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Letrozole: Applications & Research

Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women.

Language: English [EN]
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Letrozole topic overview

The analysis highlights Applications and Research as prominent areas in the source structure around Letrozole.

Related topics
47
Source areas
7
Connected nodes
54
Extracted relationships
54
Concept neighborhoods
17
Bridge connections
54

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 12 topics
Medical uses · 10 topics
Research · 7 topics
Interactions · 6 topics
Side effects · 6 topics
Overview · 5 topics
Contraindications · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L02BG04 (WHO)
Bioavailability
99.9%
CAS Number
112809-51-5 Y
ChEBI
CHEBI:6413 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Side effects

Interactions

Pharmacology

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Letrozole connects Entity context

The extracted context around Letrozole shows recurring relationship patterns in the source. For example, Letrozole → Clomid, Compared, India, Indian, It, The Another extracted example is Letrozole → CA: Schedule VII, EU: Rx-only, UK: POM (Prescription only), US: ℞-only. Use these groups to spot repeated connection types before inspecting the individual relationships.

Letrozole

Top relations

related to Ovulation induction · 6
Letrozole → Clomid, Compared, India, Indian, It, The
Legal status · 4
Letrozole → CA: Schedule VII, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Breast cancer · 3
Letrozole → Drug Administration, FDA, United States Food
related to Interactions · 3
Letrozole → CYP2A6, CYP2A7, CYP2C19
related to Pharmacodynamics · 3
Letrozole → It, P450, The
related to Contraindications · 2
Letrozole → Breast, Precautions
related to Research · 2
Letrozole → It, The
related to Use in sports · 2
Letrozole → WADA, World Antidoping Agency
3D model (JSmol) · 1
Letrozole → Interactive image
AHFS/Drugs.com · 1
Letrozole → Monograph

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

aromatase breast women also used cancer use inhibitor tamoxifen post-menopausal shown treatment medication side effects medical drug antiestrogen estrogen effective

Letrozole relationships Subject–Predicate–Object triples

TTTA extracted 54 structured relationships around Letrozole. Examples in this analysis include Letrozole → 3D model (JSmol) → Interactive image and Letrozole → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Letrozole3D model (JSmol)Interactive image1.00infobox
LetrozoleAHFS/Drugs.comMonograph1.00infobox
LetrozoleATC codeL02BG04 (WHO)1.00infobox
LetrozoleBioavailability99.9%1.00infobox
LetrozoleCAS Number112809-51-5 Y1.00infobox
LetrozoleChEBICHEBI:6413 Y1.00infobox
LetrozoleChEMBLChEMBL1444 Y1.00infobox
LetrozoleChemSpider3765 Y1.00infobox
LetrozoleCompTox Dashboard (EPA)DTXSID40232021.00infobox
LetrozoleDrug classAromatase inhibitor; Antiestrogen1.00infobox
LetrozoleDrugBankDB01006 Y1.00infobox
LetrozoleECHA InfoCard100.200.3571.00infobox
LetrozoleElimination half-life2 days1.00infobox
LetrozoleExcretionKidney1.00infobox
LetrozoleFormulaC17H11N51.00infobox
LetrozoleIUPHAR/BPS52091.00infobox
LetrozoleKEGGD00964 Y1.00infobox
LetrozoleLegal statusCA: Schedule VII1.00infobox
LetrozoleLegal statusUK: POM (Prescription only)1.00infobox
LetrozoleLegal statusUS: ℞-only1.00infobox
LetrozoleLegal statusEU: Rx-only1.00infobox
LetrozoleLicense dataUS DailyMed: Letrozole1.00infobox
LetrozoleMedlinePlusa6980041.00infobox
LetrozoleMetabolismpharmacologically-inactive metabolites Bis(4-cyanophenyl)methanol and 4,4'-dicyanobenzophenone.1.00infobox
LetrozoleMolar mass285.310 g·mol−11.00infobox
LetrozoleProtein binding60%, mainly to albumin1.00infobox
LetrozolePubChem CID39021.00infobox
LetrozoleRoutes of administrationBy mouth1.00infobox
LetrozoleTrade namesFemara, others1.00infobox
LetrozoleUNII7LKK855W8I1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Letrozole bring nearby vocabulary together. In this analysis, examples include Women, Breast and Shown. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Letrozole
    • Women
    • Breast
    • Shown
    • Cancer
    • Used
    • Drug
    • Effective
    • Post-menopausal
    • Treatment
    • Aromatase
    • Also
    • Antiestrogen
  • letrozole
    • Women
    • Breast
    • Shown
    • Cancer
    • Used
    • Drug
    • Effective
    • Post-menopausal
    • Treatment
    • Aromatase
    • Also
    • Antiestrogen
  • aromatase inhibitor
    • Inhibitor
    • Others
    • Antiestrogen
    • Femara
    • Cancer
    • Drug
    • Effects
    • Side
    • Use
    • Breast
    • Abortion
    • Drugs
  • breast cancer
    • Cancer
    • Tamoxifen
    • Receptor
    • Women
    • Treatment
    • Femara
    • Name
    • Others
    • Post-menopausal
    • Hormone
    • Status
    • Drug
  • food and drug administration
    • Status
    • Effects
    • Side
    • Drugs
    • Femara
    • Induction
    • Interactions
    • Others
    • States
    • United
    • World
    • Antiestrogen
  • performance enhancing drug
    • Status
    • Effects
    • Side
    • Drugs
    • Femara
    • Induction
    • Interactions
    • Others
    • States
    • United
    • World
    • Antiestrogen
  • aromatase
    • Inhibitor
    • Femara
    • Others
    • Antiestrogen
    • Drug
    • Effects
    • Side
    • Cancer
    • Use
    • Used
    • Breast
    • Letrozole
  • antiestrogen
    • Inhibitor
    • Aromatase
    • Drugs
    • Femara
    • Induction
    • Interactions
    • Others
    • Medical
    • Ovulation
    • Status
    • Drug
    • Effects

Connections between topic areas Semantic bridges

For Letrozole, one of the stronger structural bridges in this analysis connects Letrozole with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
LetrozolePharmacology · splits 42 ⟂ 13
LetrozoleMedical uses · splits 44 ⟂ 11
LetrozoleResearch · splits 47 ⟂ 8
LetrozoleSide effects · splits 48 ⟂ 7
LetrozoleInteractions · splits 48 ⟂ 7
LetrozoleOverview · splits 49 ⟂ 6

Map overview Semantic statistics

Letrozole

Nodes55
Edges54
Triples54
Avg. degree1.96
Density0.036364
Components1

Source & methodology

TTTA analyzes the structure around Letrozole to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Letrozole · EN edition · Analysis: TopicsToTalkAbout

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