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Clomifene

Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate, including those with polyendocrine metabolic ovarian syndrome. It is taken by mouth.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
G03GB02 (WHO)
Bioavailability
High (>90%)
CAS Number
911-45-5 Y
ChEBI
CHEBI:3752 Y

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Overview

Medical uses

Prohibited use in sports

Contraindications

Side effects

Pharmacology

Chemistry

History

Research

Advanced semantic analysis

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Map overview Semantic statistics

Clomifene

Nodes144
Edges143
Triples155
Avg. degree1.99
Density0.013889
Components1

How this topic connects Entity context

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Clomifene

Top relations

related to Brand names · 76
Clomifene → Beclom, Bemot, Biogen, Blesifen, Chloramiphene, Clofert, Clomene, ClomHEXAL, Clomi, Clomid, Clomidac, Clomifen, Clomifencitrat, Clomifeni, Clomifeno, Clomifert, Clomifène, Clomihexal, Clomiphen, Clomiphene
related to history · 16
Clomifene → Clinical, Clomid, Cosmetic Act, Drug, Federal Food, Frank Palopoli, IND, Investigational New Drug Application, It, Kefauver Harris Amendment, Merrell, Merrell Chemical Company, November, Scientists, Short-term, William
related to Pharmacokinetics · 7
Clomifene → CYP2D6, In, Individuals, N-desethylclomiphene, N-desethylclomiphenewas, N-oxide, Primarily
related to Prohibited use in sports · 6
Clomifene → Because, It, Like, S4, The World Anti-Doping Agency, WADA
related to Cancer risk · 4
Clomifene → Some, Subsequent, This, Thyroid
related to Chemistry · 4
Clomifene → It, The, The United States Pharmacopeia, These
Legal status · 3
Clomifene → AU: S4 (Prescription only), UK: POM (Prescription only), US: ℞-only
is a · 3
Clomifene → long-acting ER ligand, prodrug being activated via similar metabolic pathways as the related triphenylethylene SERMs tamoxifen and toremifene, prodrug most importantly of 4-hydroxyclomifene and 4-hydroxy-N-desethylclomiphene
related to Reproductive medicine · 3
Clomifene → Evidence, In, The
has effect · 2
Clomifene → Less, The

Important terminology Word statistics

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Important terminology

testosterone levels use cancer effects treatment found used estrogen liver enclomifene zuclomifene 4-hydroxyclomifene ovarian days receptor increase men include ovulation

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Clomifene3D model (JSmol)Interactive image1.00infobox
ClomifeneAHFS/Drugs.comMonograph1.00infobox
ClomifeneATC codeG03GB02 (WHO)1.00infobox
ClomifeneBioavailabilityHigh (>90%)1.00infobox
ClomifeneCAS Number911-45-5 Y1.00infobox
ClomifeneChEBICHEBI:3752 Y1.00infobox
ClomifeneChEMBLChEMBL2355051 Y1.00infobox
ClomifeneChemSpider2698 Y1.00infobox
ClomifeneCompTox Dashboard (EPA)DTXSID10228431.00infobox
ClomifeneDrug classSelective estrogen receptor modulator; Progonadotropin1.00infobox
ClomifeneDrugBankDB00882 Y1.00infobox
ClomifeneECHA InfoCard100.011.8261.00infobox
ClomifeneElimination half-life4–7 days active metabolites: 4-OH-CLO : 13–34 hrs 4-OH-DE-CLO : 15–37 hrs1.00infobox
ClomifeneExcretionMainly feces, some in urine1.00infobox
ClomifeneFormulaC26H28ClNO1.00infobox
ClomifeneIUPHAR/BPS41591.00infobox
ClomifeneKEGGD07726 Y1.00infobox
ClomifeneLegal statusAU: S4 (Prescription only)1.00infobox
ClomifeneLegal statusUK: POM (Prescription only)1.00infobox
ClomifeneLegal statusUS: ℞-only1.00infobox
ClomifeneLicense dataUS DailyMed: Clomiphene1.00infobox
ClomifeneMedlinePlusa6827041.00infobox
ClomifeneMetabolismLiver CYP2D6 (with enterohepatic circulation)1.00infobox
ClomifeneMetabolites4-Hydroxyclomiphene (4-OH-CLO), 4-Hydroxy-N-desethylclomiphene (4-OH-DE-CLO)1.00infobox
ClomifeneMolar mass405.97 g·mol−11.00infobox
ClomifeneOther namesClomiphene; Chloramifene; Chloramiphene; MRL-41; MRL/41; NSC-357701.00infobox
ClomifenePregnancy categoryAU: B31.00infobox
ClomifenePubChem CID28001.00infobox
ClomifeneRoutes of administrationBy mouth1.00infobox
ClomifeneTrade namesClomid, Serophene, others1.00infobox

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