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Melatonin as a medication and supplement

Melatonin is a naturally occurring hormone produced in the brain that is also used as a dietary supplement and medication. As a hormone, melatonin is released by the pineal gland and is involved in sleep–wake cycles. As a supplement and medication, it is often used for the short-term treatment of disrupted sleep patterns such as from jet lag or shift…

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3D model (JSmol)
Interactive image
Addiction liability
None
AHFS/Drugs.com
Consumer Drug Information · MedFacts Natural Products
ATC code
N05CH01 (WHO)
Bioavailability
~15% (range 2.5–50%)
CAS Number
73-31-4 Y

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Overview

Medical uses

Contraindications

Adverse effects

Overdose

Interactions

Pharmacology

Chemistry

Research

History

Society and culture

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Map overview Semantic statistics

Melatonin as a medication and supplement

Nodes168
Edges167
Triples45
Avg. degree1.99
Density0.011905
Components1

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Melatonin as a medication and supplement

Top relations

Legal status · 6
Melatonin as a medication and supplement → AU: S4 (Prescription only), CA: OTC / Rx-only, EU: Rx, OTC, In general: ℞ (Prescription only), UK: POM (Prescription only), US: OTC
AHFS/Drugs.com · 2
Melatonin as a medication and supplement → Consumer Drug Information, MedFacts Natural Products
3D model (JSmol) · 1
Melatonin as a medication and supplement → Interactive image
Addiction liability · 1
Melatonin as a medication and supplement → None
ATC code · 1
Melatonin as a medication and supplement → N05CH01 (WHO)
Bioavailability · 1
Melatonin as a medication and supplement → ~15% (range 2.5–50%)
CAS Number · 1
Melatonin as a medication and supplement → 73-31-4 Y
ChEBI · 1
Melatonin as a medication and supplement → CHEBI:16796 Y
ChEMBL · 1
Melatonin as a medication and supplement → ChEMBL45 Y
ChemSpider · 1
Melatonin as a medication and supplement → 872 Y

Important terminology Word statistics

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Important terminology

melatonin sleep found people may treatment use used medication insomnia doses also prolonged-release effects evidence levels disorders low over-the-counter mg

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Melatonin as a medication and supplement3D model (JSmol)Interactive image1.00infobox
Melatonin as a medication and supplementAddiction liabilityNone1.00infobox
Melatonin as a medication and supplementAHFS/Drugs.comConsumer Drug Information1.00infobox
Melatonin as a medication and supplementAHFS/Drugs.comMedFacts Natural Products1.00infobox
Melatonin as a medication and supplementATC codeN05CH01 (WHO)1.00infobox
Melatonin as a medication and supplementBioavailability~15% (range 2.5–50%)1.00infobox
Melatonin as a medication and supplementCAS Number73-31-4 Y1.00infobox
Melatonin as a medication and supplementChEBICHEBI:16796 Y1.00infobox
Melatonin as a medication and supplementChEMBLChEMBL45 Y1.00infobox
Melatonin as a medication and supplementChemSpider872 Y1.00infobox
Melatonin as a medication and supplementDependence liabilityPhysical: Low Psychological: None1.00infobox
Melatonin as a medication and supplementDrug classMelatonin receptor agonist1.00infobox
Melatonin as a medication and supplementDrugBankDB01065 Y1.00infobox
Melatonin as a medication and supplementDuration of actionA few hours1.00infobox
Melatonin as a medication and supplementElimination half-lifeIR: 20–60 minutes PR: 3.5–4 hours1.00infobox
Melatonin as a medication and supplementExcretionKidney1.00infobox
Melatonin as a medication and supplementFormulaC13H16N2O21.00infobox
Melatonin as a medication and supplementIUPHAR/BPS2241.00infobox
Melatonin as a medication and supplementKEGGD08170 Y1.00infobox
Melatonin as a medication and supplementLegal statusAU: S4 (Prescription only)1.00infobox
Melatonin as a medication and supplementLegal statusCA: OTC / Rx-only1.00infobox
Melatonin as a medication and supplementLegal statusUK: POM (Prescription only)1.00infobox
Melatonin as a medication and supplementLegal statusUS: OTC1.00infobox
Melatonin as a medication and supplementLegal statusEU: Rx, OTC1.00infobox
Melatonin as a medication and supplementLegal statusIn general: ℞ (Prescription only)1.00infobox
Melatonin as a medication and supplementLicense dataUS DailyMed: Melatonin1.00infobox
Melatonin as a medication and supplementMelting point117 °C (243 °F)1.00infobox
Melatonin as a medication and supplementMetabolismLiver via CYP1A2 mediated 6-hydroxylation1.00infobox
Melatonin as a medication and supplementMetabolites6-Hydroxymelatonin, N-acetyl-5-hydroxytryptamine, 5-methoxytryptamine1.00infobox
Melatonin as a medication and supplementMolar mass232.283 g·mol−11.00infobox

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