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Mefloquine

Mefloquine, sold under the brand name Lariam among others, is a medication used to prevent or treat malaria. When used for prevention it is typically started before potential exposure and continued for several weeks after potential exposure. It can be used to treat mild or moderate malaria but is not recommended for severe malaria. It is taken by mouth.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
P01BC02 (WHO)
CAS Number
53230-10-7 Y
ChEMBL
ChEMBL416956 N
ChemSpider
37171 Y

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Overview

Medical uses

Contraindications

Adverse effects

Pharmacology

Chemistry

History

Research

In popular culture

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Map overview Semantic statistics

Mefloquine

Nodes119
Edges118
Triples132
Avg. degree1.98
Density0.016807
Components1

How this topic connects Entity context

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Mefloquine

Top relations

related to history · 14
Mefloquine → Defense, FDA, Hoffman-LaRoche, II, III, Most, PPV, Public-Private Venture, Research, Smith Kline, US Department, Vietnam, Walter Reed Army Institute, WRAIR
related to Military · 10
Mefloquine → Afghanistan, Australian, Between, Canadian, December, German, Green Berets, In, UK, US Army
related to Chemistry · 9
Mefloquine → Essentially, Hoffmann-La Roche, However, Mefloquine's, N-tetramethylenetryptamine, Plasma, Specifically, Swiss, The
related to External links · 9
Mefloquine → Archived, Blogger, Drug Information Portal, Hallucinogens You Probably Haven't, Heard, June, Medicine, National Library, Nervewing
has prevention · 8
Mefloquine → America, Disease Control, Doxycycline, If, Infectious Disease Society, It, Prevention, United States Centers
related to Neurologic and psychiatric · 8
Mefloquine → Central, Drug Administration, FDA, In, Neurologic, Psychiatric, US Food, When
has treatment · 5
Mefloquine → Disease Control, It, Plasmodium, Prevention, United States' Centers
related to Pregnancy and breastfeeding · 5
Mefloquine → Available, Compared, In, The World Health Organization, WHO
related to Resistance to mefloquine · 5
Mefloquine → Cambodia, Pfmdr1, Resistance, Southeast Asia, The
Legal status · 4
Mefloquine → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only

Important terminology Word statistics

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Important terminology

effects drug malaria side use recommended used health liver include may hallucinations seizures pregnancy one resistance treatment psychiatric prevention lariam

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Mefloquine3D model (JSmol)Interactive image1.00infobox
MefloquineAHFS/Drugs.comMonograph1.00infobox
MefloquineATC codeP01BC02 (WHO)1.00infobox
MefloquineCAS Number53230-10-7 Y1.00infobox
MefloquineChEMBLChEMBL416956 N1.00infobox
MefloquineChemSpider37171 Y1.00infobox
MefloquineChiralityRacemic mixture1.00infobox
MefloquineCompTox Dashboard (EPA)DTXSID508606361.00infobox
MefloquineDrug classAntimalarial1.00infobox
MefloquineDrugBankDB00358 Y1.00infobox
MefloquineElimination half-life2 to 4 weeks1.00infobox
MefloquineExcretionPrimarily bile and feces; urine (9% as unchanged drug, 4% as primary metabolite)1.00infobox
MefloquineFormulaC17H16F6N2O1.00infobox
MefloquineKEGGD04895 Y1.00infobox
MefloquineLegal statusAU: S4 (Prescription only)1.00infobox
MefloquineLegal statusCA: ℞-only1.00infobox
MefloquineLegal statusUK: POM (Prescription only)1.00infobox
MefloquineLegal statusUS: ℞-only1.00infobox
MefloquineLicense dataUS DailyMed: Mefloquine1.00infobox
MefloquineMedlinePlusa6030301.00infobox
MefloquineMetabolismExtensive liver; main metabolite is inactive1.00infobox
MefloquineMolar mass378.318 g·mol−11.00infobox
MefloquineNIAID ChemDB0052181.00infobox
MefloquineOther names2,8-Trifluoromethyl-β-hydroxy-α,N-tetramethylene-quinolinylethylamine1.00infobox
MefloquinePregnancy categoryAU: B31.00infobox
MefloquinePubChem CID406921.00infobox
MefloquineRoutes of administrationOral1.00infobox
MefloquineTrade namesLariam, Mephaquin, Mefliam, others1.00infobox
MefloquineUNIITML814419R1.00infobox
Mefloquineis aquinolinylethylamine0.90text

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