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Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biological effects on T cell function…
The analysis highlights History and Applications as prominent areas in the source structure around Lymphocyte-activation gene 3.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around Lymphocyte-activation gene 3 shows recurring relationship patterns in the source. For example, Lymphocyte-activation gene 3 → body of uterus, embryo, epiblast, gonad, granulocyte, left ovary, left uterine tube, lip, lymph node, primary visual cortex, right lobe of liver, right ovary, spleen, superior frontal gyrus, testicle, thymus, ventricular zone, zygote Another extracted example is Lymphocyte-activation gene 3 → antigen binding, antigen processing and presentation of exogenous peptide antigen via MHC class II, cell surface receptor signaling pathway, external side of plasma membrane, integral component of membrane, membrane, MHC class II protein binding, negative regulation of T cell activation, plasma membrane, positive regulation of natural killer cell mediated cytotoxicity, transmembrane signaling receptor activity. Use these groups to spot repeated connection types before inspecting the individual relationships.
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lag3 lag-3 cells human also cd4 cell protein shown gene cd8 function immune mhc class ii found reported antibodies demonstrated
TTTA extracted 67 structured relationships around Lymphocyte-activation gene 3. Examples in this analysis include Lymphocyte-activation gene 3 → Aliases → LAG3, CD223, lymphocyte activating 3 and Lymphocyte-activation gene 3 → Band → 12p13.31. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Lymphocyte-activation gene 3 | Aliases | LAG3, CD223, lymphocyte activating 3 | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Band | 12p13.31 | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Band | 6|6 F2 | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | granulocyte | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | right ovary | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | left ovary | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | gonad | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | spleen | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | testicle | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | right lobe of liver | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | body of uterus | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | left uterine tube | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | lymph node | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | embryo | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | thymus | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | zygote | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | lip | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | superior frontal gyrus | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | epiblast | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | primary visual cortex | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Bgee | ventricular zone | 1.00 | infobox |
| Lymphocyte-activation gene 3 | BioGPS | More reference expression data | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Chr. | Chromosome 12 (human) | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Chr. | Chromosome 6 (mouse) | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Lymphocyte-activation gene 3 | End | 6,778,455 bp | 1.00 | infobox |
| Lymphocyte-activation gene 3 | End | 124,888,668 bp | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Ensembl | ENSG00000089692 | 1.00 | infobox |
| Lymphocyte-activation gene 3 | Entrez | 3902 | 1.00 | infobox |
| Lymphocyte-activation gene 3 | External IDs | OMIM: 153337; MGI: 106588; GeneCards: LAG3 | 1.00 | infobox |
The concept neighborhoods around Lymphocyte-activation gene 3 bring nearby vocabulary together. In this analysis, examples include Chromosome, Bp and Chr. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Lymphocyte-activation gene 3, one of the stronger structural bridges in this analysis connects Lymphocyte-activation gene 3 with History. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Lymphocyte-activation gene 3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Lymphocyte-activation gene 3 · EN edition · Analysis: TopicsToTalkAbout