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Lymphocyte-activation gene 3: History & Applications

Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biological effects on T cell function…

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Lymphocyte-activation gene 3 topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Lymphocyte-activation gene 3.

Related topics
65
Source areas
7
Connected nodes
72
Extracted relationships
67
Related term clusters
23
Bridge connections
72

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

History · 29 topics
Function · 9 topics
Overview · 9 topics
Use as a pharmaceutical and as a drug target · 7 topics
Gene · 4 topics
Tissue distribution · 4 topics
Protein · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
LAG3, CD223, lymphocyte activating 3
Band
12p13.31 · 6|6 F2
Bgee
granulocyte · right ovary · left ovary · gonad · spleen
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)
Databases
NCBI: entry; OMA: entry

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Lymphocyte-activation gene 3
6Protein · Gene · Cluster of differentiation
4T cell activation · Natural killer cells · B cells
4Exon · Intron · CD4
4MHC class II · CTLA-4 · Programmed cell death 1

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Protein

Tissue distribution

Function

Use as a pharmaceutical and as a drug target

History

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Lymphocyte-activation gene 3 connects Entity context

The extracted context around Lymphocyte-activation gene 3 shows recurring relationship patterns in the source. For example, Lymphocyte-activation gene 3 → body of uterus, embryo, epiblast, gonad, granulocyte, left ovary, left uterine tube, lip, lymph node, primary visual cortex, right lobe of liver, right ovary, spleen, superior frontal gyrus, testicle, thymus, ventricular zone, zygote Another extracted example is Lymphocyte-activation gene 3 → antigen binding, antigen processing and presentation of exogenous peptide antigen via MHC class II, cell surface receptor signaling pathway, external side of plasma membrane, integral component of membrane, membrane, MHC class II protein binding, negative regulation of T cell activation, plasma membrane, positive regulation of natural killer cell mediated cytotoxicity, transmembrane signaling receptor activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

Lymphocyte-activation gene 3

Top relations

Bgee · 18
Lymphocyte-activation gene 3 → body of uterus, embryo, epiblast, gonad, granulocyte, left ovary, left uterine tube, lip, lymph node, primary visual cortex, right lobe of liver, right ovary, spleen, superior frontal gyrus, testicle, thymus, ventricular zone, zygote
RNA expression pattern · 18
Lymphocyte-activation gene 3 → body of uterus, embryo, epiblast, gonad, granulocyte, left ovary, left uterine tube, lip, lymph node, primary visual cortex, right lobe of liver, right ovary, spleen, superior frontal gyrus, testicle, thymus, ventricular zone, zygote
Gene ontology · 11
Lymphocyte-activation gene 3 → antigen binding, antigen processing and presentation of exogenous peptide antigen via MHC class II, cell surface receptor signaling pathway, external side of plasma membrane, integral component of membrane, membrane, MHC class II protein binding, negative regulation of T cell activation, plasma membrane, positive regulation of natural killer cell mediated cytotoxicity, transmembrane signaling receptor activity
Band · 2
Lymphocyte-activation gene 3 → 12p13.31, 6|6 F2
Chr. · 2
Lymphocyte-activation gene 3 → Chromosome 12 (human), Chromosome 6 (mouse)
End · 2
Lymphocyte-activation gene 3 → 124,888,668 bp, 6,778,455 bp
Aliases · 1
Lymphocyte-activation gene 3 → LAG3, CD223, lymphocyte activating 3
BioGPS · 1
Lymphocyte-activation gene 3 → More reference expression data
Databases · 1
Lymphocyte-activation gene 3 → NCBI: entry; OMA: entry
Ensembl · 1
Lymphocyte-activation gene 3 → ENSG00000089692

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

lag3 lag-3 cells human also cd4 cell protein shown gene cd8 function immune mhc class ii found reported antibodies demonstrated

