chromosome 12 (mouse), Chromosome 7 (human)

End · 2

Nicotinamide phosphoribosyltransferase → 106,285,966 bp, 32,903,348 bp

2.4.2.12 · 1

Nicotinamide phosphoribosyltransferase → ↗

Aliases · 1

Nicotinamide phosphoribosyltransferase → NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN, nicotinamide phosphoribosyltransferase

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nampt inampt nicotinamide nad enampt visfatin enzyme gene pbef human phosphoribosyltransferase bp activity cytokine chr band mouse extracellular reported nmn

Nicotinamide phosphoribosyltransferase relationships Subject–Predicate–Object triples

TTTA extracted 134 structured relationships around Nicotinamide phosphoribosyltransferase. Examples in this analysis include Nicotinamide phosphoribosyltransferase → 2.4.2.12 → ↗ and Nicotinamide phosphoribosyltransferase → Aliases → NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN, nicotinamide phosphoribosyltransferase. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Nicotinamide phosphoribosyltransferase	2.4.2.12	↗	1.00	infobox
Nicotinamide phosphoribosyltransferase	Aliases	NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN, nicotinamide phosphoribosyltransferase	1.00	infobox
Nicotinamide phosphoribosyltransferase	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E5B, 2E5C, 2E5D, 2GVG, 2GVJ, 3DGR, 3DHD, 3DHF, 3DKJ, 3DKL, 4JNM, 4JR5, 4KFN, 4KFO, 4KFP, 4L4L, 4L4M, 4LTS,…	1.00	infobox
Nicotinamide phosphoribosyltransferase	Band	7q22.3	1.00	infobox
Nicotinamide phosphoribosyltransferase	Band	12\|12 A3	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	blood	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	pericardium	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	gastric mucosa	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	right lung	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	vena cava	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	upper lobe of left lung	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	left uterine tube	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	tail of epididymis	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	lower lobe of lung	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	gallbladder	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	gastrula	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	decidua	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	temporal muscle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	triceps brachii muscle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	iris	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	sternocleidomastoid muscle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	digastric muscle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	vastus lateralis muscle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	myocardium of ventricle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	interventricular septum	1.00	infobox
Nicotinamide phosphoribosyltransferase	BioGPS	More reference expression data	1.00	infobox
Nicotinamide phosphoribosyltransferase	Chr.	Chromosome 7 (human)	1.00	infobox
Nicotinamide phosphoribosyltransferase	Chr.	Chromosome 12 (mouse)	1.00	infobox
Nicotinamide phosphoribosyltransferase	Databases	NCBI: entry; OMA: entry	1.00	infobox
Nicotinamide phosphoribosyltransferase	End	106,285,966 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Nicotinamide phosphoribosyltransferase bring nearby vocabulary together. In this analysis, examples include Phosphoribosyltransferase, Nmn and Pdb. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Nicotinamide phosphoribosyltransferase
- Phosphoribosyltransferase
- Nmn
- Pdb
- Uniprot
- Extracellular
- Gene
- Human
- Expression
- Form
- Function
- Pathway
- Salvage
nicotinamide phosphoribosyltransferase
- Phosphoribosyltransferase
- Pdb
- Uniprot
- Nmn
- Extracellular
- Gene
- Expression
- Function
- Human
- Chromosome
- Location
- Protein
extracellular
- Expression
- Function
- Phosphoribosyltransferase
- Cell
- Chromosome
- Location
- Nampt
- Gene
- Nicotinamide
- Bp
- Chr
- Enzyme
enzyme
- Pbef
- Intracellular
- Extracellular
- Nampt
- Visfatin
- Phosphoribosyltransferase
- Gene
- Nicotinamide
- Form
- Tlr4
- Cell
- Inampt
gene
- Location
- Human
- Mouse
- Nampt
- Phosphoribosyltransferase
- Chromosome
- Nicotinamide
- Bp
- Chr
- Pbef
- Activity
- Expression
nicotinamide adenine dinucleotide
- Phosphoribosyltransferase
- Nmn
- Pdb
- Uniprot
- Extracellular
- Gene
- Human
- Expression
- Form
- Function
- Pathway
- Salvage
nicotinamide
- Phosphoribosyltransferase
- Nmn
- Pdb
- Uniprot
- Extracellular
- Gene
- Human
- Expression
- Form
- Function
- Pathway
- Salvage
nicotinamide mononucleotide
- Phosphoribosyltransferase
- Nmn
- Pdb
- Uniprot
- Extracellular
- Gene
- Human
- Expression
- Form
- Function
- Pathway
- Salvage

Connections between topic areas Semantic bridges

For Nicotinamide phosphoribosyltransferase, one of the stronger structural bridges in this analysis connects Nicotinamide phosphoribosyltransferase with Extracellular NAMPT. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Nicotinamide phosphoribosyltransferase — Extracellular NAMPT · splits 49 ⟂ 15

Nicotinamide phosphoribosyltransferase — Overview · splits 51 ⟂ 13

Nicotinamide phosphoribosyltransferase — Expression and regulation · splits 54 ⟂ 10

Nicotinamide phosphoribosyltransferase — As a drug target · splits 54 ⟂ 10

Nicotinamide phosphoribosyltransferase — Function · splits 56 ⟂ 8

Nicotinamide phosphoribosyltransferase — Ligands · splits 57 ⟂ 7

Map overview Semantic statistics

Nicotinamide phosphoribosyltransferase

Nodes64

Edges63

Triples134

Avg. degree1.97

Density0.03125

Components1

Source & methodology

TTTA analyzes the structure around Nicotinamide phosphoribosyltransferase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Extracellular NAMPT, Expression and regulation & As a drug target, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Nicotinamide phosphoribosyltransferase · EN edition · Analysis: TopicsToTalkAbout

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