Lymphocyte-activation gene 3 relationships Subject–Predicate–Object triples

TTTA extracted 67 structured relationships around Lymphocyte-activation gene 3. Examples in this analysis include Lymphocyte-activation gene 3 → Aliases → LAG3, CD223, lymphocyte activating 3 and Lymphocyte-activation gene 3 → Band → 12p13.31. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Lymphocyte-activation gene 3AliasesLAG3, CD223, lymphocyte activating 31.00infobox
Lymphocyte-activation gene 3Band12p13.311.00infobox
Lymphocyte-activation gene 3Band6|6 F21.00infobox
Lymphocyte-activation gene 3Bgeegranulocyte1.00infobox
Lymphocyte-activation gene 3Bgeeright ovary1.00infobox
Lymphocyte-activation gene 3Bgeeleft ovary1.00infobox
Lymphocyte-activation gene 3Bgeegonad1.00infobox
Lymphocyte-activation gene 3Bgeespleen1.00infobox
Lymphocyte-activation gene 3Bgeetesticle1.00infobox
Lymphocyte-activation gene 3Bgeeright lobe of liver1.00infobox
Lymphocyte-activation gene 3Bgeebody of uterus1.00infobox
Lymphocyte-activation gene 3Bgeeleft uterine tube1.00infobox
Lymphocyte-activation gene 3Bgeelymph node1.00infobox
Lymphocyte-activation gene 3Bgeeembryo1.00infobox
Lymphocyte-activation gene 3Bgeethymus1.00infobox
Lymphocyte-activation gene 3Bgeezygote1.00infobox
Lymphocyte-activation gene 3Bgeelip1.00infobox
Lymphocyte-activation gene 3Bgeesuperior frontal gyrus1.00infobox
Lymphocyte-activation gene 3Bgeeepiblast1.00infobox
Lymphocyte-activation gene 3Bgeeprimary visual cortex1.00infobox
Lymphocyte-activation gene 3Bgeeventricular zone1.00infobox
Lymphocyte-activation gene 3BioGPSMore reference expression data1.00infobox
Lymphocyte-activation gene 3Chr.Chromosome 12 (human)1.00infobox
Lymphocyte-activation gene 3Chr.Chromosome 6 (mouse)1.00infobox
Lymphocyte-activation gene 3DatabasesNCBI: entry; OMA: entry1.00infobox
Lymphocyte-activation gene 3End6,778,455 bp1.00infobox
Lymphocyte-activation gene 3End124,888,668 bp1.00infobox
Lymphocyte-activation gene 3EnsemblENSG000000896921.00infobox
Lymphocyte-activation gene 3Entrez39021.00infobox
Lymphocyte-activation gene 3External IDsOMIM: 153337; MGI: 106588; GeneCards: LAG31.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Lymphocyte-activation gene 3 bring nearby vocabulary together. In this analysis, examples include Chromosome, Bp and Chr. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • t cell
    • Surface
    • Shown
    • Activation
    • Lag-3
    • Function
    • Demonstrated
    • Lag3
    • Cancer
    • Could
    • Class
    • Ii
    • Mhc
  • mhc class ii
    • Ii
    • Mhc
    • Binding
    • Activation
    • Reported
    • Human
    • Protein
    • Lag-3
    • Band
    • Bp
    • Chr
    • Chromosome
  • function
    • Binding
    • Protein
    • Surface
    • Activation
    • Pd-1
    • Gene
    • Immune
    • Human
    • Drug
    • Treg
    • Band
    • Bp
  • activated t cells
    • Dendritic
    • Shown
    • Lag-3
    • Lag3
    • Role
    • Expression
    • Antibodies
    • Treg
    • Pd-1
    • Demonstrated
    • Reported
    • Human
  • natural killer cells
    • Dendritic
    • Shown
    • Lag-3
    • Lag3
    • Role
    • Expression
    • Antibodies
    • Treg
    • Pd-1
    • Demonstrated
    • Reported
    • Human
  • b cells
    • Dendritic
    • Shown
    • Lag-3
    • Lag3
    • Role
    • Expression
    • Antibodies
    • Treg
    • Pd-1
    • Demonstrated
    • Reported
    • Human
  • plasmacytoid dendritic cells
    • Dendritic
    • Shown
    • Lag-3
    • Lag3
    • Role
    • Expression
    • Antibodies
    • Treg
    • Pd-1
    • Demonstrated
    • Reported
    • Human
  • dendritic cells
    • Dendritic
    • Shown
    • Lag-3
    • Lag3
    • Role
    • Expression
    • Antibodies
    • Treg
    • Pd-1
    • Demonstrated
    • Reported
    • Human

Connections between topic areas Semantic bridges

For Lymphocyte-activation gene 3, one of the stronger structural bridges in this analysis connects Lymphocyte-activation gene 3 with History. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Lymphocyte-activation gene 3 — History · splits 43 ⟂ 30
Lymphocyte-activation gene 3 — Overview · splits 63 ⟂ 10
Lymphocyte-activation gene 3 — Function · splits 63 ⟂ 10
Lymphocyte-activation gene 3 — Use as a pharmaceutical and as a drug target · splits 65 ⟂ 8
Lymphocyte-activation gene 3 — Gene · splits 68 ⟂ 5
Lymphocyte-activation gene 3 — Tissue distribution · splits 68 ⟂ 5
Lymphocyte-activation gene 3 — Protein · splits 69 ⟂ 4

Map overview Semantic statistics

Lymphocyte-activation gene 3

Nodes73
Edges72
Triples67
Avg. degree1.97
Density0.027397
Components1

Source & methodology

TTTA analyzes the structure around Lymphocyte-activation gene 3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Lymphocyte-activation gene 3 · EN edition · Analysis: TopicsToTalkAbout

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